Targeting of Drugs 6

by Gregoriadis, Gregory; North Atlantic Treaty Organization. Scientific Affairs Division

• ISBN13: 9780306459375
• ISBN10: 030645937X
• Format: Hardcover
• Copyright: 1998-11-01
• Publisher: Plenum Pub Corp

Summary

Univ. of London, UK. Proceedings of a NATO Advanced Study Institute on Targeting of Drugs: Strategies for Stealth Therapeutic Systems, held June 24-July 5, 1997, at Cape Sounion Beach, Greece. DNLM: Drug Carriers congresses.

Table of Contents

Interactions between Blood Components and Artificial Surfaces	1	(14)
K.D. Caldwell
The Mononuclear Phagocyte System: Features Relevant to Interactions with Liposomes	15	(10)
S. Gordon
Stealth(TM) Therapeutic Systems: Rationale and Strategies	25	(10)
D.J.A. Crommelin
G. Storm
Long Circulating Liposomes: Evolution of the Concept	35	(6)
G. Gregoriadis
Sterically Stabilized Immunoliposomes: Formulations for Delivery of Drugs and Genes to Tumor Cells in Vivo.	41	(8)
J.W. Park
D. Kirpotin
K. Hong
W. Zheng
Y. Shao
O. Meyer
C.C. Benz
D. Papahadjopoulos
Pegylation of Liposomes in Cell-Specific Targeting: It Does Not Always Make Sense	49	(12)
G.L. Scherphof
G.A. Koning
J.A.A.M. Kamps
T. Daemen
Stealth(TM) Liposomes for the Targeting of Drugs in Cancer Therapy	61	(16)
T.M. Allen
D. Lopes de Menezes
C.B. Hansen
E.H. Moase
Stealth(TM) Liposomes as Carriers of Doxorubicin	77	(10)
D. Goren
S. Zalipsky
A. Horowitz
A. Gabizon
Liposome-Mediated Delivery of Retinoids	87	(8)
K. Mehta
E. Estey
G. Lopez-Berestein
Applications of Liposome Technology to Overcome Multidrug Resistance in Solid Tumors	95	(14)
R. Krishna
L.D. Mayer
Use of Radiolabeled Liposomes for PEG-Liposome-Based Drug Targeting and Diagnostic Imaging Applications	109	(12)
W.T. Phillips
Diagnostic and Therapeutic Targeting of Infectious and Inflammatory Diseases Using Sterically Stabilized Liposomes	121	(10)
G. Storm
I.A.J.M. Bakker-Woundenberg
R.M. Schiffelers
W.J.G. Oyen
D.J.A. Crommelin
F.H.M. Corstens
O.C. Boerman
Biologically Active Ligand-Bearing Polymer-Grafted Liposomes	131	(8)
S. Zalipsky
J. Gittelman
N. Mullah
M.M. Qazen
J. Harding
Engineering Stealth(TM) Liposome Surfaces: Exercises in Colloid Chemistry Principles	139	(8)
K. Kostarelos
The Role of Hydration in Stabilization of Liposomes: Resistance to Oxidative Damage of PEG-Grafted Liposomes	147	(22)
A. Priev
A.M. Samuni
O. Tirosh
Y. Barenholz
Physicochemical Characterization of DOTAP-Containing Lipoplexes by Fluorescent Probes: Relevance to Lipofection	169	(16)
D. Hirsch-Lerner
N.J. Zuidam
Y. Barenholz
Steric Stabilization of Cationic Liposome-DNA Complexes: Influence on Morphology and Transfection Activity	185	(8)
B. Sternberg
K. Hong
W. Zheng
D. Papahadjopoulos
Polysialic Acids: Potential for Long Circulating Drug, Protein, Liposome and Other Microparticle Constructs	193	(14)
G. Gregoriadis
A. Fernandes
B. McCormack
M. Mital
X. Zhang
Tailor-Made Solubel Polymer Carriers	207	(18)
P. Ferruti
R. Duncan
S. Richardson
Development of Novel Technologies for the Synthesis of Biodegradable Pegylated Nanoparticles	225	(16)
M.T. Peracchia
D. Desmaele
C. Vauthier
D. Labarre
E. Fattal
J. d'Angelo
P. Couvreur
Development of a New Class of Nanoparticles which Avoid Phagocytosis by Inhibiting Complement Activation	241	(12)
C. Passirani
G. Barratt
J.-P. Devissaguet
D. Labarre
Coating of Nanoparticles with Surfactants: Targeting versus Prolonged Circulation	253	(10)
J. Kreuter
Recent Developments and Limitations of Poloxamine-Coated Long-Circulating Particles in Experimental Drug Delivery	263	(12)
S.M. Moghimi
PEG-Coated Nanospheres: Surface Optimization and Therapeutic Applications	275	(12)
R. Gref
P. Quellec
M.J. Alonso
M. Tobio
M. Luck
R.H. Muller
E. Dellacherie
Participants' Photograph	287	(2)
Contributors	289	(6)
Index	295