Synapses

by Cowan, W. Maxwell

• ISBN13: 9780801871184
• ISBN10: 0801871182
• Edition: 1st
• Format: Paperback
• Copyright: 2003-03-18
• Publisher: Johns Hopkins Univ Pr

Summary

Edited by W. Maxwell Cowan, Thomas C. Südhof, and Charles F. Stevens, this volume provides a comprehensive and authoritative overview of a century of research on synaptic structure and function culminating in the most recent work. Written by leading experts in the field, Synapses will be of interest to a broad range of neuroscientists, including those studying the cellular and molecular mechanisms of synaptic transmission, learning and memory, neuronal plasticity, neurotransmitters, and synaptic morphology. It will also be an essential reference for students and biomedical professionals in all areas of neuroscience.

Author Biography

W. Maxwell Cowan (1932-2002) was an internationally renowned neurobiologist and the chief scientific officer at the Howard Hughes Medical Institute (HHMI) in Chevy Chase, Maryland. Thomas C. S++dhof is an HHMI investigator and professor of molecular genetics at the University of Texas Southwestern Medical Center at Dallas. Charles F. Stevens is an HHMI investigator at the Salk Institute for Biological Studies and adjunct professor of Pharmacology and of Neuroscience at the University of California, San Diego, School of Medicine.

Table of Contents

Preface	vii
Contributors	xi
A Brief History of Synapses and Synaptic Transmission	1	(88)
W. Maxwell Cowan
Eric R. Kandel
The Structure of Synapses	89	(46)
Pietro De Camilli
Volker Haucke
Kohji Takei
Enrico Mugnaini
Physiology of Synaptic Transmission and Short-Term Plasticity	135	(42)
Wade G. Regehr
Charles F. Stevens
Mechanism and Regulation of Neurotransmitter Release	177	(40)
Thomas C. Sudhof
Richard H. Scheller
Synaptic Vesicle Endocytosis	217	(58)
Pietro De Camilli
Vladimir I. Slepnev
Oleg Shupliakov
Lennart Brodin
The Synaptic Cleft and Synaptic Cell Adhesion	275	(40)
Thomas C. Sudhof
The Postsynaptic Specialization	315	(42)
Morgan H.-T. Sheng
Signal Transduction in the Postsynaptic Neuron	357	(36)
Activity-Dependent Regulation of Gene Expression
Michael E. Greenberg
Edward B. Ziff
Synaptic Plasticity	393	(62)
Diverse Targets and Mechanisms for Regulating Synaptic Efficacy
Robert C. Malenka
Steven A. Siegelbaum
The Mechanisms and Meaning of Long-Term Synaptic Depression in the Mammalian Brain	455	(64)
Mark F. Bear
David J. Linden
Synaptic Plasticity and Memory	519	(52)
Paul D. Grimwood
Stephen J. Martin
Richard G. M. Morris
Synapse Formation and Maturation	571	(42)
Ann Marie Craig
Jeff W. Lichtman
Neurotrophins and Refinement of Visual Circuitry	613	(38)
Edward S. Lein
Carla J. Shatz
Novel Neurotransmitters and Their Neuropsychiatric Relevance	651	(30)
Solomon H. Snyder
Christopher D. Ferris
Synaptic Variability	681	(52)
New Insights from Reconstructions and Monte Carlo Simulations with MCell
Joel R. Stiles
Thomas M. Bartol
Miriam M. Salpeter
Edwin E. Salpeter
Terrence J. Sejnowski
Index	733