Structural Biology of Viruses

by Chiu, Wah; Burnett, Roger M.; Garcea, Robert

• ISBN13: 9780195118506
• ISBN10: 0195118502
• Format: Paperback
• Copyright: 1997-07-30
• Publisher: Oxford University Press

Summary

Historically, structural biology and virology have been separate disciplines, with the field of virology developing around particular virus families. However, recent advances in the techniques of structural biology, including high-performance computing and graphics visualization, X-ray crystallography, and electron microscopy, coupled with continued progress in molecular biology and virology have caused a major convergence of interests. "Structural virology" now provides some of the most outstanding examples of structure-function relationships in biology. Viruses encounter many common problems in their life cycles, and so the solutions that they have evolved provide instructive contrasts between different biological strategies for survival. These ideas are illustrated by each of the different chapters, most of which cover a viral system that well illustrates a particular biological function. The goal of this book is to unite the structural and biological aspects of virus function. With this in mind, each chapter has been written explicitly by experts to address a broad audience ranging from graduate students to researchers in structural biology, virology, molecular biology, and biochemistry.

Table of Contents

Introduction

Sherwood Casjens: Principles of Virion Structure, Function and Assembly

Principles of Virus Structure Determination

Attachment and Entry of Influenza Virus Into HostCells: Pivotal Roles of the Hernagglutin

Rhinovirus Attachment and Cell Entry

Antibody Mediated Neutralization of Picornaviruses

The Role of Conformational Transitions in Poliovirus Pathogenesis

Structural Biology of Polyomaviruses

The Structure of Adenovirus

Molecular Basis of Rotavirus Replication:Structure-Function Correlations

Packaging and Release of the Viral Genome

The Procapsid to Capsid Transition in Double-Stranded DNA Bacteriophages

Herpesvirus Capsid Assembly and Envelopment

Structure and Assembly of Filamentous Bacteriophages

Molecular Requirements for Retrovirus Assembly

Structure-Guided Therapeutic Strategies:General Overview

The Use of Structural Information in the Design of Picornavirus Capsid Binding Agents

Rational Design of HIV Protease Inhibitors

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