Systemic Lupus Erythematosus

by Tsokos, George C.

• ISBN13: 9780323044349
• ISBN10: 0323044344
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-01-01
• Publisher: MOSBY-YEAR BOOK INC

Summary

This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, youll find one stop coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAPs, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.

Table of Contents

Epidemiology and Diagnosis

Epidemiology

Disease Activity Measures

Disease Outcome

Quality of Life and Economic Aspects Pathogenesis

Overview of the Pathogenesis of SLE

Genetics

Hormones

Immunoregulation T Cells, B cells, and cytokines

Cell Surface Receptors ostimulation/BAFF/FcgR/TLRs)

Dendritic Cells

Apoptosis

Structure and Origin of Autoantibodies

Animal Models

Genetics of murine lupus

Infection and autoimmunity Mechanisms of Tissue Damage

Complement

Immune complexes

Antibodies

ANA and standardization of antibody techniques

Anti-DNA

Anti-splicesomosal ab

Anti-Ro/La

Anti-Histone

APL

Anti-neuronal

PMNs

Mechanisms of renal damage

Mechanisms of vascular damage

Nitric Oxide Clinical Aspects of the Disease

Constitutional Symptoms and Fatigue

Skin

Kidney

Heart

Lung

GI/liver/pancreas

Infections

Blood (anti-phospholipid syndrome)

Nervous System

Overlap Syndromes

Ophthalmic Manifestations

Pregnancy

Fertility

Neo-natal lupus

Hereditary and Malignant Lupus-like Diseases Treatment of the Disease

Non-Steroidals Anti-Malarials and Statins

Steroid Treatment

Cytotoxic Drug Treatment including M.M.F

PAPS

New Treatments

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