A Textbook of Clinical Pharmacology

by Ritter, James M.; Lewis, Lionel D.; Mant, Timothy G. K.

• ISBN13: 9780340705933
• ISBN10: 0340705930
• Edition: 4th
• Format: Paperback
• Copyright: 2000-11-02
• Publisher: Hodder Education Publishers

Summary

This textbook describes in detail the therapeutic use of the ever increasing catalogue of medical drugs available for prescription by a physician/nurse practitioner. All areas of drug prescribing are covered and have been updated since the previous edition (especially the rapidly changing fields of HIV treatment and biotechnology drugs). The book simply and poignantly describes modern therapeutic practice but also has highlighted key points for revision and challenging clinical pharmacology cases with fully explanatory answers for the reader to solidify their learning.

Author Biography

James M. Ritter is Professor of Clinical Pharmacology at Guy's, King's & St. Thomas's Medical Schools, London, UK.

Table of Contents

Foreword	x
Preface	xi
Acknowledgements	xii
Part I General Principles	1	(132)
Introduction to Therapeutics	3	(5)
Mechanisms of Drug Action (Pharmacodynamics)	8	(9)
Pharmacokinetics	17	(9)
Drug Absorption and Routes of Administration	26	(11)
Drug Metabolism	37	(8)
Renal Excretion of Drugs	45	(4)
Effects of Disease on Drug Disposition	49	(10)
Therapeutic Drug Monitoring	59	(5)
Drugs in Pregnancy	64	(9)
Drugs in Infants and Children	73	(4)
Drugs in the Elderly	77	(7)
Adverse Drug Reactions	84	(13)
Drug Interactions	97	(11)
Pharmacogenetics	108	(11)
Introduction of New Drugs and Clinical Trials	119	(9)
Biotechnology and Gene Therapy	128	(5)
Part II The Nervous System	133	(92)
Hypnotics and Anxiolytics	135	(10)
Schizophrenia and Behavioural Emergencies	145	(8)
Mood Disorders	153	(11)
Movement Disorders and Degenerative CNS Disease	164	(14)
Anticonvulsants	178	(11)
Migraine	189	(5)
Anaesthetics and Muscle Relaxants	194	(16)
Analgesics and the Control of Pain	210	(15)
Part III The Musculoskeletal System	225	(14)
Anti-Inflammatory Drugs and the Treatment of Arthritis	227	(12)
Part IV The Cardiovascular System	239	(98)
Prevention of Atheroma: Lowering Plasma Cholesterol and Other Approaches	241	(14)
Hypertension	255	(24)
Ischaemic Heart Disease	279	(12)
Anticoagulants and Antiplatelet Drugs	291	(15)
Heart Failure	306	(11)
Cardiac Arrhythmias	317	(20)
Part V The Respiratory System	337	(20)
Therapy of Asthma, COAD and Other Respiratory Disorders	339	(18)
Part VI The Alimentary System	357	(40)
Alimentary System and Liver (with Dr Dipti Amin)	359	(29)
Vitamins and Other Nutrients	388	(9)
Part VII Fluids and Electrolytes	397	(18)
Drugs and the Renal and Genito-Urinary Systems: Fluid and Electrolyte Disorders	399	(16)
Part VIII The Endocrine System	415	(56)
Diabetes Mellitus	417	(11)
Thyroid	428	(7)
Calcium Metabolism	435	(8)
Adrenal Hormones	443	(8)
Reproductive Endocrinology (with Dr Dipti Amin)	451	(13)
The Pituitary Hormones and Related Drugs	464	(7)
Part IX Selective Toxicity	471	(98)
Antibacterial Drugs	473	(22)
Mycobacterial Infections	495	(9)
Fungal and Viral Infections	504	(16)
HIV and AIDS	520	(15)
Malaria and Other Parasitic Infections	535	(10)
Cancer Chemotherapy	545	(24)
Part X Haematology	569	(16)
Anaemia and Other Haematological Disorders	571	(14)
Part XI Immunopharmacology	585	(22)
Clinical Immunopharmacology	587	(20)
Part XII The Skin	607	(16)
Drugs and the Skin	609	(14)
Part XIII The Eye	623	(14)
Drugs and the Eye	625	(12)
Part XIV Clinical Toxicology	637	(32)
Drug and Alcohol Abuse	639	(19)
Drug Overdose and Poisoning	658	(11)
Index	669