Taxol: Science and Applications

by Suffness; Matthew

• ISBN13: 9780849383823
• ISBN10: 084938382X
• eBook ISBN(s): 9780429612428
• Format: Hardcover
• Copyright: 1995-05-25
• Publisher: CRC Press

Summary

This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.

Table of Contents

Introduction

Discovery and Development of TAXOL«, M. Suffness and M.E. Wall

Yew and Us: A Brief History of the Yew Tree. H.R. Hartzell, Jr.

Supply of TAXOL«

Taxus for TAXOL« and Taxoids, E.M. Croom, Jr.

Potential of Plant Cell Culture for Taxane Production, D.M. Gibson, R.E.B. Ketchum, T.J. Hirasuna, and M.L. Shuler

Semisynthesis of TAXOL« and Taxotere, R.A. Holton, R.J. Biediger, and P. Douglas Boatman

Toward the Total Synthesis of TAXOL« and Its Analogues, P.A. Wender, M.G. Natchus, and A.J. Shuker

Biology of TAXOL«

Biosynthesis of TAXOL«, H.G. Floss and U. Mocek

Preclinical Antitumor Activity of Taxanes, W.C. Rose

Biopharmaceutics of Paclitaxel (TAXOL«): Formulation, Activity, and Pharmacokinetics, R.M. Straubinger

The Use of TAXOL« in Cell Biology, R.B. Vallee

Chemistry of TAXOL«

Detection and Isolation, K.M. Snader

Natural Taxoids: Structure and Chemistry, D.G.I. Kingston

The Medicinal Chemistry of TAXOL« , G.I. Georg, T.C. Boge, Z.S. Cheruvallath, J.S. Clowers, G.C.B. Harriman, M. Hepperie, and H. Park

Clinical Studies

TAXOL« : Clinical Results and Current Issues in Development, S.G. Arbuck and B.A. Blaylock

Index