Telomeres

by De Lange, Titia; Lundblad, Vicki; Blackburn, Elizabeth

• ISBN13: 9780879697341
• ISBN10: 0879697342
• Edition: 2nd
• Format: Hardcover
• Copyright: 2005-11-16
• Publisher: Cold Spring Harbor Laboratory Press

Summary

An up-to-date survey of the current exciting state of telomere biology. Telomeres #x13; specialized structures found at the ends of chromosomes #x13; are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

Table of Contents

Preface	vii
A History of Telomere Biology	1	(20)
E.H. Blackburn
The Telomerase Ribonucleoprotein Particle	21	(28)
G. Cristofari
J. Lingner
Telomerase Biochemistry and Biogenesis	49	(32)
J.-L. Chen
C.W. Greider
Telomerase and Human Cancer	81	(28)
J.W. Shay
W.E. Wright
Modeling Cancer and Aging in the Telomerase-deficient Mouse	109	(30)
K.-K. Wong
S. Chang
R.A. DePinho
Telomerase Deficiency and Human Disease	139	(24)
I. Dokal
T. Vulliamy
Telomerase-independent Maintenance of Mammalian Telomeres	163	(36)
A.A. Neumann
R.R. Reddel
Telomerase-independent Telomere Maintenance in Yeast	199	(26)
M.J. McEachern
J.E. Haber
Meiotic Telomeres	225	(36)
H. Scherthan
Telomere Position Effect: Silencing Near the End	261	(56)
M.A. Mondoux
V.A. Zakian
The Structural Biology of Telomeres	317	(28)
D. Rhodes
Budding Yeast Telomeres	345	(42)
V. Lundblad
Mammalian Telomeres	387	(46)
T. de Lange
Drosophila Telomeres	433	(32)
S. Pimpinelli
Ciliate Telomeres	465	(30)
C. Price
Fission Yeast Telomeres	495	(30)
J.P. Cooper
Y. Hiraoka
Plant Telomeres	525	(26)
D.E. Shippen
Appendix: A Personal Account of the Discovery of Telomerase	551	(14)
E.H. Blackburn
Index	565