This book applies systems biology methods to analyze Traditional Chinese Medicine (TCM), providing a comprehensive resource for modernization of TCM research and drug discovery. Using three popular Chinese medicines - Shuanglongfang, Qingkailing, and Liushenwan - as examples, the author illustrates how to find material groups, perform efficacy screening, and conduct safety evaluations of TCM. In addition, the coverage describes TCM in terms of chemomics, genomics, proteomics, and metabolomics. By putting modern scientific technologies in the context of TCM, this resource helps scientists and TCM practitioners improve experimental designs and strategies, and better communicate.

Guoan Luo is Professor in the Institute of Biomedicine and Director of the Modern Research Center for Traditional Chinese Medicine at Tsinghua University in Beijing. Professor Luo is dedicated to the application of systems biology to study and advance TCM. He has published more than 680 peer-reviewed papers and applied for thirty-one patents. Among the many honors he has received for his research achievements are two National Scientific and Technological Advancement Prizes. Yiming Wang is Professor at Tsinghua University. Qionglin Liang is Associate Professor at Tsinghua University. Qingfei Liu is Assistant Professor at Tsinghua University

Foreword	p. ix
Preface	p. xiii
Abbreviations	p. xvii
Introduction of Systems Biology in Traditional Chinese Medicine (TCM)	p. 1
Characteristics and Compatibility Principles of Traditional Chinese Medicine (TCM)	p. 1
Key Scientific Issues in TCM Modernization	p. 9
Development of Systems Biology	p. 16
Chemomics Integrated Systems Biology	p. 19
Research Strategy and Prospective of Systems Biology in TCM	p. 25
References	p. 34
Chemomics of Traditional Chinese Medicine	p. 38
Characteristics and Research Difficulties in TCM	p. 39
Background of TCM Chemomics' Proposal and Development	p. 45
Chemomics	p. 52
Chemomics and the Research of Formulas	p. 58
References	p. 63
Technological Platform of TCM Chemomics	p. 66
Acquisition Methods and Techniques for TCM Chemomics	p. 66
Characterization Techniques of Chemome-TCM Fingerprinting	p. 73
Information Processing for the Study of TCM Chemomics	p. 107
Development of an Intelligent Quality Control System in the Process of Chinese Medicine Production	p. 119
References	p. 127
Pharmacokinetic Investigation on TCM Formulas Based on Global Systems Biology	p. 131
Pharmacokinetic Characteristics of TCM Formulas	p. 131
Methodology of Pharmacokinetics of TCM Formulas	p. 133
Application of PK-PD Model in the Toxicological Research of Liushen Pills (LSP)	p. 138
Prospect	p. 143
References	p. 144
Application Of Genomics in the Research Of TCM	p. 146
Genomics and TCM System Research	p. 146
Prospect of Genomics in TCM Research	p. 148
Cases of the Application of Genomics in TCM Research	p. 148
References	p. 168
Proteomics Study of TCM	p. 171
Proteomics in TCM Research	p. 171
A Case Study of Proteomics in TCM	p. 174
The Application of High Content Screening in TCM Research	p. 182
Limitations and Prospect of TCM Proteomics	p. 186
References	p. 187
Application of Metabonomics in Research on TCM	p. 191
Current Research Situation of Metabonomics	p. 191
Integration of Quantitative Metabonomics Platform Technology (QMPT)	p. 191
Application of Metabonomics in the Field of Medicine	p. 194
Examples of Metabonomic Research on TCM	p. 198
References	p. 206
Application of Chemometrics and Bioinformatics in TCM Research	p. 210
Introduction of Chemometrics	p. 210
Chemometric Techniques and Their Applications in TCM Research	p. 211
Introduction of Bioinformatics	p. 216
Bioinformatics Techniques and Their Applications in the Research of TCM	p. 219
Conclusions	p. 222
References	p. 224
Study of Integrated Biomarker System of Diabetic Nephropathy	p. 228
Introduction of Diabetic Nephropathy	p. 228
Mogensen Staging and TCM Typing of DN	p. 234
The Metabonomics Study of DN	p. 244
Condition of Metabolism after Treatment with TangShen Formula (TSF)	p. 278
Genomics Study of Diabetic Neuropathy	p. 286
The Integrated Biomarker System of DN	p. 301
Conclusions	p. 311
References	p. 312
Chemomics Research on the TCM Formula of the Qingkailing Injection	p. 317
Chemomics Research of Qingkailing Injection	p. 318
Pharmacodynamic Evaluation of Qingkailing Injection	p. 330
Research on the Qingkailing Derived Formula	p. 335
Conclusions	p. 368
References	p. 369
Integrated Global Systems Biology for the Research and Development of Chinese Medicine Shuanglong Formula	p. 371
Brief Introduction to the Shuanglong Formula	p. 371
Chemomics Study of the Shuanglong Formula	p. 374
Pharmacodynamic Evaluation of SLF Effective Ingredients	p. 384
Systems Biology Study of the Mechanism of Directed Differentiation of Stem Cells Induced by NSLF6	p. 402
Anti-Myocardial Infarction Effect of NSLF6	p. 426
Conclusions	p. 429
References	p. 430
Demonstrative Research on the Safety Evaluation of Liushen Pills	p. 437
Introduction	p. 437
Toxicity Study of Chansu	p. 438
Chemomics Study of LSP	p. 446
Assessment of Effectiveness and Safety of LSP	p. 457
In Vivo Distribution and Metabonomics of LSP and Xionghuang	p. 462
Metabonomic Research of LSP	p. 467
Conclusions	p. 477
References	p. 478
Index	p. 481
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