Testosterone: Action, Deficiency, Substitution

by Edited by E. Nieschlag , H. M. Behre , Assisted by S. Nieschlag

• ISBN13: 9780521833806
• ISBN10: 0521833809
• Edition: 3rd
• Format: Hardcover
• Copyright: 2004-05-10
• Publisher: Cambridge University Press

Summary

This book provides the most comprehensive and up-to-date source of information on testosterone and other androgens, and their role in human physiology and pathology. It covers biosynthesis and mechanisms of action and reviews their effects on brain and behaviour, spermatogenesis, hair growth, bones, muscles, erythropoiesis, the cardiovascular system and lipids, erection, and the prostate. Therapeutic uses of testosterone preparations are carefully evaluated, including use in women, the aging male, and its abuse and detection in sport. The book reviews applications in male contraception, the role of 5a-reductase inhibitors and the controversial use of DHEA. For this book the editors have assembled the world leaders in testosterone research and clinical andrology and endocrinology. A special feature of the book is the fact that its 24 chapters were submitted simultaneously to insure rapid publication. This revised and significantly expanded edition will serve as the standard source of reference for many years.

Table of Contents

Preface

1. Testosterone: an overview of biosynthesis, transport, metabolism and non-genomic actions F. F. G. Rommerts

2. The androgen receptor: molecular biology H. Klocker, J. Gromoll and A. C. B. Cato

3. Androgen receptor: pathophysiology O. Hiort and M. Zitzmann

4. Behavioural correlates of testosterone K. Christiansen

5. The role of testosterone in spermatogenesis G. F. Weinbauer, M. Niehaus and E. Nieschlag

6. Androgens and hair: a biological paradox V. A. Randall

7. Androgens and bone metabolism M. Zitzmann and E. Nieschlag

8. Testosterone effects on the skeletal muscle S. Bhasin, T. W. Storer, A. B. Singh, L. Woodhouse, R. Singh, J. Artaza, W. E. Taylor, I. Sinha-Hikim, R. Jasuja and N. Gonzalez-Cadavid

9. Androgens and erythropoiesis M. Zitzmann and E. Nieschlag

10. Testosterone and cardiovascular diseases A. von Eckardstein and F. C. W. Wu

11. Testosterone and erection H. M. Behre

12. Testosterone and the prostate J. T. Isaacs

13. Clinical use of testosterone in hypogonadism and other conditions E. Nieschlag and H. M. Behre

14. Pharmacology of testosterone preparations H. M. Behre, C. Wang, D. J. Handelsman and E. Nieschlag

15. Androgen therapy in non-gonadal disease P. Y. Liu and D. J. Handelsman

16. Androgens in male senescence J. M. Kaufman, G. T'Sjoen and A. Vermeulen

17. The pathobiology of androgens in women N. Burger and P. Casson

18. Clinical use of 5a-reductase inhibitors K. D. Kaufman

19. Dehydroepiandrosterone (DHEA) and androstenedione B. Allolio and W. Arlt

20. Selective androgen receptor modulators (SARMs) S. S. Wolf and M. Obendorf

21. Methodology for measuring testosterone, DHT and SHBG in a clinical setting M. Simoni

22. Synthesis and pharmacological profiling of new orally active steroidal androgens A. Grootenhuis, M. de Gooyer, J. van der Louw, R. Bursi and D. Leysen

23. Hormonal male contraception: the essential role of testosterone E. Nieschlag, A. Kamischke and H. M. Behre

24. Abuse of androgens and detection of illegal use W. Schä

nzer

Index.