Stem Cell and Liver Regeneration

by Okita, Kiwamu

• ISBN13: 9784431401995
• ISBN10: 4431401997
• Format: Hardcover
• Copyright: 2004-01-01
• Publisher: Springer Verlag

Summary

Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significantly to the treatment of liver diseases. The existence of the liver stem cell had long been debated, but it is now generally accepted that the liver contains cells with stem-like properties and that these cells can be activated to proliferate and differentiate into mature hepatocytes under certain conditions. There is also a substantial body of evidence to suggest that oval cells are involved in liver regeneration as they differentiate into hepatocytes and biliary cells. This book is a collection of work on stem cell and liver regeneration, initially delivered at the 14th Yamaguchi (Japan) Symposium on Liver Disease. Its nine chapters present the most recent data about basic and clinical research in hepatology in Japan and other countries, providing a valuable resource for researchers and practitioners alike.

Table of Contents

Preface	v
List of Participants	ix
SAPK/JNK Signaling Participates in Embryonic Hepatoblast Proliferation via a Pathway Different from NF-κB-Induced Anti-Apoptosis
H. NISHINA, T. WATANABE, K. NAKAGAWA, S. OHATA, S. ASAKA, and T. KATADA	1	(14)
Promising Resources of Hepatic Progenitor Cells
S. KAKINUMA, R. CHINZEI, and Y. TANAKA	15	(11)
Oncostatin M. Promotes Differentiation of Fetal Hepatocytes in vitro and Regulates Liver Regeneration in vivo
K. NAKAMURA and A. MIYAJIMA	26	(10)
Hepatocyte Growth Factor Accelerates Proliferation of Hepatic Oval Cells in a 2-Acetylaminofluorene/Partial Hepatectomy Model in the Rat
A. IDO, S. HASUIKE, H. UTO, A. MORIUCHI, and H. TSUBOUCHI	36	(5)
Stem Cells and Liver Repopulation: Current Reality and Prospects for the Future
D.A. SHAFRITZ	41	(10)
Strategy for the Development of Cell Therapy Using Bone Marrow Cells to Repair Damaged Liver
S. TERAI, I. SAKAIDA, N. YAMAMOTO, K. OMORI, and K. OKITA	51	(6)
Bcl-xL as a Critical Apoptosis Antagonist in Hepatocytes and Hepatocellular Carcinoma
T. TAKEHARA and N. HAYASHI	57	(17)
Dedifferentiation and Proliferation of Hepatocellular Carcinoma: From Early to Advanced
M. KOJIRO
Genome-Wide Analysis of Gene Expression in Hepatocellular Carcinoma
T. YAMASHITA, S. KANEKO, M. HONDA, and K. KOBAYASHI	74	(11)
Subject Index	85