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9780444507310

Stem Cells: A Cellular Fountain of Youth

by ;
  • ISBN13:

    9780444507310

  • ISBN10:

    0444507310

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2002-08-21
  • Publisher: Elsevier Science
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Summary

This volume provides a timely and thorough review of the current state of understanding of a fascinating type of cell that is capable of forming many or all cells in the body. In humans and other mammals embryonic stem cells, the immediate offspring of the fertilized egg, are capable of forming any type of cell in the body. Moreover stem cells are present in many different tissues in adults that are capable of dividing and differentiating into the specific cell types that comprise the organ in which they reside.A major focus of the book is to provide the reader with up-to-date information on the molecular mechanisms that regulate the proliferation, differentiation and survival of stem cells, and how aging and age-related disease impacts on stem cells. Leading authorities detail the properties and therapeutic potential of embryonic stem cells and stem cells of the nervous and immune systems, muscle and bone. Particularly exciting are emerging technologies for using stem cells to treat human age-related diseases including cardiovascular disease, diabetes, neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.This book will be a valuable reference for developmental biologists and for scientists and clinicians who study and treat a variety of diseases.

Table of Contents

Preface vii
Signaling Pathways Influencing Embryonic Stem Cell Self-renewal and Differentiation
1(18)
Thomas. E. Smithgall
Hematopoietic Stem Cells and Aging
19(24)
Gary Van Zant
Erin L. Manning
Hartmut Geiger
Haematopoietic Stem Cells and the Thymus in Aging
43(30)
Amiela Globerson
Plasticity of Adult Bone Marrow Stem Cells
73(24)
Karen J. Chandross
Eva Mezey
Aging Neural Stem Cells
97(20)
Jingli Cai
Mahendra Rao
Stem Cells and Neurodegenerative Disorders
117(24)
Mark P. Mattson
Norman Haughey
Aiwu Cheng
Mahendra S. Rao
Myocardial Aging and Embryonic Stem Cell Biology
141(36)
Kenneth R. Boheler
Anna M. Wobus
Adult Skeletal Muscle Growth and Regeneration: The Development and Differentiation of Myogenic Stem Cells
177(24)
Patrick Seale
Michael A. Rudnicki
Stem Cells In Bone Formation and Remodeling
201(22)
Robert L. Jilka
A. Michael Parfitt
Contributor Addresses 223

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