Studies in Fetal Behavior Revisited, Renewed, and Reimagined

by DiPietro, Janet A.; Costigan, Kathleen A.; Voegtline, Kristin M.; Brakke, Karen; Sandman, Curt A.; Bauer, Patricia J.

• ISBN13: 9781119186267
• ISBN10: 1119186269
• Edition: 3rd
• Format: Paperback
• Copyright: 2015-07-27
• Publisher: Wiley-Blackwell

Summary

Among the earliest volumes of this monograph series was a report by Lester Sontag and colleagues, of the esteemed Fels Institute, on the heart rate of the human fetus as an expression of the developing nervous system. Here, some 75 years later, we commemorate this work and provide historical and contemporary context on knowledge regarding fetal development, as well as results from our own research. These are based on synchronized monitoring of maternal and fetal parameters assessed between 24 and 36 weeks gestation on 740 maternal-fetal pairs compiled from eight separate longitudinal studies, which commenced in the early 1990s. Data include maternal heart rate, respiratory sinus arrhythmia, and electrodermal activity and fetal heart rate, motor activity, and their integration. Hierarchical linear modeling of developmental trajectories reveals that the fetus develops in predictable ways consistent with advancing parasympathetic regulation. Findings also include: within-fetus stability (i.e., preservation of rank ordering over time) for heart rate, motor, and coupling measures; a transitional period of decelerating development near 30 weeks gestation; sex differences in fetal heart rate measures but not in most fetal motor activity measures; modest correspondence in fetal neurodevelopment among siblings as compared to unrelated fetuses; and deviations from normative fetal development in fetuses affected by intrauterine growth restriction and other conditions. Maternal parameters also change during this period of gestation and there is evidence that fetal sex and individual variation in fetal neurobehavior infl uence maternal physiological processes and the local intrauterine context. Results are discussed within the framework of neuromaturation, the emergence of individual differences, and the bidirectional nature of the maternal-fetal relationship. We pose a number of open questions for future research. Although the human fetus remains just out of reach, new technologies portend an era of accelerated discovery of the earliest period of development.

Author Biography

Janet A. DiPietro, Ph.D. is the Associate Dean for Research & Faculty at the Johns Hopkins Bloomberg School of Public Health and a Professor in the Department of Population, Family, and Reproductive Health. As a developmental psychologist, her interests focus on the degree to which individual differences in psychobiology and psychophysiology intersect with behavior and development. Her work documents normative development before birth and evaluates the role of maternal exposures on fetal development in an effort to understand the manner in which the fetal period provides the substrate for later life.

Kathleen A. Costigan, R.N., M.P.H. directs the Fetal Assessment Center within the Department of Gynecology & Obstetrics of the Johns Hopkins Hospital. Her interests involve the application of fetal surveillance methodologies to clinical and research evaluation of fetal development and well-being. She has been a collaborator on the Johns Hopkins Fetal Neurobehavioral Development project since its inception.

Kristin M. Voegtline, Ph.D. is a postdoctoral research fellow in the Department of Population, Family, and Reproductive Health at Johns Hopkins Bloomberg School of Public Health. Her research interests lie in developmental psychobiology, with a focus on the organizational effects of the prenatal period on postnatal physiological and behavioral regulation. Karen Brakke, Ph.D. is Associate Professor of Psychology at Spelman College. Her research interests focus on skill development in infancy and early childhood, with particular emphasis on object manipulation and bimanual coordination. She is also active in the Scholarship of Teaching and Learning (SoTL) community.

Curt A. Sandman, Ph.D. is Professor Emeritus at the University of California, Irvine and currently is Principal Investigator of a project in a 5-year Conte Center award from the NIMH to examine Brain Programming of AdolescentVulnerabilities. Professor Sandman has maintained an NIH funded research program for over 28 consecutive years and has published over 300 scientific papers. He has been Principal Investigator for a consecutive series of studies that examined the “programming” effects of stress and activation of the HPA/placental axis on the human fetus, birth outcomes infant, and child development.

Table of Contents

ABSTRACT vii

I FETAL DEVELOPMENT RESEARCH IN CONTEXT: SEVENTY-FIVE YEARS OF INFLUENCE OF THE FELS LONGITUDINAL STUDY 1

II. WHY STUDY THE FETUS? 3

III. METHODS TO MONITOR THE FETUS 11

IV. DESCRIPTION OF OUR RESEARCH PROGRAM 14

V. FETAL HEART RATE AND VARIABILITY 23

VI. FETAL MOTOR ACTIVITY 33

VII. INTEGRATION OF FETAL MOVEMENT AND FETAL HEART RATE 43

VIII. THE MATERNAL CONTEXT 50

IX. SEX DIFFERENCES IN FETAL DEVELOPMENT 59

X. SIBLINGS 66

XI. DEVIATIONS FROM NORMAL DEVELOPMENT 71

XII. GENERAL DISCUSSION 77

XIII. FETAL NEUROBEHAVIORAL RESEARCH REIMAGINED 84

REFERENCES 95

ACKNOWLEDGMENTS 113

COMMENTARIES

STORY AND HISTORY IN FETAL BEHAVIOR 114
Karen Brakke

MYSTERIES OF THE HUMAN FETUS REVEALED 124
Curt A. Sandman

CONTRIBUTORS 138

STATEMENT OF EDITORIAL POLICY 140

SUBJECT INDEX 142