Thalassemia: An Issue of Hematology/Oncology Clinics of North America

by Forget, Bernard G.

• ISBN13: 9781437725315
• ISBN10: 1437725317
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-12-01
• Publisher: SAUNDERS W B CO

Summary

Thalassemia is discussed comprehensively by the authors in this issue. Topics discussed include the population genetics and dynamimcs of thalassemia, alpha thalassemia, HbE/beta thalassemia, management of iron overload in thalassemia syndromes, allogeneic cellular gene therapy for hemoglobinopathies, cord blood transplantation for beta thalassemia major, and gene therapy for hemoglobin disorders.

Table of Contents

Preface: Thalassemia	p. xiii
Thalassemia: An Overview of 50 Years of Clinical Research	p. 1005
The Population Genetics and Dynamics of the Thalassemias	p. 1021
The Molecular Basis of ¿-Thalassemia: A Model for Understanding Human Molecular Genetic	p. 1033
HbE/ß-Thalassemia: Basis of Marked Clinical Diversity	p. 1055
Protein Quality Control During Erythropoiesis and Hemoglobin Synthesis	p. 1071
Anemia, Ineffective Erythropoiesis, and Hepcidin: Interacting Factors in Abnormal Iron Metabolism Leading to Iron Overland in ß-Thalassemia	p. 1089
Iron Overland in Thalassemia and Related Conditions: Therapeutic Goals and Assessment of Response to Chelation Therapies	p. 1109
Pharmacologic Induction of Fetal Hemoglobin Production	p. 1131
Allogeneic Cellular Gene Therapy for Hemoglobinopathies	p. 1145
Umbilical Cord Blood Transplantation for Thalassemia Major	p. 1165
Noninvasive Approaches to Prenatal Diagnosis of Hemoglobinopathies Using Fetal DNA in Maternal Plasma	p. 1179
Hemoglobin Gene Therapy for ß-Thalassemia	p. 1187
Bonus Articles	p. 1203
Mouse Models of Inherited Cancer Syndromes	p. 1205
Lower Gastrointestinal Tract Cancer Predisposition Syndromes	p. 1229
Index	p. 1253
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