Strategies for Organic Drug Synthesis and Design, 2nd Edition

by Daniel Lednicer (Analytical Bio-Chemistry Laboratories, Inc., Columbia, Missouri)

• ISBN13: 9780470399590
• ISBN10: 0470399597
• Format: eBook
• Copyright: 2009-03-01
• Publisher: Wiley-Interscience

Summary

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

Table of Contents

Preface

PROSTAGLANDINS, PEPTIDOMIMETIC COMPOUNDS, AND RETINOIDS.

Prostaglandnis

Peptidonimetic Compounds

Retinoids

A Miscellaneous Drug

References

DRUG BASED ON A SUBSTITUTED BENZENE RING

Arylethanolamines

Aryloxypropanolamines

Arylsulfonic Acid Derivatives

Arylacetic and Arylpropionic Acids

INDENES, NAPHTHALENES AND OTHER POLYCYCLIC AROMATIC COMPOUNDS

Indenes

Naphthalenes

Partly Reduced Naphthalenes

Tricyclic Compounds

References

STEROIDS; PART 1: ESTRANES, GONANES, AND ANDROSTANES

Introduction

Steroid Starting Materials

Estranes

Gonanes, the 19-nor Steroids

Androstanes

References

STEROIDS; PART 2: COMPOUNDS RELATED TO PROGESTERONE, CORTISONE, AND CHOLESTEROL.

Introduction

Progestins

Corticosteroids

Compounds Derived from Cholesterol

References

NONSTEROIDAL SEX HORMONES AND THEIR ANTAGONISTS

Introduction

Estrogens

References

OPIOID ANAlGESICS

Introduction

Drugs Derived from Morphine

Compounds Prepared from Thebaine

Morphinans

Benzomorphans

Analgesics Based on Nonfused Piperidines

References

DRUGS BASED ON FIVE-MEMBERED HETEROCYCLES

Introduction

Rings that Contain One Heteroatom

Rings that Contain Two Heteroatoms

Rings that Contains Three or More Heteroatoms

References

DRUGS BASED ON SIX-MEMBERED HETEROCYCLES.

Rings that Contain One Heteroatom

Rings that Contain Two Heteroatoms

Rings Containing Three Heteroatoms: The Triazines

References

FIVE-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING.

Compounds that Contain One Heteroatom

Compounds that Contain Two Heteroatoms

Compounds that Contain Three Heteroatoms

References

SIX-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING

Compounds that Contain One Heteroatom

Compounds that Contain Two Heteroatoms

Compounds that Contain Three Heteroatoms

References

SEVEN-MEMBERED HETEROCYCLIC FUSED TO BENZENE.

Compounds with a Single Heterocyclic Atom

Compounds with Two Heteroatoms

References

HETEROCYLES FUSED TO TWO AROMATIC RINGS

Compounds Containing a Single Heteroatom

Compounds Containing Two Heteroatoms

Pyridine-Based Fused Tricyclic Compounds

References

BETA LACTAM ANTIBIOTICS

Penicillins

Cephalosporins

Monobactams

References

HETEROCYCLES FUSED TO OTHER HETEROCYCLIC RINGS.

Two Fused Five-Membered Rings

Five-Membered Heterocycles Fused to Six-Membered Rings

Two Fused Six-Membered Rings

Heterodiazepines

Heterocyclic Compounds with Three or More Rings

References

Subject Index

Reaction Index

Cross Index of Biological Activities

Table of Contents provided by Publisher. All Rights Reserved.