A Textbook of Clinical Pharmacology

This thoroughly revised and updated edition provides a systematic approach to therapeutics based on modern understanding of pathophysiology and on basic pharmacological principles. This foundation is applied to the practical aspects of disease management to provide a logical and comprehensiveapproach to the rapidly evolving science of therapeutics. Emphasis is placed on recent advances throughout the text.

Foreword
Preface
Acknowledgements
Introduction to therapeutics	p. 3
Mechanisms of drug action (pharmacodynamics)	p. 9
Pharmacokinetics	p. 19
Drug absorption and routes of administration	p. 29
Drug metabolism	p. 41
Renal excretion of drugs	p. 51
Effects of disease on drug disposition	p. 55
Therapeutic drug monitoring	p. 67
Drugs in pregnancy	p. 73
Drugs at extremes of age	p. 83
Adverse drug reactions	p. 93
Drug interactions	p. 107
Pharmacogenetics	p. 119
Introduction of new drugs and clinical trials	p. 131
Hypnotics and anxiolytics	p. 147
Schizophrenia and behavioral emergencies	p. 159
Mood disorders	p. 169
Movement disorders	p. 181
Anticonvulsants	p. 193
Migraine	p. 205
Anesthetics and muscle relaxants	p. 211
Analgesics and the control of pain	p. 227
Anti-inflammatory drugs and the treatment of arthritis	p. 247
Prevention of atheroma: lowering plasma cholesterol and other approaches	p. 263
Hypertension	p. 279
Ischemic heart disease	p. 307
Anticoagulants and antiplatelet drugs	p. 321
Heart failure	p. 337
Cardiac arrhythmias	p. 349
Asthma and other respiratory disorders	p. 375
Alimentary system and liver	p. 395
Vitamins and other nutrients	p. 425
Drugs and the renal and genitourinary systems: fluid and electrolyte disorders	p. 437
Diabetes mellitus	p. 457
Thyroid	p. 469
Calcium metabolism	p. 477
Adrenal hormones	p. 485
Reproductive endocrinology	p. 497
Pituitary	p. 509
Antibacterial drugs	p. 517
Mycobacterial infections	p. 541
Fungal and viral infections	p. 551
HIV and AIDS	p. 565
Malaria and other parasitic infections	p. 577
Cancer chemotherapy	p. 585
Anemia and other hematological disorders	p. 615
Clinical immunopharmacology	p. 631
Drugs and the skin	p. 653
Drug and alcohol abuse	p. 667
Drug overdose and poisoning	p. 685
Appendix: Legal aspects of prescribing	p. 695
Index	p. 699
Table of Contents provided by Blackwell. All Rights Reserved.

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