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9780415248389

Target Organ Toxicity in Marine and Freshwater Teleosts: Organs

by ;
  • ISBN13:

    9780415248389

  • ISBN10:

    0415248388

  • Format: Hardcover
  • Copyright: 2001-04-12
  • Publisher: CRC Press

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Summary

Addressing the numerous gaps in current information, Target Organ Toxicology in Marine and Freshwater Teleosts is an essential resource for researchers and professionals in aquatic toxicology and environmental risk assessment.All the chapters are written by researchers who are internationally recognised for their work in mechanistic aspects of aquatic toxicology. Each chapter focuses on a specific target organ or physiological system and describes how various agents disrupt the normal physiological system and processes. This volume is devoted to specific organs with coverage of the gill, kidney, skin, liver and gut. The companion volume, Systems, provides coverage of toxic effects in the central nervous, immune, neurobehavioural and reproductive systems as well as describing general mechanisms of toxicity.

Table of Contents

List of contributors
vii
Foreword viii
Copyright acknowledgments ix
Toxic responses of the gill
1(89)
Chris M. Wood
Introduction
1(1)
Functional anatomy
1(12)
Basic physiology
13(9)
General responses to toxicants
22(9)
Specific responses to selected toxicants
31(33)
Concluding remarks
64(26)
Target organ toxicity in the kidney
90(61)
Bodil K. Larsen
Everett J. Perkins
Introduction
90(1)
Functional morphology of the teleost kidney
91(7)
Overall kidney function
98(2)
Urine formation
100(17)
Control of kidney function
117(7)
Concluding remarks on teleost kidney physiology
124(2)
Nephrotoxicity
126(13)
Concluding remarks on nephrotoxicity
139(12)
Toxic responses of the skin
151(73)
James M. Mckim
Gregory J. Lien
Introduction
151(2)
Structure--function of fish skin
153(13)
Skin absorption of xenobiotics
166(16)
Toxic responses of the skin
182(9)
Research needs
191(33)
Toxic responses of the liver
224(45)
David E. Hinton
Helmut Segner
Thomas Braunbeck
Introduction
224(1)
Important aspects of fish liver anatomy related to interpretation of toxicity
225(6)
Important aspects of fish liver physiology related to interpretation of toxicity
231(5)
Studies with reference hepatotoxicants in fish
236(5)
Hepatocellular adapation
241(2)
Hepatobiliary system
243(4)
In vitro model systems
247(4)
Chronic toxicity -- liver carcinogenesis studies
251(3)
Information gaps and future directions
254(15)
Response of the teleost gastrointestinal system to xenobiotics
269(94)
Kevin M. Kleinow
Margaret O. James
Introduction
269(1)
Structure of the gastrointestinal tract
270(11)
Gastrointestinal tract physiology
281(9)
Xenobiotic absorption and disposition
290(25)
Elimination
315(2)
Gastrointestinal tract toxicity
317(22)
Summary
339(24)
Index 363

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