Tamoxifen and Breast Cancer

by Degregorio, Michael W.; Wiebe, Valerie J.

• ISBN13: 9780300059076
• ISBN10: 0300059078
• Format: Hardcover
• Copyright: 1994-04-01
• Publisher: Yale Univ Pr

Summary

Tamoxifen is one of the most widely prescribed drugs used to prevent the recurrence of breast cancer. A nonsteroidal antiestrogen, it has been successful in treating postmenopausal women at nearly all stages of breast cancer. Despite its popularity, disturbing questions remain about the use of this drug. How effective is tamoxifen in treating patients who have hormone-insensitive breast tumors or who have not yet reached menopause? What are the potential risks in taking tamoxifen, and do they ever outweigh its benefits? Should tamoxifen be administered as a prophylactic drug for healthy premenopausal women who are at high risk of developing breast cancer? In this vitally important book, two leading scientific investigators present a balanced and accessible discussion of the diagnosis of breast cancer and the risks, benefits, and limitations of treatment alternatives, particularly tamoxifen. Michael W. DeGregorio and Valerie J. Wiebe discuss the history and evolution of tamoxifen as a treatment for breast cancer, explaining how it works, what its side effects are, and why tamoxifen treatment is unsuccessful for some women. They present the controversies surrounding the National Cancer Institute study of tamoxifen as a preventive for breast cancer, describing the hopes of the proponents of the study and the fears of its detractors (potential risks to women in the study include thrombosis, uterine cancer, and even breast cancer itself). The book is an invaluable aid to women faced with decisions about treatment or prevention of breast cancer.

Table of Contents

Preface	ix
Common Questions about Breast Cancer	1	(13)
Drug Therapy	14	(13)
Tamoxifen and How It Works	27	(6)
Tamoxifen in Breast Cancer	33	(12)
Side Effects of Tamoxifen	45	(7)
Tumor Recurrence and Tamoxifen Resistance	52	(9)
Tamoxifen for Prevention in Healthy Women	61	(11)
The Ongoing Controversy over the Tamoxifen Chemoprevention Trial	72	(12)
Future Approaches	84	(7)
Afterword	91	(4)
Recent Developments	95	(6)
Glossary	101	(4)
References	105	(10)
Index	115