Sterile Compounding

by Moini, Jahangir; Enabulele, Obehi; Scott, Anthony

• ISBN13: 9780357766040
• ISBN10: 0357766040
• Edition: 1st
• Format: Paperback
• Copyright: 2023-03-23
• Publisher: Cengage Learning

Table of Contents

1. INTRODUCTION. Overview. History of Sterile Compounding. Requirements for Sterile Compounding. Types of Sterile Compounding. Hospital Pharmacy Compounding. Ambulatory Care Compounding. Nuclear Pharmacy Compounding. Factors Affecting Sterile Compounding. Stability. Temperature. Pressure and Humidity. Growth Media. Key Terms. References. 2. SAFETY IN THE WORKPLACE . Overview. Occupational Safety and Health Administration (OSHA). OSHA Standards. The Hazard Communication Standard. The Bloodborne Pathogen Standard. Fire Safety and Emergency Plan. Environmental Pollution. Latex Allergy. Work-Related Musculoskeletal Disorders. Exposure Reduction to Chemotherapeutic Agents. Safe Handling of Cytotoxic and Hazardous Medications. Cleaning Up a Spill. Hazardous Waste Management. Defining Hazardous Waste. Disposal of Hazardous Wastes. Key Terms. References. 3. EQUIPMENT, GARMENTS, AND GOWNING. Overview. Equipment. Syringes. Needles. Ampules. Vials. Filters. Intravenous Tubing. Vented Tubing. Intravenous Bags. Dispensing Pins. Port Adapters. Vented Spike Adapters. Auxiliary Labels. Sharps Containers. Refrigerators. Freezers. Computer Terminals and Software. Carts. Locker Facilities. Miscellaneous Equipment. Balances. Warming Cabinets. Garments. Gowns. Gloves. Face Masks. Shoe Covers. Gowning. Gowning Techniques. Key Terms. References. 4. ASEPTIC TECHNIQUE AND CLEAN ROOMS. Overview. Microorganisms. Bacteria. Viruses. Types of Infections. Methods of Transmission. Personnel. Environment. Instruments. Principles of Asepsis. Medical Asepsis. Hand Hygiene. Cleaning and Disinfection. Aseptic Technique. Key Terms. References. 5. LAMINAR AIRFLOW WORKBENCHES. Overview. Clean Rooms. Ante Area. Buffer Area. Containment Segregated Compounding Area. Segregated Compounding Area. Clean Air Environments. Laminar-Airflow Hoods. Types of Laminar Airflow Systems. Cleaning of Hoods and Clean Rooms. Key Terms. References. 6. PHARMACY CALCULATIONS. Overview. Dosage. Powder Volume. Flow Rates. Key Terms. References. 7. STERILE COMPOUNDING AND PREPARATIONS. Overview. Personal Training. Parenteral Preparations. Non-injectable Products. Dialysis Solutions. Irrigations. Ophthalmics. Intravenous Products. Small-Volume Parenteral. Large-Volume Parenteral. Total Parenteral Nutrition. Factors Affecting Parenteral Products. Administration Techniques. Intermittent Infusion. Continuous Infusion. Rapid Direct Injection. Intravenous Therapy Equipment. Preparation of Parenteral Products. Laminar-Airflow Hoods. Role of the Technician. U.S. Pharmacopeia (USP) Chapter <797>. Compounding Records. Policies and Procedures for Sterile Product Preparation. Procedures for Handling and Preparing Parenteral Products. Visual Inspection of the Parenteral Product. Preparation of IV Admixtures. Compounding a TPN Product. Preparing an IV Piggyback. Key Terms. References. 8. UNITED STATES PHARMACOPEIA (USP). Overview. USP <797> Pharmaceutical Compounding - Sterile Preparations. USP <800> Hazardous Drugs. USP <825> Radiopharmaceuticals. Key Terms. References. 9. REPACKAGING, LABELING, STORAGE, DISPOSAL. Overview. Repackaging of Drugs. Special Packaging Requirements. Unit-Dose System. Single-Unit Packaging. Single-Dose Packaging. Repackaging Equipment. Packaging of Oral Solid Systems. Packaging of Oral Liquid Systems. Commonly Repackaged Drugs. Oral Liquids. Topical Drugs. Labeling. Record Keeping. Storage. Disposal. Key Terms. References. 10. RECORD-KEEPING REQUIREMENTS. Overview. Training and Competency Evaluations. Results of Hand Hygiene and Garbing. Aseptic Technique. Results of Viable Air and Surface Sampling. Biannual Clean Room Airflow Tests. Room Temperature Documentation. Refrigerator Temperature Documentation. Freezer Temperature Documentation. Sterile Compounding Area Documentation. Daily Air Pressure and Velocity Documentation. Facility and Equipment Cleaning Logs. Documentation of Expired or Recalled Substances. Master Formula Document. Preparation Compounding Log. End-Product Evaluation Testing. Key Terms. References. 11. QUALITY CONTROL AND ASSURANCE. Overview. Policies and Procedures. Influencing Factors. Medication Errors. Quality Improvement. Agency Guidelines. Food and Drug Administration. American Society of Health System Pharmacists. The Joint Commission on Accreditation of Healthcare Organizations. Center for Drug Evaluation and Research. American Medical Association. Centers for Disease Control and Prevention. Role of the Pharmacy Technician. Key Terms. References. Appendix A: Examples of Compounding Formulas. Appendix B: Sample Practitioners for Sterile Compounding. Answer Keys. Glossary. Index.