Toxicology of Skin

by Maibach; Howard I.

• ISBN13: 9781560328025
• ISBN10: 1560328029
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-03-15
• Publisher: CRC Press

Summary

Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. This benchmark volume provides the latest findings in skin toxicology in one definitive source. Toxicology of the Skin is part of the highly acclaimed Target Organ Toxicology Series-a leading series of reviews by internationally renowned experts in their respective fields. Dermatologists and toxicology specialists will find this text indispensable.

Table of Contents

I. Irritant Dermatitis
Electron Paramagnetic Resonance Study for Defining the Mechanism of Irritant Dermatitis	3	(20)
Yoshiaki Kawasaki
Jun-ichi Mizushima
Roger Cooke
Howard I. Maibach
Irritant Patch Test in Atopic Individuals	23	(8)
Harald Loeffler
Isaak Effendy
Quantification of Nonerythematous Irritant Dermatitis	31	(8)
Veranne Charbonnier
Howard I. Maibach
Boyce M. Morrison, Jr.
Marc Paye
Detergents	39	(12)
Isaak Effendy
Howard I. Maibach
Permeability of Skin for Metal Compunds	51	(22)
Jurij J. Hostynek
Irritant Dermatitis: Subthreshold Irritation	73	(12)
Ethel Tur
Cytokines and Irritant Dermatitis Syndrome	85	(20)
Isaak Effendy
Howard I. Maibach
Assay to Quantify Subjective Irritation Caused by the Pyrethroid Insecticide Alpha-Cypermethrin	105	(10)
Rudolf A. Herbst
Robert B. Strimling
Howard I. Maibach
Prediction of Skin Corrosivity Using Quantitative Structure-Activity Relationships	115	(14)
Martin D. Barratt
II. Percutaneous Absorption
Contamination and Percutaneous Absorption of Chemicals from Water and Soil	129	(16)
Ronald C. Wester
Howard I. Maibach
Determining an Occupational Dermal Exposure Biomarker for Atrazine through Measurement of Metabolites in Human Urine by HPLC-Accelerator Mass Spectrometry	145	(14)
Bruce A. Buchholz
John S. Vogel
S. Douglas Gilman
Shirley J. Gee
Bruce D. Hammock
Xiaoying Hui
Ronald C. Wester
Howard I. Maibach
Partitioning of Chemicals from Water into Powdered Human Stratum Corneum (Callus)	159	(20)
Xiaoying Hui
Ronald C. Wester
Philip S. Magee
Howard I. Maibach
Dermal Exposure of Hands to Pesticides	179	(4)
Graham A. Matthews
Iontophoresis	183	(14)
Angela N. Anigbogu
Howard I. Maibach
Penetration and Barrier Creams	197	(10)
Hongbo Zhai
Howard I. Maibach
III. Allergic Contact Dermatitis
Fiber	207	(28)
Kathryn L. Hatch
Howard I. Maibach
Novel Topical Agents for Prevention and Treatment of Allergic and Irritant Contact Dermatitis	235	(28)
John J. Wille
Agis F. Kydonieus
Allergic Contact Dermatitis: Clinical Considerations	263	(8)
Yung-Hian Leow
Howard I. Maibach
Pharmacology, Toxicology, and Immunology of Experimental Contact Sensitizers	271	(22)
Whitney Hannon
Tim Chartier
J. Richard Taylor
Modulation of the Dermal Immune Response by Acute Restraint	293	(14)
Sally S. Tinkle
Melanie S. Flint
Textile-Dye Allergic Contact Dermatitis Prevalence	307	(16)
Kathryn L. Hatch
Howard I. Maibach
Dose-Response Studies in Guinea Pig Allergy Tests	323	(22)
Søren Frankild
Operational Definition of Allergic Contact Dermatitis	345	(12)
S. Iris Ale
Howard I. Maibach
Predictive Immunotoxicological Risk Assessment	357	(14)
B. Homey
P. Lehmann
H. W. Vohr
Allergic Contact Dermatitis from Transdermal Systems	371	(12)
Cheryl Levin
Howard I. Maibach
IV. Contact Urticaria
Animal Models for Immunologic Contact Urticaria and Nonimmunologic Contact Urticaria	383	(6)
Antti I. Lauerma
Howard I. Maibach
Diagnostic Tests in Dermatology	389	(14)
Smita Amin
Antti I. Lauerma
Howard I. Maibach
V. Miscellaneous
Wound Healing Products	403	(42)
David W. Hobson
Issues of Toxicity with Dermatologic Drugs During Pregnancy	445	(44)
Barbara R. Reed
Roles of Calcium Ions in Skin Barrier	489	(12)
Hanafi Tanojo
Howard I. Maibach
Nuclear Receptors for Psoralen in Cultured Human Skin Fibroblasts	501	(12)
K. Milioni
E. Bloom
H. I. Maibach
In Vitro Viability Assays	513	(18)
Mikyung Kwah
Dermal Penetration of Calcium Salts and Calcinosis Cutis	531	(14)
Stephen D. Soileau
Index	545