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Professor Satyajit D Sarker BPharm (Hons) MPharm PhD FHEA, Professor of Pharmacy, Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, UK
Professor Sarker is the author of Natural Products Isolation (Humana Press), and, with Dr Nahar, of Chemistry for Pharmacy Students (Wiley). His research interests include the isolation, characterisation, bioactivity and mode of action of bioactive natural products, the metabolomics of medicinal plants, and quality control of herbal medicines.
Dr Lutfun Nahar BSc (Hons) PhD MRSC
Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, UK.
Preface | p. ix |
List of Abbreviations | p. xi |
Introduction | p. 1 |
Steroids and Steroid Dimers | p. 1 |
General Physical and Spectroscopic Properties of Steroid Dimers | p. 2 |
Chromatographic Behaviour of Steroid Dimers | p. 5 |
Applications of Steroid Dimers | p. 6 |
References | p. 6 |
Synthesis of Acyclic Steroid Dimers | p. 7 |
Dimers via Ring A-Ring A Connection | p. 7 |
Direct Connection | p. 7 |
Through Spacer Groups | p. 21 |
Dimers via Ring B-Ring B Connection | p. 68 |
Direct Connection | p. 68 |
Through Spacer Groups | p. 74 |
Dimers via Ring C-Ring C Connection | p. 84 |
Through Spacer Groups | p. 84 |
Dimers via Ring D-Ring D Connection | p. 87 |
Direct Connection | p. 87 |
Through Spacer Groups | p. 89 |
Through Side Chain and Spacer Groups | p. 100 |
Dimers via Ring A-Ring D Connection | p. 151 |
Direct Connection | p. 151 |
Dimers via Connection of C-19 | p. 169 |
Molecular Umbrellas | p. 170 |
Miscellaneous | p. 174 |
References | p. 182 |
Synthesis of Cyclic Steroid Dimers | p. 187 |
With Spacer Groups: Cholaphanes | p. 187 |
Without Spacer Groups: Cyclocholates | p. 232 |
References | p. 238 |
Naturally Occurring Steroid Dimers | p. 241 |
Cephalostatins | p. 242 |
Crellastatins | p. 254 |
Ritterazines | p. 262 |
Others | p. 277 |
References | p. 284 |
Synthesis of Cephalostatin and Ritterazine Analogues | p. 287 |
Introduction | p. 287 |
Synthesis of Cephalostatin and Ritterazine Analogues | p. 288 |
Total Synthesis of Naturally Occurring Cephalostatin 1 | p. 371 |
References | p. 376 |
Applications of Steroid Dimers | p. 379 |
Application of Steroid Dimers as 'Molecular Umbrellas': Drug Delivery | p. 379 |
Biological and Pharmacological Functions of Steroid Dimers: Drug Discovery and Design | p. 382 |
Antimalarial Activity | p. 383 |
Cytotoxicity and Anticancer Potential | p. 386 |
Effect on Micellar Concentrations of Bile Salts and Serum Cholesterol Level | p. 401 |
Effect on Bilayer Lipid Membranes | p. 402 |
Supramolecular Transmembrane Ion Channels, and Artificial Receptors and Ionophores | p. 402 |
Other Properties | p. 404 |
References | p. 405 |
Index | p. 409 |
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