Systems Biology

by Nakanishi, Shigetada; Kageyama, Ryoichiro; Watanabe, Daisuke

• ISBN13: 9784431877035
• ISBN10: 4431877037
• Format: Hardcover
• Copyright: 2009-09-30
• Publisher: Springer Verlag

Summary

Biological signaling pathways dynamically interact with one another to form complex information networks intracellularly, intercellularly, and eventually at the level of the organism. Biology and medicine have conventionally focused on identification and characterization of functional elements in biological signaling pathways. Recently, research in this field has pursued a new approach, systems biology, to understand the dynamics, complexity, and physiological functions of the biological signaling networks. Instead of reductionistic analyses or large-scale studies of biomolecules piece by piece, systems biology emphasizes the need for interdisciplinary methods and analysis of the regulation and operation of information networks at the systems level. The contributors to this book are leading researchers in the rising field of systems biology. Readers will find not only the most recent advances in research, but also the latest information about interdisciplinary methods and related topics.

Table of Contents

Preface	p. v
Contributors	p. xi
Dynamics and Complexity of Intercellular Networks
Integrative Synaptic Mechanisms of the Neural Network	p. 3
The Molecular and Cellular Design of Networks in Motion	p. 11
Bacterial Complexity: More Is Different on All Levels	p. 25
How Animals Get Their Skin Patterns: Fish Pigment Pattern as a Live Turing Wave	p. 37
Characterization and Application of Natural Light-Sensitive Proteins	p. 47
Systems Biology of Mammalian Circadian Clocks	p. 57
Toward Understanding How the Immune System Establishes a Diverse Yet Self-Tolerant T-Cell Repertoire: Stepwise Roles of Thymic Microenvironments	p. 71
The Mechanisms of Motor Programming for Learned Vocalization in Songbirds	p. 83
Dynamic Model of the Basal Ganglia Functions and Movement Disorders	p. 91
Integrative Mechanism of Intracellular Information Networks
A Posttranslational Chemical Circadian Oscillator in Cyanobacteria	p. 101
The Apoptotic Signaling Network Dynamically Interprets the Outputs of Individual Signaling Pathways in an Early Analog and Late Digital Manner	p. 111
Specific Features of Transient Ras and Sustained Rap1 Activation	p. 121
Control and Alteration of Protein Traffic in the Cell	p. 129
Plant Functional Genomics Based on Integration of Metabolomics and Transcriptomics: Toward Plant Systems Biology	p. 135
A Possible Role of Homeostasis Between Monomeric and Filamentous Actin in Filament Nucleation Revealed by Pharmacokinetic Modeling	p. 143
Molecules, Networks, and Memory	p. 151
Systems Biology Meets Single-Cell Physiology: Role of a Positive-Feedback Signal Transduction Network in Cerebellar Long-Term Synaptic Depression	p. 159
Computational Models of Cerebellar Long-Term Memory	p. 169
Biogenesis and Function Mechanisms of Micro-RNAs and Their Role as Oncogenes and Tumor Suppressors	p. 183
Dysfunction of Information Networks and Related Diseases
The Pathogenetic Significance of Deregulated Transcription Factors in Hematological Malignancies	p. 193
Ultradian Oscillation Networks in Somite Segmentation and Other Biological Events	p. 199
The Cellular Basis of Dictyostelium Morphogenesis	p. 209
Metabolic Information Highway: Interorgan Metabolic Communication Via the Autonomic Nervous System	p. 221
Involvement of the CCR4-NOT Deadenylase Complex in the Control of Cell Growth	p. 229
Reconstruction of Nuclear Reprogramming by Defined Factors	p. 239
Index	p. 243
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