Systems Biology : A Textbook

by Klipp, Edda; Liebermeister, Wolfram; Wierling, Christoph; Kowald, Axel; Lehrach, Hans; Herwig, Ralf

• ISBN13: 9783527318742
• ISBN10: 3527318747
• Edition: 1st
• Format: Paperback
• Copyright: 2009-08-03
• Publisher: Wiley-Blackwell

Summary

Systems biology is a highly topical discipline at the intersection of biochemistry, cell biology, computer science, and systems engineering.This coursebook in systems biology is tailored to the needs of advanced students of biology, engineering, and computer science. It has a companion website with solutions to questions in the book, additional chapters, and computer implementations of systems biology models.The book is a follow-up of the very successful Systems Biology in Practice and incorporates the feedback and suggestions of many lecturers worldwide.The interdisciplinary team of acclaimed authors have worked closely together to ensure a comprehensive coverage of the topic in a fluent and compelling style.Further material is available on www.wiley-vch.de/home/systemsbiologySystems Biology in Practice - Praise from the reviews:"...this is one book that I bought for myself as soon as it was published." -British Journal of Occupational Therapy"This resource does an admirable job of bringing the readers to a level where they can pursue more advanced study and research." -IEEE Engineering in Medicine and Biology Magazine"... I am confident that biologists everywhere will benefit from having a copy to hand." -Theoretical Biology and Medical Modelling

Author Biography

Edda Klipp (born 1965) studied theoretical biophysics at the Humboldt University Berlin. A member of the Yeast Systems Biology Network, her research interests include mathematical modeling of cellular systems, signal transduction, systems biology, and text mining.

Wolfram Liebermeister (born 1972) studied physics in T++bingen and Hamburg and obtained a PhD of theoretical biophysics at the Humboldt University of Berlin. In his works on complex biological systems, he points out functional aspects like variability, information, and optimality.

Christoph Wierling (born 1973) studied biology at the University of M++nster and recently obtained a PhD degree on the modeling and simulation of biological systems.

Axel Kowald (born 1963) holds a PhD in mathematical biology from the National Institute for Medical Research, London. His current research interests focus on the mathematical modeling of processes involved in the biology of aging and systems biology.

Hans Lehrach (born 1946) is a director at the Max Planck Institute for Molecular Genetics in Berlin and was spokesman for the German Human Genome Initiative. His research interests focus on functional genomics, technology development and systems biology.

Ralf Herwig (born 1967) studied mathematics and physics at the Free University Berlin and completed a PhD on statistical clustering methods. He has specialized in integrative bioinformatics projects covering genomics, proteomics and systems biology.

Table of Contents

Introduction to Systems Biology

Introduction Modeling of Biochemical Systems Specific Biochemical Systems

Model Fitting Analysis of High-throughput Data Gene Expression

Models Stochastic Systems and Variability Network Structures, Dynamics, and Function Optimality and Evolution

Biological and Mathematical Fundamentals and Methods

Cell Biology Experimental Techniques in Molecular Biology Mathematics Statistics Stochastic Processes

Linear Control Systems Databases Modeling Tools

Table of Contents provided by Publisher. All Rights Reserved.