Testicular Chromosome Structure and Gene Expression, Volume 1120

by Eddy, E. Mitchell; Griswold, Michael D.

• ISBN13: 9781573316934
• ISBN10: 1573316938
• Edition: 1st
• Format: Paperback
• Copyright: 2008-01-14
• Publisher: Wiley-Blackwell

Summary

The 2005 Workshop, published as volume 1061 of the Annals, focused on testicular cell dynamics and brought an influx of new information into the field of male reproduction. Several laboratories have been actively investigating the endocrine signals between the germ and somatic cells of the testis, revealing previously unknown patterns of cell signaling and cell-to-cell communication in male reproductive tract tissues. Work in this area will provide an opportunity to analyze male reproductive biology and the processes by which sperm are formed in the seminiferous tubule and androgen is synthesized in the interstitium of the testis.The different levels of organization in the testis, including the stages of spermatogenesis, enzymatic steps of steroidogenesis and the intracellular signaling pathways of hormones, are now more amenable for study and selection of potential targets for drug development. Capitalizing on these developments, the editors of this volume have chosen a roster of chapter contributors that is uniquely suited to stimulate research and development ideas among readers.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

E. Mitchell Eddy is the author of Testicular Chromosome Structure and Gene Expression, Volume 1120, published by Wiley.

Table of Contents

Overview: Testicular Chromosome Structure and Gene Expression	p. xi
Genomics and Expression Profiling
Toward Understanding the Core Meiotic Transcriptome in Mammals and Its Implications for Somatic Cancer	p. 1
Gene Expression During Development of Fetal and Adult Leydig Cells	p. 16
Identification of Testis-Specific Male Contraceptive Targets: Insights from Transcriptional Profiling of the Cycle of the Rat Seminiferous Epithelium and Purified Testicular Cells	p. 36
Stem Cells and Spermatogonia
Stem Cell Heterogeneity: Actual and Potential Stem Cell Compartments in Mouse Spermatogenesis	p. 47
Culture and Genetic Modification of Mouse Germline Stem Cells	p. 59
Regulation of Gene Expression
Regulation and Function of the Rhox5 Homeobox Gene	p. 72
Noncoding RNAs of the Mammalian Testis: The Meiotic Transcripts Nct1 and Nct2 Encode piRNAs	p. 84
Role of an Insulator in Testis-specific Gene Transcription	p. 95
Somatic Cells of the Testis
Sox8 and Sertoli-cell Function	p. 104
Potential Functions of Retinoic Acid Receptor A in Sertoli Cells and Germ Cells During Spermatogenesis	p. 114
Role of Connexin 43 in Sertoli Cells of Testis	p. 131
ETV5 Is Required for Continuous Spermatogenesis in Adult Mice and May Mediate Blood-Testes Barrier Function and Testicular Immune Privilege	p. 144
Testicular Morphogenesis: Comparison of In Vivo and In Vitro Models to Study Male Gonadal Development	p. 152
Clinical Correlates
From Gonocytes to Testicular Cancer: The Role of Impaired Gonadal Development	p. 168
The Role of dead-end in Germ-cell Tumor Development	p. 181
Chromosomes and Expression in Human Testicular Germ-Cell Tumors: Insight into Their Cell of Origin and Pathogenesis	p. 187
Index of Contributors	p. 215
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