Summary

The second of two volumes, Thymosins in Health and Disease II, continues the exploration of the rapidly expanding area of research in thymosins-a family of proteins, with a broad set of biological properties and great clinical potential. In this volume, papers detail the important therapeutic implications of two thymosins: Thymosin Î±1 (TÎ±1) in relation to immunity, infectious diseases, and cancer, and the clinical and preclinical applications of Thymosin (TÎ²4) in cardiovascular regeneration and wound healing. In addition, this volume covers some of the most current topics in thymosin research, including nuclear magnetic resonance imaging structural studies of thymosins, thymosin labeling, antibodies in thymosin research, and new methods for thymosin delivery. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.

Author Biography

Allan L. Goldstein is professor and Catharine B. & William McCormick Chair of the department of Biochemistry and Molecular Biology at The George Washington University School of Medicine and Health Sciences, where he has served since 1978. He is a world-renowned authority on the thymus gland and the workings of the immune system, and co-discoverer of the thymosins.

Dr. Goldstein is the author of over 400 scientific articles in professional journals, the inventor on more than 15 U.S. Patents, and the editor of several books in the fields of biochemistry, biomedicine, immunology and neuroscience.

He is on the editorial boards of numerous scientific and medical journals and has been a consultant to many research organizations in industry and government; co-founder of The Institute for Advanced Studies in Aging and Geriatric Medicine, a non-profit research and educational institute; a member of the Board of Trustees of the Albert Sabin Vaccine Institute; and serves as the Chairman of the Board of RegeneRx Biopharmaceuticals.

Dr. Goldstein received his B.S. from Wagner College in 1959 and his M.S. and Ph.D. from Rutgers University in 1964. He served as a faculty member of the Albert Einstein College of Medicine from 1964 to 1972, and moved to the University of Texas Medical Branch in Galveston in 1972 as professor and director of the division of Biochemistry.

Introduction for Thymosins in Health and Disease vii
Allan I. Goldstein and Enrico Garaci

Thymosin &alpha1: immunomodulation, immunopharmacology, infectious diseases, and cancers

Thymosin α1: a novel therapeutic option for patients with refractory chronic purulent rhinosinusitis 1
Virgil A. S. H. Dalm, Harm de Wit and Hemmo A. Drexhage

Thymosin α1: in melanoma: from the clinical trial setting to the daily practice and beyond 8
Riccardo Danielli, Ester Fonsatti, Luana Calabrò, Anna Maria Di Giacomo and Michele Maio

Thymosin α1 as a stimulatory agent of innate cell-mediated immune response 13
Annalucia Serafino, Pasquale Pierimarchi, Francesca Pica, Federica Andreola, Roberta Gaziano, Noemi Moroni, Manuela Zonfrillo, Paola Sinibaldi-Vallebona and Enrico Garaci

Thymosin α1 continues to show promise as an enhancer for vaccine response 21
Cynthia Tuthill, Israel Rios, Alfonso De Rosa and Roberto Camerini

Clinical and preclinical applications of thymosin β4: wound healing, eye injuries, cardiovascular diseases, and neurological injuries

The use of angiogenic-antimicrobial agents in experimental wounds in animals: problems and solutions 28
Paritosh Suman, Harikrishman Ramachandran, Sossy Sahakian, Kamraan Z. Gill, Basil A. J. Horst, Shnta M. Modak and mark A. Hardy

The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients 37
Terry Treadwell, Hynda K. Kleinman, David Crockford, mark A. Hardy, Georgio T. Guarnera and Allan L. Goldstein

Thymosin β4: a potential novel dry eye therapy 45
Gabriel Sosne, Ping Qiu, George W. Ousler 3rd, Steven P. Dunn and David Crockford

Neuroprotective and neurorestorative effects of thymosin β4 treatment following experimental traumatic brain injury 51
Ye Xiong, Asim Mahmood, Yuling Meng, Tanlu Zhang, Zheng gang Zhang, Daniel C. Morris and Michael Chopp

Use of the cardioprotectants thymosin β4 and dexrazoxane during congenial heart surgery: proposal for a randomized, double-blind, clinical trial 59
Daniel Stromberg, Tia Raymond, David Samuel, David Crockford, William Stigall, Steven Leonard, Eric Mendeloff and Andrew Gormley

Cardiac repair with thymosin β4 and cardiac reprogramming factors 66
Deepak Srivastava, Masaki Ieda, Jidong Fu and Li Qian

Late breaking paper session

NMR structural studies of thymosin α1 and β-thymosins 73
David E. Volk, Cynthia W. Tuthill, Miguel-Angel Elizondo-Riojas and David G. Gorenstein

Fragments of β-thymosin from the sea urchin Paracentrotus lividus as potential antimicrobial peptides against staphylococcal biofilms 79
Domenico Schillaci, Maria Vitale, Maria Grazia Cusimano and Vincenzo Arizza

Development of an analytical HPLC methodology to study the effects of thymosin β4 on actin in sputum of cystic fibrosis patients 86
Mahnaz Badamchain, Ali A. Damavandy and Allan L. Goldstein

The role of biologically active peptides in tissue repair using umbilical cord mesenchymal stem cells 93
Carlos Cabrena, Gabriela Carriquiry, Chiara Pierinelli, Nancy Reinoso, Javier Arias-Stella and Javier Paino

Identification on interaction partners of β-thymosins: applications of thymosin β4 labeled by transglutaminase 98
Christine App, Jana Knop, Hans Georg Mannherz and Ewald Hannappel

Antibodies in research of thymosin β4: investigation of cross-reactivity and influence of fixatives 105
Jana Knop, Christine App and Ewald Hannappel

Thymosin β4 sustained release from poly(lactide-co-glycolide) microspeheres: synthesis and implications for treatment of myocardial ischemia 112
Jeffrey E. Thatcher, Tré Welch, Robert C. Eberhart, Zoltan A. Schelly and J. Michael DiMaio

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