Tissue Restoration Through Regenerative Biology and Medicine

by Stocum, David L.; Beck, F.; Christ, B.; Kriz, W.; Marani, E.; Kummer, W.; Putz, R.

• ISBN13: 9783540206033
• ISBN10: 3540206035
• Format: Paperback
• Copyright: 2004-04-01
• Publisher: Springer Verlag

Summary

Indiana Univ., Indianapolis. Summarizes the depth of understanding about the mechanisms of regeneration in some selected mammalian tissues and discusses strategies for defining the molecular requirements for the chemical induction of regeneration. Softcover.

Table of Contents

1 Introduction	1	(46)
1.1 The Biology of Regeneration	3	(1)
1.2 Regeneration of Ectodermal Derivatives	4	(17)
1.2.1 Uninjured Epidermis	4	(1)
1.2.2 Injured Epidermis	5	(2)
1.2.3 Hair	7	(1)
1.2.4 Nervous System	8	(13)
1.2.4.1 Axon Regeneration in Mammals	9	(4)
1.2.4.2 Regeneration of Amphibian and Avian Optic Nerves	13	(1)
1.2.4.3 Axon Regeneration in the Amphibian Spinal Cord	14	(2)
1.2.4.4 Neurogenesis in the Regenerating Amphibian Tail	16	(2)
1.2.4.5 Neurogenesis in the Adult Mammalian Brain	18	(2)
1.2.4.6 Injury-Induced Neurogenesis	20	(1)
1.3 Regeneration of Endodermal Derivatives	21	(7)
1.3.1 Liver	21	(6)
1.3.1.1 Proliferation Capacity and Kinetics	22	(1)
1.3.1.2 Gene Activity of Proliferation	23	(1)
1.3.1.3 Initiation of Liver Regeneration	24	(2)
1.3.1.4 Stopping Proliferation	26	(1)
1.3.1.5 Remodeling	26	(1)
1.3.1.6 Liver Regeneration via Stem Cells	27	(1)
1.3.2 Pancreas	27	(1)
1.4 Regeneration of Mesodermal Derivatives	28	(9)
1.4.1 Skeletal Muscle	29	(4)
1.4.1.1 Origin of Regenerated Myofibers	29	(1)
1.4.1.2 Cellular and Molecular Events of Muscle Regeneration	30	(2)
1.4.1.3 Regulation of Muscle Regeneration by Growth Factors	32	(1)
1.4.2 Bone	33	(3)
1.4.2.1 Bone Regenerates via Mesenchymal Stem Cells	33	(1)
1.4.2.2 Regulation of Bone Regeneration by Growth Factors	34	(2)
1.4.3 Blood and Lymphoid Cells	36	(1)
1.5 Developmental Potential of Adult Stem Cells	37	(10)
1.5.1 Neural Stem Cells	38	(1)
1.5.2 Hepatic Oval Cells	39	(1)
1.5.3 Satellite Cells	40	(1)
1.5.4 Bone Marrow Cells	40	(4)
1.5.4.1 Unfractionated Bone Marrow	40	(1)
1.5.4.2 Hematopoietic Stem Cells	41	(1)
1.5.4.3 Mesenchymal Stem Cells	42	(1)
1.5.4.4 Multipotential Adult Progenitor Cells of Bone Marrow	43	(1)
1.5.5 What Is the Basis of Adult Stem Cell Potency?	44	(3)
2 Regenerative Medicine	47	(28)
2.1 Cell Transplants	47	(10)
2.1.1 Central Nervous System	49	(2)
2.1.1.1 Demyelinating Disorders	49	(1)
2.1.1.2 Spinal Cord Injury	50	(1)
2.1.1.3 Parkinson's Disease	50	(1)
2.1.2 Myocardial Infarction	51	(2)
2.1.3 Osteogenesis Imperfecta	53	(1)
2.1.4 Diabetes	53	(1)
2.1.5 Skin Injuries	54	(1)
2.1.6 Cartilage and Bone Injuries	55	(1)
2.1.7 Research Issues in Cell Transplantation	55	(2)
2.1.7.1 Cell Sources	55	(1)
2.1.7.2 Biomaterials for Bioartificial Tissues	56	(1)
2.2 Chemical Induction of Regeneration in Vivo	57	(18)
2.2.1 Evidence for Latent Regenerative Capacity in Mammals	57	(3)
2.2.1.1 New Cardiomyocytes Appear After Myocardial Infarction	57	(2)
2.2.1.2 Stem Cells Reside in Non-regenerating Tissues	59	(1)
2.2.1.3 Induction of Dedifferentiation of Mouse Myotubes	59	(1)
2.2.2 Interventions to Promote Regeneration in Vivo	60	(7)
2.2.2.1 Peripheral Nerve	60	(1)
2.2.2.2 Spinal Cord Injury	61	(4)
2.2.2.3 Parkinson's Disease	65	(1)
2.2.2.4 Bone and Cartilage	65	(1)
2.2.2.5 Skin Wounds	66	(1)
2.2.2.6 Use of Pig Small Intestine and Urinary Bladder Submucosa as a Regeneration Template	67	(1)
2.2.3 Strategies to Define the Molecular Requirements for Chemical Induction of Regeneration	67	(8)
2.2.3.1 Comparison of Mutant Vs Wild-Type Tissues	68	(1)
2.2.3.2 Comparison of Regeneration-Competent Vs Regeneration-Deficient Stages of the Life Cycle	69	(4)
2.2.3.3 Regeneration-Competent Vs Regeneration-Deficient Species	73	(2)
3 Perspectives	75	(2)
References	77	(26)
Subject Index	103