Stem Cells and Their Potential for Clinical Application

by Bilko, Nadja M.; Fehse, Boris; Ostertag, Wolfram; Stocking, Carol; Zander, Axel R.

• ISBN13: 9781402064678
• ISBN10: 1402064675
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-11-03
• Publisher: Springer Nature

Summary

This book contains contributions of leading international scientists who participated at the NATO-ASI conference 'œStem cells and their potential for clinical application' that was held in Kiev and Simeiz (Ukraine) from August 23 '” 31 , 2006. The articles cover a broad range of hot topics in stem cell and leukaemia research. Those include the potential of various stem cell types in regenerative and transplantation medicine, different mechanisms of malignant transformation leading to leukaemia development, as well as novel clinical strategies for malignant disease treatment such as adoptive immunotherapy with gene-modified lymphocytes. The mixture of articles by principal scientists from Northern America, as well as Eastern and Western Europe, provides a comprehensive overview on 'œWhat's going on?' in various parts of the world in such broadly discussed fields as 'œstem cell research', 'œimmunotherapy' or 'œgene therapy'. Thus, this compilation should be valuable for readers interested in modern biomedicine who have background knowledge in these areas.

Table of Contents

Haematopoietic Stem Cells And Haematopoiesis

Clonal Dominance After Reconstitution of the Haematopoietic System with Bone Marrow Cells Retrovirally Transduced with Murine CD34 Variants

Function of the Membrane-Bound Isoform Ligands of the Receptor Tyrosine Kinase Subclass III in Inducing Self-Renewal of Early Hematopoietic Progenitor Cells

Functional and Phenotypic Heterogeneity of the Human Hematopoietic Stem Cells (HSC) Compartment

Alterations of Frequency of Hematopoietic Precursors in Mice Subjected to Multiple Courses of Low-Dose G-CDF Injections

Regulation of Hematopoiesis by Growth Factors

Biology Of Non-Haematopoietic Stem Cells

Stem Cell Technologies in Gerontological Research

Osteopetrotic Models for Identifying Genes that Control Bone Resorption

Non-Hematopoietic Bone Marrow Cells for Regenerative Medicine

Epithelial Plasticity of Hepatocytes during Liver Tumor Progression

Blood Vessels as a Source of Progenitor Cells in Human Embryonic and Adult Life

Stem Cells and Malignancy

Stem Cells and Leukemia

Telomere and Stem Cell Biology in Chronic Myeloid Leukemia

Potential Immune Escape Mechanisms of Tumors: MHC Class I Molecules - Enemies or Friends

The RUNXI Transcription Factor: A Gatekeeper in Acute Leukemia

Cell Processing, Expansion And Genetic Modification

Novel Methodological Approaches in Assessment and Enrichment of Stem Cell Population

Animal Hybrids and Stem Cells Their Use in Biotechnology and Clinical Practice

Cryopreservation of Stem Cells

The M813 Retrovirus Belongs to a Unique Interference Group and is highly Fusogenic

Reconstructing an Anti-Tumor Immune Repertoire for Targeted AML Therapy

Clinical Haematopoietic Stem Cell Transplantation

Experience of Kyiv Center of Stem Cell Transplantation

Anti Thymocyte Globuline Allows for Successful Transplantation from HLA Mismatched Unrelated Donors

Table of Contents provided by Publisher. All Rights Reserved.