9784431877035

Systems Biology

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  • ISBN13:

    9784431877035

  • ISBN10:

    4431877037

  • Format: Hardcover
  • Copyright: 2009-09-30
  • Publisher: Springer Verlag
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List Price: $249.99

Summary

Biological signaling pathways dynamically interact with one another to form complex information networks intracellularly, intercellularly, and eventually at the level of the organism. Biology and medicine have conventionally focused on identification and characterization of functional elements in biological signaling pathways. Recently, research in this field has pursued a new approach, systems biology, to understand the dynamics, complexity, and physiological functions of the biological signaling networks. Instead of reductionistic analyses or large-scale studies of biomolecules piece by piece, systems biology emphasizes the need for interdisciplinary methods and analysis of the regulation and operation of information networks at the systems level. The contributors to this book are leading researchers in the rising field of systems biology. Readers will find not only the most recent advances in research, but also the latest information about interdisciplinary methods and related topics.

Table of Contents

Prefacep. v
Contributorsp. xi
Dynamics and Complexity of Intercellular Networks
Integrative Synaptic Mechanisms of the Neural Networkp. 3
The Molecular and Cellular Design of Networks in Motionp. 11
Bacterial Complexity: More Is Different on All Levelsp. 25
How Animals Get Their Skin Patterns: Fish Pigment Pattern as a Live Turing Wavep. 37
Characterization and Application of Natural Light-Sensitive Proteinsp. 47
Systems Biology of Mammalian Circadian Clocksp. 57
Toward Understanding How the Immune System Establishes a Diverse Yet Self-Tolerant T-Cell Repertoire: Stepwise Roles of Thymic Microenvironmentsp. 71
The Mechanisms of Motor Programming for Learned Vocalization in Songbirdsp. 83
Dynamic Model of the Basal Ganglia Functions and Movement Disordersp. 91
Integrative Mechanism of Intracellular Information Networks
A Posttranslational Chemical Circadian Oscillator in Cyanobacteriap. 101
The Apoptotic Signaling Network Dynamically Interprets the Outputs of Individual Signaling Pathways in an Early Analog and Late Digital Mannerp. 111
Specific Features of Transient Ras and Sustained Rap1 Activationp. 121
Control and Alteration of Protein Traffic in the Cellp. 129
Plant Functional Genomics Based on Integration of Metabolomics and Transcriptomics: Toward Plant Systems Biologyp. 135
A Possible Role of Homeostasis Between Monomeric and Filamentous Actin in Filament Nucleation Revealed by Pharmacokinetic Modelingp. 143
Molecules, Networks, and Memoryp. 151
Systems Biology Meets Single-Cell Physiology: Role of a Positive-Feedback Signal Transduction Network in Cerebellar Long-Term Synaptic Depressionp. 159
Computational Models of Cerebellar Long-Term Memoryp. 169
Biogenesis and Function Mechanisms of Micro-RNAs and Their Role as Oncogenes and Tumor Suppressorsp. 183
Dysfunction of Information Networks and Related Diseases
The Pathogenetic Significance of Deregulated Transcription Factors in Hematological Malignanciesp. 193
Ultradian Oscillation Networks in Somite Segmentation and Other Biological Eventsp. 199
The Cellular Basis of Dictyostelium Morphogenesisp. 209
Metabolic Information Highway: Interorgan Metabolic Communication Via the Autonomic Nervous Systemp. 221
Involvement of the CCR4-NOT Deadenylase Complex in the Control of Cell Growthp. 229
Reconstruction of Nuclear Reprogramming by Defined Factorsp. 239
Indexp. 243
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