Stroke: Pathophysiology, Diagnosis, and Management

by Mohr, J. P.; Wolf, Philip A., M.D.; Grotta, James C., M.D.; Moskowitz, Michael A.; Mayberg, Marc R., M.D.

• ISBN13: 9781416054788
• ISBN10: 1416054782
• Edition: 5th
• Format: Hardcover
• Copyright: 2011-03-31
• Publisher: Elsevier Science Health Science

Summary

First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more, equipping you to understand the latest scientific discoveries and make effective use of the newest approaches to diagnosis and treatment. Plus, a new organization and new full-color images make diagnosis easier and more efficient, and full-text online access at www.expertconsult.com allows you to rapidly search this indispensible reference from any computer. Gain fresh perspectives and up-to-date insights from the world's leading authorities on the pathophysiology, diagnosis, and management of stroke.Access the comprehensive, expert clinical guidance you need to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan.Make efficient and accurate diagnoses with the aid of abundant full-color CT images and pathology slides.Stay up to date on hot topics such as mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more.Search the complete text online at www.expertconsult.com to quickly find the answers you need, download images, and follow links to PubMed abstracts for most references.Combat the increasing prevalence of stroke with the most comprehensive and updated multimedia resource on the pathophysiology, diagnosis, and management of stroke from leading authority Dr. Mohr.

Table of Contents

Pathophysiology
Vascular Biology and Atherosclerosis of Cerebral Arteries	p. 03
The Cerebral Microvasculature and Responses to Ischemia	p. 16
Mechanisms of Thrombosis and Thrombolysis	p. 29
Cerebral Blood Flow and Metabolism in Human Cerebrovascular Disease	p. 44
Histopathology of Cerebral Ischemia	p. 68
Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death	p. 75
Apoptosis and Related Mechanisms in Cerebral Ischemia	p. 107
Molecular Pathophysiology of White Matter Anoxic-Ischemic Injury	p. 122
Cerebral Ischemia and Inflammation	p. 138
Intracellular Signaling: Mediators and Protective Responses	p. 154
Enhancing Brain Reorganization and Recovery of Function after Stroke	p. 162
Genetics and Vascular Biology of Brain Vascular Malformations	p. 169
Epidemiology and Prevention
Distribution of Stroke: Heterogeneity by Age, Race, and Sex	p. 189
Epidemiology of Stroke	p. 198
Prognosis after Stroke	p. 219
Primary Prevention of Stroke	p. 242
Vascular Dementia and Vascular Cognitive Decline	p. 252
Stroke Genetics	p. 268
The Global Burden of Stroke	p. 279
Clinical Manifestations
Classification of Ischemic Stroke	p. 293
Clinical Scales to Assess Patients with Stroke	p. 307
Carotid Artery Disease	p. 334
Anterior Cerebral Artery Disease	p. 362
Middle Cerebral Artery Disease	p. 384
Posterior Cerebral Artery Disease	p. 425
Vertebrobasilar Disease	p. 446
Microangiopathies (Lacunes)	p. 485
Cerebral Venous Thrombosis	p. 516
Intracerebral Hemorrhage	p. 531
Aneurysmal Subarachnoid Hemorrhage	p. 589
Arteriovenous Malformations and Other Vascular Anomalies	p. 616
Spinal Cord Ischemia	p. 643
Specific Medical Diseases and Stroke
Arterial Dissections and Fibromuscular Dysplasia	p. 661
Collagen Vascular and Infectious Diseases	p. 687
Moyamoya Disease	p. 703
Migraine and Stroke	p. 720
Hypertensive Encephalopathy	p. 734
Atherosclerotic Disease of the Proximal Aorta	p. 741
CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy	p. 758
Reversible Cerebral Vasoconstriction Syndromes	p. 765
Coagulation Abnormalities in Stroke	p. 772
Stroke and Substance Abuse	p. 790
Cardiac Diseases	p. 814
Diagnostic Studies
Ultrasonography	p. 831
Computed Tomography-Based Evaluation of Cerebrovascular Disease	p. 870
Magnetic Resonance Imaging of Cerebrovascular Diseases	p. 882
Cerebral Angiography	p. 910
Therapy
Medical Therapy
Prehospital and Emergency Department Care of the Patient with Acute Stroke	p. 929
Intravenous Thrombolysis	p. 945
Antithrombotic Therapy for Treatment of Acute Ischemic Stroke	p. 971
General Stroke Management and Stroke Units	p. 992
Critical Care of the Patient with Acute Stroke	p. 1008
Pharmacologic Modification of Acute Cerebral Ischemia	p. 1049
Treatment of "Other" Stroke Etiologies	p. 1084
Medical Therapy of Intracerebral and Intraventricular Hemorrhage	p. 1106
Rehabilitation and Recovery of the Patient with Stroke	p. 1116
Enhancing Stroke Recovery with Cellular Therapies	p. 1134
Antiplatelet Therapy for Secondary Prevention of Stroke	p. 1147
Secondary Prevention of Cardioembolic Stroke	p. 1173
Conduct of Stroke-Related Clinical Trials	p. 1192
Interventional Therapy
Interventional Neuroradiologic Therapy of Atherosclerotic Disease and Vascular Malformations	p. 1204
Intraarterial Thrombolysis in Acute Ischemic Stroke	p. 1227
Endovascular Treatment of Cerebral Aneurysms	p. 1241
Interventional Therapy of Brain and Spinal Arteriovenous Malformations	p. 1255
Dural Arteriovenous Malformations	p. 1280
Surgical Therapy
Genetics of Aneurysms and Arteriovenous Malformations	p. 1292
Anterior Circulation Aneurysms	p. 1301
Surgical Management of Posterior Circulation Aneurysms	p. 1322
Surgery for Intracerebral Hemorrhage	p. 1336
Intraventricular Hemorrhage	p. 1349
Surgical Decision Making, Techniques, and Periprocedural Care of Cerebral Arteriovenous Malformations	p. 1358
Spinal Arteriovenous Malformations	p. 1366
Radiosurgery for Arteriovenous Malformations	p. 1374
Cerebral Cavernous Malformations and Venous Anomalies: Diagnosis, Natural History, and Clinical Management	p. 1388
Indications for Carotid Endarterectomy in Patients with Symptomatic Stenosis	p. 1398
Surgical Management of Asymptomatic Carotid Stenosis	p. 1403
Extracranial to Intracranial Bypass for Cerebral Ischemia	p. 1417
Cerebral Infarction: Surgical Treatment	p. 1426
Cerebellar Infarction and Hemorrhage	p. 1440
Index	p. 1447
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