Structural Biology of Viruses

by Chiu, Wah; Burnett, Roger M.; Garcea, Robert

• ISBN13: 9780195086270
• ISBN10: 0195086279
• Format: Hardcover
• Copyright: 1997-07-03
• Publisher: Oxford University Press

Summary

Historically, structural biology and virology have been separate disciplines, with the field of virology developing around particular virus families. However, recent advances in the techniques of structural biology, including high-performance computing and graphics visualization, X-ray crystallography, and electron microscopy, coupled with continued progress in molecular biology and virology have caused a major convergence of interests. "Structural virology" now provides some of the most outstanding examples of structure-function relationships in biology. Viruses encounter many common problems in their life cycles, and so the solutions that they have evolved provide instructive contrasts between different biological strategies for survival. These ideas are illustrated by each of the different chapters, most of which cover a viral system that well illustrates a particular biological function. The goal of this book is to unite the structural and biological aspects of virus function. With this in mind, each chapter has been written explicitly by experts to address a broad audience ranging from graduate students to researchers in structural biology, virology, molecular biology, and biochemistry.

Table of Contents

Introduction	xi
Robert L. Garcea
Roger M. Burnett
Wah Chiu
1. Principles of Virion Structure, Function, and Assembly	3	(35)
Sherwood Casjens
2. Principles of Virus Structure Determination	38	(42)
Timothy S. Baker
John E. Johnson
3. Attachment and Entry of Influenza Virus into Host Cells: Pivotal Roles of the Hemagglutinin	80	(25)
Judith M. White
Lucas R. Hoffman
Jairo H. Arevalo
Ian A. Wilson
4. Rhinovirus Attachment and Cell Entry	105	(29)
Michael G. Rossmann
Jeffrey M. Greve
Prasanna R. Kolatkar
Norman H. Olson
Thomas J. Smith
Mark A. McKinlay
Roland R. Rueckert
5. Antibody-Mediated Neutralizaiton of Picornaviruses	134	(23)
Thomas J. Smith
Anne G. Mosser
6. The Role of Conformational Transitions in Poliovirus Pathogenesis	157	(30)
Marie Chow
Ravi Basavappa
James M. Hogle
7. Structural Biology of Polyomaviruses	187	(22)
Robert L. Garcea
Robert C. Liddington
8. The Structure of Adenovirus	209	(30)
Roger M. Burnett
9. Molecular Basis of Rotavirus Replication: Structure-Function Correlations	239	(30)
B.V. Venkataram Prasad
Mary K. Estes
10. Packaging and Release of the Viral Genome	269	(19)
John E. Johnson
Roland R. Rueckert
11. The Procapsid-to-Capsid Transition in Double-Stranded DNA Bacteriophages	288	(24)
Jonathan King
Wah Chiu
12. Herpesvirus Capsid Assembly and Envelopment	312	(40)
Alasdair C. Steven
Patricia G. Spear
13. Structure and Assembly of Filamentous Bacteriophages	352	(29)
Lee Makowski
Marjorie Russel
14. Molecular Requirements for Retrovirus Assembly	381	(30)
Robert A. Weldon, Jr.
Eric Hunter
15. Structure-Guided Therapeutic Strategies	411	(21)
Gillian M. Air
Ming Luo
16. The Use of Structural Information in the Design of Picornavirus Capsid Binding Agents	432	(19)
Guy D. Diana
Mark A. McKinlay
Adi Treasurywala
17. Rational Design of HIV Protease Inhibitors	451	(24)
C. Nicholas Hodge
T.P. Straatsma
J. Andrew McCammon
Alexander Wlodawer
Index	475