Stress, the Brain and Depression

by Van Praag, H. M.; De Kloet, E. R.; Van Os, J.

• ISBN13: 9781107406919
• ISBN10: 1107406919
• Edition: Reprint
• Format: Paperback
• Copyright: 2012-09-19
• Publisher: Cambridge Univ Pr

Summary

Can traumatic life events cause depression? Studies generally point to a connection between adverse life events and depression. However, establishing a causal rather than associative connection, the key concern of this 2004 book, is more problematic. What neurobiological changes may be induced by stress and depression, and to what extent do these changes correspond? The authors structure their examination around three major themes: the pathophysiological role of stress in depression; whether or not a subtype of depression exists that is particularly stress-inducible; and, finally, how best to diagnose and treat depression in relation to its biological underpinnings.

Table of Contents

Introduction

Diagnosing depression

Traumatic life events: general issues

Life events and depression: preliminary issues

Life events and depression: is there a causal connection

Genetics and depression Jim van Os

Gene-environment correlation and interaction in depression Jim van Os

Monomines and depression

Stress hormones and depression Ron de Kloet and Herman van Praag

Stress, the brain and depression

Epilogue

Index

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