Testicular Cell Dynamics and Endocrine Signaling, Volume 1061

by Hardy, Matthew P.; Griswold, Michael

• ISBN13: 9781573315388
• ISBN10: 1573315389
• Edition: 1st
• Format: Paperback
• Copyright: 2006-01-24
• Publisher: Wiley-Blackwell

Summary

The past few years have brought an influx of new information into the field of male reproduction. Several laboratories have been able to apply the genomics approach to gene expression in the male, revealing previously unknown patterns of gene expression and gene products that were localized in male reproductive tract tissues and cells for the first time. These discoveries paved the way for the next wave, an opportunity to analyze male reproductive biology and the processes by which sperm are formed in the seminiferous tubule and androgen is synthesized in the interstitium of the testis.The different levels of organization in the testis, including the stages of spermatogenesis, enzymatic steps of steroidogenesis, and the intracellular signaling pathways of hormones, are now more amenable to study and selection of potential targets for drug development. This volume capitalizes on these developments with a collection of reports that is uniquely suited to stimulate research and development ideas.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Matthew P. Hardy and Michael Griswold are the authors of Testicular Cell Dynamics and Endocrine Signaling, Volume 1061, published by Wiley.

Table of Contents

Preface

Development

Hormonal Regulation of Male Reproductive Tract Development

Sox9 in Testis Determination

Seminiferous Cord Formation and Germ-Cell Programming

In Vitro Generation of Germ Cells: New Techniques to Solve Current Issues

The Endocrine Axis

Structure-Function Relationships of the Luteinizing Hormone Receptor

Transgenic Rescue of SF-1-Null Mice

Estrogens in Testis Biology

Foxa1 and Foxa2 Interact with the Androgen Receptor to Regulate Prostate and Epididymal Genes Differentially

Role of Glial Cell Line-Derived Neurotrophic Factor in Germ-Line Stem Cell Fate

Steroidogenesis

P450 Oxidoreductase Deficiency: A New Disorder of Steroidogenesis

Neuroendocrine Regulation of Leydig Cell Development

Mitochondrial Function in Leydig Cell Steroidogenesis

Determining Structure and Function of Steroid Dehydrogenase Enzymes by Sequence Analysis, Homology Modeling, and Rational Mutational Analysis

Spermatogenesis

Postnatal and Pubertal Development of the Rhesus Monkey (Macaca mulatta) Testis

The mRNA Encoding CstF-64 Is Expressed Ubiquitously in Mouse Tissues

Drivers of Germ Cell Maturation

Role of Nuclear Receptors in INSL3 Gene Transcription in Leydig Cells

Analysis of the Human Sperm Proteome

Clinical Correlates

Male Gamete Contributions to the Embryo

The Androgen Microenvironment of the Human Testis and Hormonal Control of Spermatogenesis

Sperm Chemotaxis: A Primer

Epigenetic Regulation of Testis-Specific Gene Expression

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