Taxane Anticancer Agents Basic Science and Current Status

by Georg, Gunda I.; Chen, Thomas T.; Ojima, Iwao; Vyas, Dolatrai M.

• ISBN13: 9780841230736
• ISBN10: 0841230730
• Format: Hardcover
• Copyright: 1995-05-05
• Publisher: American Chemical Society

Summary

Presents an overview of the development of paclitaxel as an anticancer drug, including the discovery, initial development, current status, supply issues, and recent clinical developments. Discusses in detail the cellular mechanism of action and the toxicity of paclitaxel. Presents drug delivery and taxotere metabolism. Explains semisynthetic and medicinal chemistry studies. Covers approaches to the total synthesis of paclitaxel.

Table of Contents

Overview of Paclitaxel Research: Progress on Many Fronts

Paclitaxel: From Discovery to Clinic

Current Status of Clinical Trials with Paclitaxel and Docetaxel

The Pacific Yew Environmental Impact Statement

Paclitaxel Biosynthesis: The Early Steps

Bioactive Metabolites of the Endophytic Fungi of Pacific Yew, Taxus brevifolia: Paclitaxel, Taxanes, and Other Bioactive Compounds

Metabolism of Taxoid Drugs

Pharmacology and Antitumor Effect of Novel Paclitaxel Formulations

Phosphatase-Activated Prodrugs of Paclitaxel

Microtubule Polymerization Dynamics, Mitotic Block, and Cell Death by Paclitaxel at Low Concentrations

Photoincorporation of a Paclitaxel Photoaffinity Analogue into the N-Terminal 31 Amino Acids of b-Tubulin

Paclitaxel, a Mimetic of Bacterial Lipopolysaccharide (LPS) in Murine Macrophages

The Roles of the Cytoskeleton in Steroidogenesis: The Actions of Paclitaxel and Other Cytoskeletal Agents

Chemistry and Structure-Activity Relationships of Taxoids with Modified Skeletons

Recent Advances in the Chemistry and Structure-Activity Relationships of Paclitaxel

Medicinal Chemistry of Paclitaxel: Chemistry, Structure-Activity Relationships, and Conformational Analysis

Practical Semisynthesis and Antimitotic Activity of Docetaxel and Side-Chain Analogues

Paclitaxel Structure-Activity Relationships and Core Skeletal Rearrangements

Syntheses and Structure-Activity Relationships of New Taxoids

Chemistry and Antitumor Activity of 9(R)-Dihydrotaxanes

The Total Synthesis of Paclitaxel Starting with Camphor

The Total Synthesis of Paclitaxel by Assembly of the Ring System

Toward the Design of a Convergent Practical Route to All Classes of Taxanes

The Pinene Path to Taxanes: Genesis and Evolution of a Strategy for Synthesis

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