Systemic Lupus Erythematosus

by Lahita

• ISBN13: 9780123749949
• ISBN10: 0123749948
• Edition: 5th
• Format: Hardcover
• Copyright: 2010-11-02
• Publisher: Elsevier Science

Summary

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disease which can involve every organ system of the human body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission.Lupus is the prototypic autoimmune disease and Systemic Lupus Erythematosus examines the entire field of autoimmunity by looking at lupus. There is no other book in the field which carefully covers scientific research, clinical findings, organ system involvement and treatment between its two covers. The fifth edition continues to serve as a vital translational reference for specialists in the diagnosis and management of patients with SLE, and as a key a tool for the measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. * Highly illustrated and in full color throughout * Basic science section expanded, allowing the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment * Clinical aspects and new drugs are covered in great detail providing a useful reference to professionals interested in lupus

Table of Contents

Basis of Disease Pathogenesis

Genetics

Major histocompatibility complex class II

Genetic susceptibility and class III complement genes

Constitutive genes and lupus

Genetics of lupus in mice

Tolerance and autoimmunity

Dendritic cells in SLE

T cells and systemic lupus erthematosus

B-lymphocyte biology in SLE

Polymorhonuclear and endothelial cells

Mechanisms and consequences of mitochondrial dysfunction and oxidative stress in T cells of patients with SLE

Cell cycle regulation and systemic lupus erythematosus

The role of reactive nitrogen and oxygen intermediates in systemic lupus erythematosus

Origins of antinuclear antibodies

Anti-DNA antibodies: Structure, regulation and pathogenicity

Extractable nuclear antigens and SLE: specificity and role in disease pathogenesis

Antihistone and antispliceosomal antibodies

Toll-like receptors in SLE

Interferon-alpha in systemic lupus erythematosus

Immune complexes in systemic lupus erythematosus

Complement and tissue injury in SLE

Humoral pathogenesis: Fc receptors in autoimmunity and end-organ damage

Environmental Aspects of Pathogenesis

Drug-induced lupus mechanisms

Gender and age in lupus

Roles for infections in systemic lupus erythematosus pathogenesis

Systemic lupus erythematosus in domestic animals

Mechanisms of Tissue Injury

Pathogenesis of lupus nephritis

Tissue injury and the skin

Neuropsychiatric systemic lupus erythematosus: Mechanisms of injury

Atherosclerosis and tissue injury in systemic lupus erythematosus

Clinical Aspects of Disease

Clinical Presentation

The clinical presentation of systemic lupus erythematosus

Neonatal lupus

SLE in children

Drug-induced disease

Laboratory evaluation of patients with systemic lupus erythematosus

Pregnancy and reproductive concerns in systemic lupus erythematosus

Epidemiology of systemic lupus erythematosus

Monitoring disease activity

Incomplete lupus erythematosus

Design of clinical trials for SLE

Organ Systems

The nervous system and lupus

Skin

Kidney

Heart

Vasculitis

Lung

Gastrointestinal: Liver

Gastrointestinal: Nonhepatic

Cellular hematology

Musculoskeletal system: Articular disease, bone metabolism

Anti-Phospholipid Syndrome

Pathogenesis

Antiphospholipid antibody: Pathogenesis

Endothelial cell damage and atherosclerosis

Clinical

Laboratory testing for antiphospholipid syndrome

Clinical presentation of antiphospholipid syndrome

Pregnancy and antiphospholipid syndrome

Treatment of antiphospholipid syndrome

Treatment

Steroids and nonsteroidal anti-inflammatory drugs

Antimalarials

Cytotoxic agents

Biological agents

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