A Textbook of Clinical Pharmacology

This textbook describes in detail the therapeutic use of the ever increasing catalogue of medical drugs available for prescription by a physician/nurse practitioner. All areas of drug prescribing are covered and have been updated since the previous edition (especially the rapidly changing fields of HIV treatment and biotechnology drugs). The book simply and poignantly describes modern therapeutic practice but also has highlighted key points for revision and challenging clinical pharmacology cases with fully explanatory answers for the reader to solidify their learning.

James M. Ritter is Professor of Clinical Pharmacology at Guy's, King's & St. Thomas's Medical Schools, London, UK.

Foreword

x

Preface

xi

Acknowledgements

xii

Part I General Principles

1

(132)

Introduction to Therapeutics

3

(5)

Mechanisms of Drug Action (Pharmacodynamics)

8

(9)

Pharmacokinetics

17

(9)

Drug Absorption and Routes of Administration

26

(11)

Drug Metabolism

37

(8)

Renal Excretion of Drugs

45

(4)

Effects of Disease on Drug Disposition

49

(10)

Therapeutic Drug Monitoring

59

(5)

Drugs in Pregnancy

64

(9)

Drugs in Infants and Children

73

(4)

Drugs in the Elderly

77

(7)

Adverse Drug Reactions

84

(13)

Drug Interactions

97

(11)

Pharmacogenetics

108

(11)

Introduction of New Drugs and Clinical Trials

119

(9)

Biotechnology and Gene Therapy

128

(5)

Part II The Nervous System

133

(92)

Hypnotics and Anxiolytics

135

(10)

Schizophrenia and Behavioural Emergencies

145

(8)

Mood Disorders

153

(11)

Movement Disorders and Degenerative CNS Disease

164

(14)

Anticonvulsants

178

(11)

Migraine

189

(5)

Anaesthetics and Muscle Relaxants

194

(16)

Analgesics and the Control of Pain

210

(15)

Part III The Musculoskeletal System

225

(14)

Anti-Inflammatory Drugs and the Treatment of Arthritis

227

(12)

Part IV The Cardiovascular System

239

(98)

Prevention of Atheroma: Lowering Plasma Cholesterol and Other Approaches

241

(14)

Hypertension

255

(24)

Ischaemic Heart Disease

279

(12)

Anticoagulants and Antiplatelet Drugs

291

(15)

Heart Failure

306

(11)

Cardiac Arrhythmias

317

(20)

Part V The Respiratory System

337

(20)

Therapy of Asthma, COAD and Other Respiratory Disorders

339

(18)

Part VI The Alimentary System

357

(40)

Alimentary System and Liver (with Dr Dipti Amin)

359

(29)

Vitamins and Other Nutrients

388

(9)

Part VII Fluids and Electrolytes

397

(18)

Drugs and the Renal and Genito-Urinary Systems: Fluid and Electrolyte Disorders

399

(16)

Part VIII The Endocrine System

415

(56)

Diabetes Mellitus

417

(11)

Thyroid

428

(7)

Calcium Metabolism

435

(8)

Adrenal Hormones

443

(8)

Reproductive Endocrinology (with Dr Dipti Amin)

451

(13)

The Pituitary Hormones and Related Drugs

464

(7)

Part IX Selective Toxicity

471

(98)

Antibacterial Drugs

473

(22)

Mycobacterial Infections

495

(9)

Fungal and Viral Infections

504

(16)

HIV and AIDS

520

(15)

Malaria and Other Parasitic Infections

535

(10)

Cancer Chemotherapy

545

(24)

Part X Haematology

569

(16)

Anaemia and Other Haematological Disorders

571

(14)

Part XI Immunopharmacology

585

(22)

Clinical Immunopharmacology

587

(20)

Part XII The Skin

607

(16)

Drugs and the Skin

609

(14)

Part XIII The Eye

623

(14)

Drugs and the Eye

625

(12)

Part XIV Clinical Toxicology

637

(32)

Drug and Alcohol Abuse

639

(19)

Drug Overdose and Poisoning

658

(11)

Index

669

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