Stem Cells and Cancer Stem Cells

by Hayat, M. A.

• ISBN13: 9789400762619
• ISBN10: 9400762615
• Format: Hardcover
• Copyright: 2013-04-05
• Publisher: Springer Nature

Summary

Presenting contributions by 66 experts representing 13 countries, Volume 10 of the series Stem Cells and Cancer Stem Cells synthesizes current understanding of the causes, diagnosis, and cell-based treatment of major human diseases and debilitating tissue and organ injuries, and presents chapters on contemporary research into generation, preservation and uses of stem cells in fighting disease and regenerating tissue. The contents of the volume are organized in five sections. Mesenchymal Stem Cells includes chapters on use of stem cells in bone regeneration; studies and trials of stem cells in autoimmune diseases; and differences between adipose tissue-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells as regulators of immune response. Induced Pluripotent Stem Cells offers chapters on drug discovery using human IPSC-based disease models, and on generation of antigen-specific lymphocytes from IPSCs. Neural Cells and Neural Stem Cells discusses use of bacterial artificial chromosomes in the genetic identification of stem cell-derived neural cell types, and use of moderate low temperature to preserve the stemness of neural stem cells. The section Role of Stem Cells in Disease discusses stem cell support in high-dose chemotherapy of Non-Hodgkin's Lymphomas; potential targets for drug-resistant leukemic stem cells; bone marrow stem cell therapies for diabetes mellitus; and use of stem cells in treating thyroid, breast and bone cancers, hempophilia and Parkinson's Disease. Stem Cell Transplantation includes chapters on reducing fungal infection in allogenic stem cell transplantation patients; use of Bulsufan/Fludarabine for conditioning in haematopoietic stem cell transplantation; and interleukin-7 receptor alpha polymorphisms in allogeneic stem cell transplantation. The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological Sciences at Kean University, Union, New Jersey, USA.