Toll-Like Receptor Family Members and Their Ligands

by Beutler, Bruce; Wagner, Hermann

• ISBN13: 9783540435600
• ISBN10: 3540435603
• Format: Hardcover
• Copyright: 2002-12-01
• Publisher: Springer Verlag

Summary

The innate immune system is sometimes referred to as the "primitive" immune system. Perhaps this has dissuaded immunologists from analyzing it so energetically as they have analyzed the adaptive immune system during the past two decades. But while its phylogenetic origins are indeed ancient, and though it is "of the first type", there is nothing crude, nothing unsophisticated, and nothing "inferior" about innate immunity. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last due.

Table of Contents

Evolution of the TIR, Tolls and TLRs: Functional Inferences from Computational Biology	1	(23)
B. Beutler
M. Rehli
Plant Disease Resistance: Commonality and Novelty in Multicellular Innate Immunity	23	(24)
R. Fluhr
R.N. Kaplan-Levy
Signal Transduction Pathways Activated by the IL-1 Receptor/Toll-Like Receptor Superfamily	47	(16)
L.A.J. O'Neill
Toll Receptors in Drosophila: a Family of Molecules Regulating Development and Immunity	63	(18)
J.L. Imler
J.A. Hoffmann
Toll-Like Receptors and Their Ligands	81	(12)
G.M. Barton
R. Medzhitov
Toll-Like Receptor-5 and the Innate Immune Response to Bacterial Flagellin	93	(16)
K.D. Smith
A. Ozinsky
TLR4 as the Mammalian Endotoxin Sensor	109	(12)
B. Beutler
TLR2: Cellular Sensor for Microbial and Endogenous Molecular Patterns	121	(24)
C.J. Kirschning
R.R. Schumann
Bacterial CpG-DNA Licenses TLR9	145	(10)
S. Bauer
H. Wagner
MyD88 as a Bottle Neck in Toll/IL-1 Signaling	155	(14)
O. Takeuchi
S. Akira
Heat Shock Proteins as Ligands of Toll-Like Receptors	169	(16)
R.M. Vabulas
H. Wagner
H. Schild
Subject Index	185