A Textbook of Modern Toxicology

by Hodgson, Ernest

• ISBN13: 9780470462065
• ISBN10: 047046206X
• Edition: 4th
• Format: Hardcover
• Copyright: 2010-06-21
• Publisher: Wiley
• More Book Details
• Purchase Benefits

Summary

Toxicology is a multi-faceted field that requires a keen analytical eye. A Textbook of Modern Toxicology is a unique resource that provides both students and practitioners with an insightful overview of this discipline. This Fourth Edition adds chapters on new approaches to toxicology along with end-of-chapter questions and a solutions manual for academic adopters. Continuing its legacy as a valuable learning tool, this expert text will find a prominent place on the bookshelf of anyone studying this science.

Author Biography

ERNEST HODGSON, PhD, is Distinguished Professor Emeritus of Toxicology at North Carolina State University. In addition to the previous editions of A Textbook of Modern Toxicology, he coedited Molecular and Biochemical Toxicology, Fourth Edition (Wiley) and its prior editions. Dr. Hodgson is the Editor of the Journal of Biochemical and Molecular Toxicology.

Table of Contents

Introduction

Introduction

Definition and Scope

Relationship to Other Sciences

A Brief History of Toxicology

Dose-Response Relationships

Sources of Toxic Compounds

Movement of Toxicants in the Environment

Suggested Reading

Sample Questions

Introduction to Biochemical and Molecular Methods in Toxicology

Introduction

Cell Culture Techniques

Molecular Techniques

Immunochemical Techniques

Proteomics

Metabolomics

Bioinformatics

Summary and Conclusions

Suggested Reading

Sample Questions

Classes of Toxicants

Exposure Classes, Toxicants in Air, Water, Soil, Domestic and Occupational Settings

Air Pollutants

Water and Soil Pollutants

Occupational Toxicants

Suggested Reading

Sample Questions

Classes of Toxicants: Use Classes

Introduction

Metals

Agricultural Chemicals (Pesticides)

Food Additives and Contaminants

Toxins

Solvents

Therapeutic Drugs

Drugs of Abuse

Combustion Products

Cosmetics

Suggested Reading

Sample Questions

Toxicant Processing In Vivo

Absorption and Distribution of Toxicants

Introduction

Cell Membranes

Mechanisms of Transport

Physicochemical Properties Relevant to Diffusion

Routes of Absorption

Toxicant Distribution

Toxicokinetics

Suggested Reading

Sample Questions

Metabolism of Toxicants

Introduction

Phase I Reactions

Phase II Reactions

Suggested Reading

Sample Questions

Reactive Metabolites

Introduction

Activation Enzymes

Nature and Stability of Reactive Metabolites

Fate of Reactive Metabolites

Factors Affecting Toxicity of Reactive Metabolites

Reactive Oxygen Species

Examples of Activating Reactions

Summary and Conclusions

Suggested Reading

Sample Questions

Chemical and Physiological Influences on Xenobiotic Metabolism

Introduction

Nutritional Effects

Physiological Effects

Comparative and Genetic Effects

Chemical Effects

Environmental Effects

Summary and Conclusions

Suggested Reading

Sample Questions

Elimination of Toxicants

Introduction

Transport

Renal Elimination

Hepatic Elimination

Respiratory Elimination

Conclusion

Suggested Reading

Sample Questions

Toxic Action

Acute Toxicity

Introduction

Acute Exposure and Effect

Dose-Response Relationships

Non-Conventional Dose-Response Relationships

Alternative Methods

Mechanisms of Acute Toxicity

Suggested Reading

Sample Questions

Chemical Carcinogenesis

DNA Damage and Mutagenesis

General Aspects of Cancer

Human Cancer

Classes of Agents That Are Associated with Carcinogenesis

General Aspects of Chemical Carcinogenesis

Oncogenes

Tumor Suppressor Genes

Suggested Reading

Sample Questions

Teratogenesis

Introduction

Overview of Embryonic Development

Principles of Teratogenesis

Mechanisms of Teratogenesis

Future Considerations

Suggested Reading

Sample Questions

Organ Toxicity

Hepatotoxicity

Introduction

Susceptibility of the Liver

Types of Liver Injury

Mechanisms of Hepatotoxicity

Examples of Hepatotoxicants

Metabolic Activation of Hepatotoxicants

Suggested Reading

Sample Questions

Nephrotoxicity

Introduction

Factors Contributing to Nephrotoxicity

Examples of Nephrotoxicants

Summary

Suggested Reading

Sample Questions

Toxicology of the Nervous System

Introduction

The Nervous System

Toxicant Effects on the Nervous System

Neurotoxicity Testing

Summary

Suggested Reading

Sample Questions

Reproductive System

Introduction

The-Hypothalamic-Pituitary-Gonadal Axis

Male Reproductive Physiology

Disruption of Male Reproduction by Toxicants

Female Reproductive Physiology

Disruption of Female Reproduction by Toxicants

Summary

Suggested Reading

Sample Questions

Endocrine System

Introduction

Endocrine System

Endocrine Disruption

Incidents of Endocrine Toxicity

Conclusion

Suggested Reading

Sample Questions

Respiratory Toxicity

Introduction

Anatomy and Function of the Respiratory Tract

Toxicant-Induced Lung Injury, Remodeling and Repair

Occupational and Environmental Lung Diseases

Suggested Reading

Sample Questions

Immunotoxicity

Introduction

The Immune System

Immune Suppression

Classification of Immune-Mediated Injury (Hypersensitivity)

Effects of Chemicals on Allergic Disease

Other Issues: Autoimmunity, and the Developing Immune System

Suggested Reading

Sample Questions

Applied Toxicology

Toxicity Testing

Introduction

Experimental Administration of Toxicants

Chemical and Physical Properties

Exposure and Environmental Fate

In Vivo Tests

In Vitro and Other Short-Term Tests

Ecological Effects

Risk Analysis

The Future of Toxicity Testing

Suggested Reading

Sample Questions

Forensic and Clinical Toxicology

Introduction

Forensic Toxicology

Clinical Toxicology

Analytical Methods in Forensic and Clinical Toxicology

Suggested Reading

Sample Questions

Prevention of Toxicity

Introduction

Legislation and Regulation

Prevention in Different Environments

Education

Suggested Reading

Sample Questions

Human Health Risk Assessment

Introduction

Risk Assessment Methods

Non-Cancer Risk Assessment

Cancer Risk Assessment

PBPK Modeling

Suggested Reading

Sample Questions

Environmental Toxicology

Toxicant Analysis

Introduction

Environmental Sample Collection Methods

Analytical Techbiques

Quantification, Quality Assurance and Quality Control

Summary

Suggested Reading

Sample Questions

Basics of Environmental Toxicology

Introduction

Environmental Persistence

Bioaccumulation

Toxicity

Conclusion

Suggested Reading

Sample Questions

Transport and Fate of Toxicants in the Environment

Introduction

Sources of Toxicants to the Environment

Transport Processes

Equilibrium Partitioning

Transformation Processes

Environmental Fate Models

Suggested Reading

Sample Questions

Ecological Risk Assessment

Introduction

Formulating the Problem

Analyzing Exposure and Effects Information

Characterizing Risk

Managing Risk

Suggested Reading

Sample Questions

New Approaches in Toxicology

Perspectives on Informatics in Toxicology

Introduction

Transcriptomics

Annotation Resources

Genome Sequencing, Re-sequencing and Genotyping

Epigenomic Profiling

Computation Toxicology

Informatics Tools in Toxicology

Suggested Reading

Sample Questions

Future Considerations

Introduction

Risk Assessment

Risk Management

Risk Communication

In Vivo Toxicity

In Vitro Toxicity

Molecular and Biochemical Toxicology

Development of Selective Toxicants

Summary and Conclusions

Suggested Reading

Sample Questions

Glossary

Index

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