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Professor Jaime Bosch is Professor of Medicine, and Senior Consultant Hepatologist and Chief at the Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic-Idibaps, University of Barcelona and Centro de Investigación Biomédica de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.
Guadalupe Garcia-Tsao, MD is Professor of Medicine, Department of Internal Medicine, Section of Digestive Diseases at Yale University School of Medicine.
Professor Francis Chan is Professor of Medicine and Therapeutics at The Chinese University of Hong Kong (CUHK) and an honorary consultant physician at the Prince of Wales Hospital (PWH).
List of contributors, x
Preface, xxv
Part 1: Symptoms, Syndromes, and Scenarios Discomfort above the diaphragm
1 Heartburn and noncardiac chest pain, 3Tiberiu Hershcovici and Ronnie Fass
2 Dysphagia and odynophagia, 11Stacey R. Zavala and Philip O. Katz
Discomfort below the diaphragm
3 Chronic or recurrent abdominal pain, 16Ayman Koteish and Anthony N. Kalloo
4 Dyspepsia: ulcer and non-ulcer/bloating and early satiety/belching and rumination, 22Alexander C. Ford and Paul Moayyedi
5 Nausea and vomiting, 26Jan Tack
Disorders of defecation
6 Diarrhea, 32Matthew R. Banks and Michael J. G. Farthing
7 Fecal incontinence, 43Ashok Attaluri and Satish S. C. Rao
8 Rectal bleeding, 47Benjamin Krevsky
9 Anorectal pain and pruritusani, 51Steven D. Wexner and Giovanna M. da Silva
Generalized ill health
10 Functional gastrointestinal disease, 54C. J. Hawkey, Jaime Bosch, Joel E. Richter, Guadalupe Garcia-Tsao, and Francis K. L. Chan
11 Anorexia nervosa and bulimia nervosa, 61Tomas J. Silber
12 Weight loss, 68Arvey I. Rogers, Hendrikus S. Vanderveldt and Amar R. Deshpande
13 Gastrointestinal causes of anemia and occult bleeding, 73Kevin A. Ghassemi, Dennis M. Jensen and Rome Jutabha
28 Benign esophageal strictures and caustic esophageal injury, 194Timothy T. Nostrant
Esophageal: malignant and pre-malignant
29 Barrett’s esophagus, 197Neil Gupta and Prateek Sharma
30 Esophageal cancer, 204Tamas A. Gonda and Charles J. Lightdale
Upper gastrointestinal infections
31 Infections of the esophagus and stomach, 214George B. McDonald
Gastroduodenal: benign
32 Peptic ulcer, 219C. J. Hawkey and John C. Atherton
33 Gastritis, 234Richard H. Lash and Robert M. Genta
Gastroduodenal: malignant and pre-malignant
34 Adenocarcinoma (gastric cancer and miscellaneous malignancy), 248Dai-ming Fan and Kai-chun Wu
35 Gastric lymphoma, 254Andrea Grin and Runjan Chetty
Motility disorders
36 Esophageal motility disorders, 258Peter J. Kahrilas
37 Gastric motility disorders, 265Jan Tack
Section 2: Disorders of the Small and Large Bowel Food, nutrition and malabsorption
38 Food allergy and intolerance, 272Stephan C. Bischoff and Katrin Feuser
39 Maldigestion and malabsorption, 279Arvey I. Rogers and Ryan D. Madanick
40 Celiac disease, 288Daniel A. Leffler, Andrés Cárdenas and Ciarán P. Kelly
41 Short bowel syndrome, 299Christian S. Jackson and Alan L. Buchman
42 Small intestinal bacterial overgrowth, 305Ahmed Abu Shanab, Rodrigo M. Quera and Eamonn M. M. Quigley
43 Bile acid malabsorption, 311Linda Wedlake and Jervoise Andreyev
44 Protein-losing disorders of the gastrointestinal tract, 318Simon Murch
Intestinal infections and infestations
45 Infective diarrhea, 324Michael J. G. Farthing and Anna Casburn-Jones
46 Travelers’ diarrhea, 338Andrew W. DuPont and Herbert L. DuPont
47 Abdominal tuberculosis, 342Bhupinder Anand
48 Parasites, 349John Croese
Inflammatory bowel disease
49 Ulcerative colitis, 355Fergus Shanahan
50 Crohn’s disease, 372Séverine Vermeire, Gert Van Assche and Paul Rutgeerts
51 Indeterminate colitis, 394Stephan R. Targan and C. J. Hawkey
52 Microscopic colitis, 399Frank Hoentjen, Chris Mulder and Gerd Bouma
53 Eosinophilic disorders of the gastrointestinal tract, 406Jon A. Vanderhoof and Rosemary J. Young
54 Pseudomembranous colitis, 412Tanya M. Monaghan and Yashwant R. Mahida
55 Ischemia/ischemic colitis, 417Aliya G. Hasan and Joel S. Levine
Malignant tumors
56 Small bowel tumours, 421Matthew P. Spinn and Sushovan Guha
57 Biology and genetics of colorectal cancer and polyps and polyposis, 428Ajay Goel and Christian Arnold
58 Colorectal cancer: screening and surveillance, 438Austin G. Acheson and John H. Scholefield
59 Colorectal cancer: a multidisciplinary approach, 444Rachel S. Midgley, Haitham M. Al-Salama, A. Merrie, N. Mortensen, and David J. Kerr
60 Obstruction and volvulus, 455Rakesh Bhardwaj and Michael C. Parker
61 Constipation and constipation syndromes, 462Adil E. Bharucha and Madhusudan Grover
62 Irritable bowel syndrome, 472Robin Spiller
63 Diverticular disease of the colon, 482Anish A. Sheth and Martin H. Floch
64 Megacolon and pseudo-obstruction, 488Eamonn M. M. Quigley
Other disorders of the small and large bowel
65 Splanchnic vascular disorders, 493J. Hajo van Bockel, Robert H. Geelkerken and Jeroen J. Kolkman
66 Drug-induced damage to the small and large intestine, 498Ingvar Bjarnason, Zeino Zeino and Guy Sisson
67 Acute appendicitis, 505John Simpson and David J. Humes
Anorectal diseases
68 Anorectal diseases, 511Steven D. Wexner and Giovanna M. da Silva
Section 3: Diseases of the Pancreas and Biliary Tract Pancreas
69 Acute pancreatitis, 518Georgios Papachristou, Vijay Singh and David C. Whitcomb
70 Chronic pancreatitis, 525Pascal O. Berberat, Güralp O. Ceyhan, Zilvinas Dambrauskas, Markus W. Büchler, and Helmut Friess
71 Pancreatic exocrine tumors, 533Paula Ghaneh and John P. Neoptolemos
72 Cysts and pseudocysts of the pancreas, 546Brian G. Turner and William R. Brugge
73 Development and miscellaneous abnormalities, 552Erica Makin and Mark Davenport
Biliary tract
74 Cholelithiasis, choledocholithiasis, and cholecystitis, 557Franz Ludwig Dumoulin and Tilman Sauerbruch
75 Sphincter of Oddi dysfunction, 567Dana C. Moffatt, Stuart Sherman and Evan L. Fogel
76 Primary sclerosing cholangitis, 573Sombat Treeprasertsuk and Keith D. Lindor
77 Cholangiocarcinoma, 580Konstantinos N. Lazaridis and Gregory J. Gores
Malformations
78 Congenital abnormalities of the biliary tract, 586Daniel Dhumeaux, Elie Serge Zafrani, Daniel Cherqui, and Alain Luciani
Section 4: Liver Disease
Infections
79 Acute viral hepatitis, 593Amer Skopic and Maria H. Sjogren
80 Chronic hepatitis B, 603Tarik Asselah, Olivier Lada, Rami Moucari, and Patrick Marcellin
81 Chronic viral hepatitis C, 610Xavier Forns and Jose M. Sánchez-Tapias
82 Chronic viral hepatitis D, 618Patrizia Farci and Maria Eliana Lai
83 Liver worms, 623Donald P. McManus
84 Liver protozoa, 630David Kershenobich, Guillermo Robles-Diaz and Juan Miguel Abdo Francis
85 Bacterial and fungal infections of the liver, 633Simon Rushbrook and Alexander Gimson
86 Primary biliary cirrhosis, 638Raoul Poupon
Autoimmune and related disorders
87 Autoimmune hepatitis and overlap syndromes, 642Heike Bantel, Kinan Rifai and Michael P. Manns
Genetic, metabolic and iatrogenic liver diseases
88 Alcoholic liver diseases, 649Jennifer T. Wells and Michael R. Lucey
89 Nonalcoholic fatty liver disease, 658Arthur J. McCullough and Srinivasan Dasarathy
90 Hemochromatosis, 675Antonello Pietrangelo
91 Alpha-1-antitrypsin deficiency, 683Feras T. Alissa and David H. Perlmutter
92 Wilson disease, 689Peter Ferenci
93 Drug prescription in liver disease, 695Guido Stirnimann and Jürg Reichen
94 Genetic and metabolic liver diseases in childhood, 700Giorgina Mieli-Vergani and Richard Thompson
95 Disturbances of bilirubin metabolism, 706Cristina Bellarosa and Claudio Tiribelli
Cirrhosis of the liver and its complications
96 Polycystic liver diseases, 713Luca Fabris, Catherine McCrann and Mario Strazzabosco
97 Cirrhosis of the liver, 719Gennaro D’Amico and Giuseppe Malizia
98 Portal hypertension, 728Juan Carlos García-Pagán, Roberto J. Groszmann and Jaime Bosch
99 Ascites and hepatorenal syndrome, 737Andrés Cárdenas and Pere Ginès
100 Spontaneous bacterial peritonitis, 745Guadalupe Garcia-Tsao
101 Hepatopulmonary syndrome and portopulmonary hypertension, 751Rajan Kochar and Michael B. Fallon
102 Hepatic encephalopathy, 757Thomas A. Brown and Kevin D. Mullen
103 Acute liver failure, 766John G. O’Grady and Julia Wendon
Other liver diseases
104 Tumors of the liver, 773Alejandro Forner, Carlos Rodríguez de Lope, María Reig, and Jordi Bruix
105 Vascular disorders of the liver, 786Dominique-Charles Valla
106 Granulomas of the liver, 793Miquel Bruguera Cortada and Rosa Miquel Morera
107 Liver diseases and pregnancy, 799J. Eileen Hay
Liver transplantation
108 Liver transplantation: indications and selection of candidates and immediate complications, 805Patrick S. Kamath and John J. Poterucha
109 Long-term management of recurrent primary liver disease, 813Kiran Bambha and Norah A. Terrault
Section 5: Diseases of Multiple Organ Systems
110 Collagen vascular and vasculitic disorders, 831Ulf Müller-Ladner and Jürgen Schölmerich
111 Systemic disease and the gastrointestinal tract, 839Paul J. Fortun
112 Pancreatic endocrine tumors, 844Robert T. Jensen
113 The carcinoid syndrome, 858Eva Tiensuu Janson and Kjell Öberg
114 AIDS and the gut, 865C. Mel Wilcox
115 Graft-versus-host disease, 873George B. McDonald
116 Radiation and other physicochemical injury, 879Keith Leiper and Andrew R. Moore
117 Systemic amyloidosis, 886Prayman T. Sattianayagam and Philip N. Hawkins
118 Foreign bodies, 893Lisa Swize and Patrick R. Pfau
119 Porphyria, 898Jean-Charles Deybach and Hervé Puy
120 The hereditary recurrent fevers, 908Elizabeth Drewe
Section 6: Abdominal Wall and Cavity
121 Abscesses and other intra-abdominal diseases, 913Juliane Bingener, Melanie L. Richards and Kenneth R. Sirinek
122 Hernia, 919Cindy Matsen and Leigh Neumayer
Part 3: Primer of Diagnostic Methods Endoscopic imaging
123 Upper gastrointestinal endoscopy and mucosal biopsy, 927Jayan Mannath and Krish Ragunath
124 Lower gastrointestinal endoscopy and biopsy, 936Jerome D. Waye
125 Endoscopic ultrasonography, 943V. Raman Muthusamy and Kenneth J. Chang
126 Diagnostic and interventional endoscopic retrograde cholangiopancreatography, 951George J. M. Webster and Stephen P. Pereira
127 Enteroscopy (double-balloon), 961Tomonori Yano and Hironori Yamamoto
128 Capsule endoscopy, 969Christina A. Tennyson and Blair S. Lewis
129 Confocal endomicroscopy, 975Martin Goetz and Ralf Kiesslich
130 Self-propelled colonoscopy, 983Menachem Moshkowitz and Nadir Arber Percutaneous imaging
131 Percutaneous ultrasound, 989Winnie C. W. Chu and Vivian Y. F. Leung
132 Barium radiology, 1000Simon A. Jackson and Bruce M. Fox
133 Computed tomography, 1006Karin Herrmann and Pablo R. Ros
134 Magnetic resonance imaging, 1014Luca Marciani, Robin C. Spiller, Penny A. Gowland, and Peter D. Thurley
135 Magnetic resonance cholangiopancreatography, 1021V. Anik Sahni and Koenraad J. Mortele
136 Virtual colonoscopy, 1027Abraham H. Dachman, Ila Sethi and Philippe Lefere
137 Positron emission tomography, 1035Sebastian Obrzut and Michael S. Kipper
138 Non-invasive liver assessment, 1042M. Beaugrand
Functional testing
139 Gastrointestinal motility testing, 1046Priyanka Sachdeva and Henry P. Parkman
140 Measurement of portal pressure, 1054Annalisa Berzigotti and Juan G. Abraldes
Tissue testing
141 Liver biopsy, 1060Cristina Ripoll and Rafael Bañares
142 Optimal tissue sampling: the pathologist’s perspective, 1066Richard H. Lash, Shari L. Taylor and Robert M. Genta
Part 4: Primer of Treatments
Medical treatments
143 Drug prescription in liver disease, 1077Guido Stirnimann and Jürg Reichen
144 Nutritional assessment and support, 1082T. E. Bowling
Therapeutic endoscopy
145 Variceal ligation, sclerotherapy, and other hemostatic techniques for varices and other lesions, 1092Louis-Michel Wong Kee Song
146 Non-variceal upper gastrointestinal bleeding, 1103Majid Almadi and Alan Barkun
147 Photodynamic therapy in the gastrointestinal tract, 1111Masoud Panjehpour and Bergein F. Overholt
148 Percutaneous endoscopic gastrostomy and jejunostomy, 1120Jeffrey L. Ponsky and Benjamin K. Poulose
149 Endoscopic techniques of removing early gastrointestinal neoplams, 1126Haruhiro Inoue and Hitomi Minami
150 Dilation and stenting of the gastrointestinal tract, 1134Lucio Petruzziello, Michele Marchese and Guido Costamagna
151 NOTES, 1142D. Nageshwar Reddy, G. V. Rao and Magnus J. Mansard
Percutaneous therapy
152 The transjugular intrahepatic portosystemic shunt (TIPS), 1147Christophe Bureau, Philippe Otal and Jean-Pierre Vinel
153 Interventional radiology, 1153Simon Chun-Ho Yu and Joyce Wai Yi Hui
154 Paracentesis, 1158Andrea De Gottardi, Chong-Meng Yeo and Guadalupe Garcia-Tsao
A synopsis of surgical operations
155 Liver operations, 1163J. Michael Henderson and Michael D. Johnson
156 Gastrointestinal operations, 1174Robert J. C. Steele
157 Minimally invasive surgery, 1182Todd A. Ponsky, Arjun Khosla and Jeffrey L. Ponsky
Index, 1191
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