Trace Elements in Man and Animals 10

by International Symposium on Trace Elements in Man and Animals (10th : 1999 : Evian, France); Anderson, Richard Allen

• ISBN13: 9780306463785
• ISBN10: 0306463784
• Format: Hardcover
• Copyright: 2000-07-01
• Publisher: Plenum Pub Corp

Summary

Proceedings of the 10th International Symposium on Trace Elements in Man and Animals (TEMA 10), held May 2-7, 1999, in Evian, France. This volume containing the proceedings of the tenth of the highly successful TEMA meetings, presents recent progress in the research on the functional role and metabolism of trace elements, and new developments in the understanding of molecular and cellular biology. Various contributions providing new data on zinc and copper transport mechanisms, enable a global view of the molecular metabolism of these metals in the human body, whilst other particularly dramatic results presented here offer new perspectives on the epidemiology of trace elements deficiency and supplementation. Also included are the results of recent major trials demonstrating the beneficial effect of selenium on human health. The spectacular growth of interest in the field of selenium, with the discovery of new selenoproteins and biological roles, is represented here along with the other areas of particular progress the research into boron and chromium, which have marked this year's meeting.

Table of Contents

UNDERWOOD MEMORIAL LECTURE
Integrative Aspects of Zinc Metabolism and Function	1	(8)
Robert J. Cousins
I. CELLULAR AND MOLECULAR BIOLOGY OF TRACE ELEMENTS
Trace Elements Cellular Metabolims
The Copper Transporting ATPases in Human Disease	9	(6)
Jonathan D. Gitlin
Regulation and Function of the Copper Ion Transport Machinery	15	(6)
Jaekwon Lee
Dennis J. Thiele
Control of Gene Expression of Glutathione Peroxidase-1 and Other Selenoproteins in Rats and Cultured Cells	21	(8)
Roger A. Sunde
Jacqueline K. Evenson
Cellular and Subcellular Distribution of Selenium and Selenium-Containing Proteins in the Rat	29	(6)
Dietrich Behne
Henning Pfeifer
Doris Rothlein
Antonios Kyriakopoulos
The Mechanism and Regulation of Zinc Transport in Yeast	35	(8)
David J. Eide
Metallothionein Facilitates Zinc Absorption in Zinc Deficient Mice but Limits Absorption in Zinc Replete Mice	43	(4)
P. Coyle
J. C. Philcox
A. M. Rofe
Metallothionein and Innate Activation of Primary Human and Mouse Monocytes	47	(4)
James Koropatnick
Suzanne Dale
Rudolfs K. Zalups
Role of Metallothionein on Zn, Cu, Cd Au, and Ag Accumulation in Hepatic Cytosol of Heavy Metal-Injected Rats	51	(4)
S. Saito
K. Yoshida
Molecular Cloning of a Human cDNA Regulated by Heavy Metals	55	(4)
M. G. Pagliuca
S. Cigliano
R. Lerose
A. Leone
Distribution of Copper Transported ATP7B in Embryo and New Born Rat	59	(4)
T. Hosokawa
M. Okabe
M. Kurasaki
A. Hata
F. Endo
K. Nagano
I. Matsuda
K. Urakami
T. Saito
Interaction between Copper and Iron Metabolism in the Human Intestinal Caco-2 Cells	63	(2)
I. Gabrielli
Y. Sambuy
S. Ferruzza
M. L. Scarino
Induction of Metallothioneins by Zinc (Zn) Supplementation Quantification in Young Rat Tissues	65	(2)
G. S. Henriques
S. M. F. Cozzolino
Trace Elements and Oxidative Stress
Iron, Oxidative Stress, the HFE Gene, and Lung Cancer	67	(4)
J. M. McCord
S. K. Bose
B. Gao
Selenium and the Protection against Peroxynitrite	71	(6)
Helmut Sies
Lars-Oliver Klotz
Stefan M. Schieke
Karlis Briviba
Gavin E. Arteel
Cooperative Effects of Zinc/Selenium and Thiols in the Protection against UV-Induced Genomic DNA Damage	77	(6)
Marie-Jeanne Richard
Nathale Emonet-Piccardi
Christine Didier
Eric Jourdan
Marie-Therese Leccia
Marie-Odile Parat
Jean Cadet
Jean C. Beani
Alain Favier
Trace Elements and Enzyme Redox Centers	83	(6)
Marc Fontecave
Importance of Trace Elements in Transcription Factor NF-κB Activation	89	(8)
Jacques Piette
Trace Elements: Metabolism and Oxidative Modifications of Lipoproteins	97	(8)
Y. Rayssiguier
A. Mazur
Co-localization of Cu/Zn-Superoxide Dismutase (SOD-1), Nitric Oxide Synthase (NOS), and Zn/Cu-Metallothionein (MT) in Rat Brain	105	(6)
Masashi Okabe
Toshiyuki Hosokawa
Shigeru Saito
Takeshi Saito
Masaaki Kurasaki
Hidesuke Shimizu
Effect of Dolomite and Thiamine Supplementation on Serum Total Antioxidant Status and Bioelements Concentration in Lead-Intoxicated Rats	111	(4)
Z. Krejpcio
R. Wojciak
Protective Effects of Antioxidants on Iron-Induced Free Radical-Mediated Damaging Processes in Humans and Animals	115	(4)
Igor Afanas'ev
Elena Ostrachovich
Irina Deeva
Ludmila Korkina
Complexes of Flavonoids with Iron and Copper as a New Way of Decreasing the Oxidative Damage Induced by Transition Metal Supplementation	119	(4)
L. G. Korkina
E. A. Ostrachovich
G. A. Ibragimova
I. B. Afanas'ev
Oncogene Activation and Apoptosis as Possible Mechanism of Antitumour Effect of Ferric-Sorbitol-Citrate	123	(4)
Marija Poljak-Blazi
Marijeta Kralj
Marijana Popovic-Hadzija
Changes in Oxidant and Antioxidant Status in Rats Fed Different Amounts of Selenium and Exposed to NOx	127	(2)
J. Gromadzinska
W. Wasowicz
K. Rydzynski
J. Neve
Zinc Protects Genomic DNA from Solar Light Injury: A Possible Role for Zinc-Induced Metallothionein?	129	(2)
E. Jourdan
N. Emonet-Piccardi
A. Favier
J. C. Beani
M. J. Richard
The Effect of Carbamylation on Glutathione Peroxidase and Copper-Zinc Superoxide Dismutase	131	(2)
Heather E. Roxborough
Cheryl Reid
Jane McEneny
Caroline Mercer
Dorothy McMaster
Maireard O'Hare
Ian S. Young
Anthracyclin Resistance of GLC4 Tumoral Cells and Intracellular Selenium Metabolism	133	(2)
M. Andriollo
P. Guiraud
M. J. Richard
A. Favier
Antiproliferative Ability of Ferric-Sorbitol-Citrate and Ferrocenes for Malignant Cell Line, Hep2 and F10	135	(2)
M. Poljak-Blazi
A. Ferle Vidovic
V. Rapic
D. Skare
Modulation of SP1 and NFκB Binding Activity by Aluminum in HeLa Cells	137	(1)
C. Garrel
M. Osman
A. Favier
Antioxidant Micronutriments Insulin-Sensitivity	138	(1)
P. Faure
F. Couzy
D. Barclay
E. Rossini
M. J. Richard
J. Arnaud
A. Favier
S. Halimi
Exacerbated Immune Stress Response in Early Magnesium Deficiency in the Rat	139	(1)
A. Mazur
C. Malpuech-Brugere
W. Nowacki
E. Rock
Y. Rayssiguier
Zinc Protects Human Endothelial Vascular Cells against the Glucose Induced Cytotoxicity	140	(1)
K. Lalanne
S. Bouvard
N. Wiernsperger
P. Faure
A. Favier
S. Halimi
Effects of Elevated Dietary Cu and Cd Concentrations on Oxidative Stress, Cell Proliferation, and Apoptosis in Atlantic Salmon (Salmon Salar L.) Parr	141	(1)
Marc H. G. Berntssen
Sjoerd E. Wendelaar Bonga
Amund Maage
Modulation of Copper Deficiency Induced Oxidative Stress by Dietary Polyphenol in the Rat	142	(1)
I. Bureau
C. Feillet-Coudray
E. Gueux
E. Rock
A. Mazur
Y. Rayssiguier
Thioredoxin/Thioredoxin Reductase System: Their Roles in DNA Stability and Cell Adaptation to Ultraviolet Radiation	143	(1)
C. Didier
M.-J. Richard
J. C. Beani
A. Favier
Toxic Effect of Ciprofloxacin May be the Result of a Free Radical Pathway	144	(1)
A. Gurbay
B. Gonthier
D. Daveloose
F. Hincal
A. Favier
Transport, Speciation and distribution of Trace Elements
Trace Element Speciation in Human Body Fluids	145	(8)
Peter Bratter
Andrea Raab
Andrea N. Richarz
Gelfiltration and Anion-Exchange Chromatography for the Separation of Vanadium Binding Proteins in Plasma of Rats, Rabbits, and Humans	153	(4)
K. De Cremer
K. R. Cornelis
Metabolism of Selenate Administered into Rats: Speciation of Selenium by HPLC-ICP MS	157	(4)
Kazuo T. Suzuki
Yamato Shiobara
Fractionation of Soluble Selenium Compounds from Fish using Size-Exclusion Chromatography with On-Line Detection by Inductively Coupled Plasma Mass Spectrometry: Comparison with other Techniques	161	(4)
Gunilla Onning
Ingvar A. Bergdahl
Metabolism of Arsenic from Seaweed by Man and Animals: Speciation in Body Fluids using Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry	165	(4)
Jorg Feldmann
Speciation of Selenium in Food and Animal Feed using Ion Chromatography On-Line Microwave Pretreatment Hydride Generation Atomic Absorption Spectrometry	169	(4)
Magnus Johansson
Guy Bordin
Adela R. Rodriguez
Selenium True Absorption and Tissue Concentration of Rats at Dietary Selenite, Seleno Cysteine, and Seleno Methionine	173	(2)
W. Windisch
M. Kirchgeßner
Effects of Selenium Status on Selenium Incorporation into Plasma Fractions and Excretion in Urine in Men Infused with 74Se Selenite	175	(2)
Y. Xia
J. Butler
M. Janghorbani
P. Ha
P. Whanger
J. Olesik
L. Daniels
Magnesium Excretion and Redistribution in Rat Tissues after Disulfiram Experimental Administration	177	(1)
L. Kovatsi
M. Tsougas
H. Tsoukali
D. Psaroulis
Selenium and Arsenic Distribution in Soluble Protein Fractions in Liver of Hens Fed with Added As2O3	178	(2)
V. Stibilj
I. Falnoga
D. Cestnik
R. Jacimovic
Metal Distribution in Metallothioneins of Cytosols from Human Cirrhotic Livers	180	(1)
C. Wolf
P. Bratter
U. Rosick
Effect of Retinol Deficiency on Liver Concentration of Fe, Cr, Zn, Mn, Co, Cd, and Pb in Rat	181	(2)
A. C. Anzulovich
L. B. Oliveros
L. D. Martinez
M. Roura
M. S. Gimenez
Vitamin A Deficiency Modify the Antioxidant Defenses and the Trace Elements Level in Rat Liver	183	(1)
A. C. Anzulovich
L. Oliveros
D. Martinez
M. Baucells
M. S. Gimenez
Transport of Silver and Its Potential Interactions with Copper Metabolism in the Rat	184	(2)
S. Hanson
S. Donley
H. Rim
M. C. Linder
Dietary Vanadium, P-ATPase-7a Expression and the Influence on Lysyl Oxidase and Cu Accumulation in Rat Skin and Liver	186	(3)
Robert B. Rucker
Chang Tai Cui
Eskouhie H. Tchaparian
Alyson E. Mitchell
Michael Clegg
Janet Y. Uriu-Hare
Carl L. Keen
II. HUMAN PHYSIOLOGY AND STATUS OF TRACE ELEMENTS
Trace Elements in Food Chain, Diets and Intakes
Recommended Dietary Intakes for Trace Elements: New Trends	189	(6)
Janet C. King
Trace Element Addition to Foods: Technological and Nutritional Aspects	195	(6)
Denis Barclay
Trace Elements in Intravenous Nutrition	201	(8)
A. Shenkin
Trace Element Intake and Balance in Adults in Central Europe	209	(6)
M. Anke
M. Glei
W. Dorn
R. Muller
J. Vormann
M. Muller
M. Jahritz
M. Seifert
S. Holzinger
S. Drobner
B. Rohrig
C. Rother
L. Angelow
G. O. Latunde-Dada
Nutrient Risk Assessment: Implications for Food Fortification Policy	215	(6)
Mary R. L'Abbe
Kevin A. Cockell
Sheila Dubois
William H. Ross
Vanadium---An Essential Element for Animals and Humans?	221	(6)
M. Anke
H. Illing-Gunther
H. Gurtler
S. Holzinger
M. Jaritz
S. Anke
U. Schafer
Effect of Iron Fortification of Infant Weaning Foods on Mineral Absorption	227	(1)
C. Martinez
G. Lopez
G. Ros
T. Fox
S. J. Fairweather-Tait
An Approach to Assessing the Safety of Trace Element Supplementation	228	(1)
D. H. Shrimpton
Strontium Transfer in the Food Chain of Humans	229	(2)
M. Anke
M. Seifert
M. Jaritz
E. Losch
E. Hartmann
Content of the Mineral Elements in the Light Diets Used for Alimentation of the Pensioner House Residents in Warsaw	231	(1)
A. Klos
J. Bertrandt
Determination of Mineral Levels in Walnut Cultivars after Microwave Mineralisation	232	(1)
F. Lavedrine
A. Ravel
A. Villet
V. Ducros
J. Alary
Average Intake of Trace Elements in Military Food Services in France	233	(2)
P. Le Francois
D. Argaud
Use of Haem Iron Concentrate in the Fortification of Weaning Foods	235	(2)
C. Martinez
G. Ros
M. J. Periago
G. Lopez
Mineral Content in Four Spanish Fish after Bone Addition	237	(2)
Isabel Martinez
Maria Jesus Periago
Marina Santaella y Gaspar Ros
Trace Elements in Austrian Food	239	(1)
A. Sima
M. Wilplinger
S. Zochling
S. Heumann
U. Schaller
W. Pfannhauser
Trace Element (Cu, Fe, Zn) Intakes in Cuba	240	(2)
T. Verdura
J. Arnaud
P. Fleites
M. Chassagne
A. Favier
R. Perez-Cristia
J. Barnouin
Distribution of Trace Elements and Minerals in Pulp and Peel of Apples and of Persimmons	242	(2)
Z. Zachwieja
J. Piotrowicz
M. Folta
H. Barton
S. Gorinstein
M. Zemser
S. Traktenberg
Mineral Elements in the Diet Planned for Consumption for Residents of the Pensioner House in Warsaw	244	(1)
J. Bertrandt
A. Klos
Zinc is Scarce and Expensive	245	(2)
N. Darmon
A. Briend
Estimated Daily Intakes and Concentrations of Essential Trace Elements in Infant Formulas	247	(1)
I. Navarro
J. I. Alvarez
A. Martin
Clinical Evaluation of ``Designer Eggs'' as a Source of Essential Micronutrients for Humans	248	(2)
P. Surai
A. MacPherson
Plasma Levels of Selenium, Selenoprotein P, and Glutathione Peroxidase and Their Correlations to Fish Intake and Serum Levels of Thyropropin and Thyroid Hormones---A Study on Latvian Fish Consumers	250	(2)
L. Hagmar
M. Persson-Moschos
B. Akesson
A. Schutz
Interlaboratory Comparison Studies into Determination of Metals Content in Foods, Organized by the National Institute of Hygiene	252	(3)
Krystyna Starska
Maria Wojciechowska-Mazurek
Elzbieta Brulinska-Ostrowska
Kazimierz Karlowski
Trace Elements Bioavailability
Bioavailability of Trace Elements in Human Diet	255	(6)
Susan J. Fairweather-Tait
The Influence of Various Food Ingredients and Their Combinations on in Vitro Availability of Iron and Zinc in Cereal Based Vegetarian Meals	261	(6)
V. V. Agte
K. V. Tarwadi
S. A. Chiplonkar
Is Increasing Ascorbic Acid Intake from Foods an Effective Strategy for Improving Dietary Iron Bioavailability? An Evaluation Using Dietary Algorithms, Iron Isotopes, and a Food-Based Community Intervention Trial in Rural Mexico	267	(4)
Lindsay H. Allen
Olga Garcia Obregon
Margarita Diaz
Steven Abrams
Suzanne Murphy
Jorge L. Rosado
Iron Intake from Mixed Meals in Cameroon	271	(4)
A. Bell
F. Ndigui
P. Effa
Bioavailability of Calcium and Zinc from Various Infant Formulae with and without Thickening Agents	275	(4)
Douwina Bosscher
Kristien Van Dyck
Harry Robberecht
Micheline Van Caillie-Bertrand
Hendrik Deelstra
Absorption of Selenium from Biosynthetically Labelled Foods in Humans	279	(4)
C. Atherton
T. Fox
S. Fairweather-Tait
J. Dainty
J. Lewis
M. Baxter
H. Crews
N. Langford
Tissue Zinc Uptake as a Measure of the Relative Bioavailability of Supplemental Zinc Sources for Domestic Animals	283	(4)
C. B. Ammerman
M. Sandoval
P. R. Henry
R. C. Littell
R. D. Miles
Effects of Whole Wheat Flour and Fermentable Carbohydrates on Intestinal Absorption of Trace Elements in Rats	287	(6)
C. Coudray
H. W. Lopez
M. A. Levrat-Verny
J. Bellanger
C. Remesy
Y. Rayssiguier
Bioavailability of Different Sources of Protected Zinc	293	(6)
Daniel D. Gallaher
Cynthia M. Gallaher
Stephanie Shulman
Andrea McElhome
Kyle A. Brokken
Gerry Shurson
Cobalt Deficiency Induced Hyperhomocysteinemia and Oxidative Status of Cattle	299	(6)
G. I. Stangl
F. J. Schwarz
M. Kirchgessner
Role of Diet Related Habits and Cooking Practices on Bioavailability of Iron, Copper, and Zinc and Status of Iron in Vegetarians	305	(1)
V. V. Agte
M. Indumadhavi
V. Kakade
S. Palkar
S. Girigosavi
K. Tarwadi
S. A. Chiplonkar
Dialysability of Calcium, Iron, and Zinc in Beans, Chick Peas, and Lentils	306	(2)
V. Sebastia
R. Barbera
R. Farre
M. J. Lagarda
Effect of Zinc Depletion on Iron Transport across Isolated Duodenal Sacs	308	(1)
Peter W. F. Fischer
Bartholomeus Belonge
Mineral Element Status in Rats Fed Diets with Extruded or not Extruded Evening Primrose (Oenothera Paradoxa)	309	(2)
M. A. Gralak
H. Leontowicz
M. Leontowicz
A. Bogucka-Sciezynska
G. W. Kulasek
Combined Effects of Complex Carbohydrates and a Resistant Protein on Intestinal Absorption and Status of Iron and Zinc in the Rat	311	(2)
D. Grizard
C. Coudray
M. Tahiri
J. C. Tressol
Y. Van Doesum
Y. Rayssiguier
C. Barthomeuf
Nutrient Risk Assessment: Implications for Food Fortification Policy	313	(1)
Mary R. L'Abbe
Kevin A. Cockell
Sheila Dubois
William H. Ross
Design of Product as Source of Variance in ``in Vitro'' Mineral Availability of Homogenised Weaning Foods	314	(1)
A. B. Olivares
C. Martinez
G. Ros
Iron Dialysability in Enteral Diets	315	(2)
C. H. Azevedo
A. P. Galhardo
C. Colli
Trace Element Status
New Indices for Assessment of Trace Element Status and Requirement, with a Special Focus on Selenium	317	(6)
Jean Neve
Are Young Women with Low Iron Stores at Risk of Zinc as Well as Iron Deficiency?	323	(6)
R. S. Gibson
A-L Heath
N. Prosser
W. Parnell
U. M. Donovan
T. Green
K. E. McLaughlin
D. L. O'Connor
W. Bettger
C. M. Skeaff
Assessment of Femurs and Testis as Parameters for Zinc Bioavailability from Different Food Sources	329	(1)
G. S. Henriques
L. F. C. Pedrosa
E. L. Dantas
J. M. de Moura
C. L. Araujo
S. M. F. Cozzolino
The Effects of Low Protein Diet and Light Deprivation on Zinc Status and Gonad Function in Adult Male Rats	330	(1)
N. Virgona
M. Kamiyama
T. Yano
T. Esashi
Zinc Nutritional Status in Obese Children and Adolescents	331	(1)
D. N. Marreiro
M. Fisberg
S. M. F. Cozzolino
Reference Values of Selected Trace Elements in the Serum of Term Newborns from the Urban Area of Rome	332	(1)
Alessandro Alimonti
Francesco Petrucci
Francesco Laurenti
Sergio Caroli
Haptoglobin Polymorphism Association with Magnesium and Lipid Profile in Healthy Teenagers	333	(2)
M. Bicho
C. P. Monteiro
L. Sardinha
S. Llobet
P. Marques Vidal
M. J. Halpern
M. J. Laires
Urinary Lithium: Distribution Shape, Reference Values, and Evaluation of Exposure Based on Inductively Coupled Plasma Argon Emission Spectrometry	335	(1)
K. Usuda
K. Kono
T. Watanabe
T. Dote
H. Nishiura
M. Shimahara
N. Hashiguchi
H. Takeishi
Assessment of Nonheme Iron Status in the Whole Blood, Plasma, and Serum: Healthy Neonates and Patients with Iron Overload	336	(2)
O. M. Mykhaylyk
N. A. Dudchenko
T. A. Orlova
N. M. Pyasetska
I. P. Lubyanova
Lipid Peroxidation and Zinc and Copper Status in Healthy Adults after Ginseng Ingestion	338	(1)
A. Sanchez-Mayoral
R. De Miguel Romera
L. Perez Gallardo
Variability of Multiple Nutritional Elements in Hair of One Man Over Two Decades	339	(1)
L. M. Klevay
D. M. Christopherson
T. R. Shuler
Effect of Magnesium Deficiency on Enterocyte Ca, Fe, Cu, and Zn Content	340	(1)
E. Planells
N. Sanchez-Morito
P. Aranda
J. Llopis
Serum Copper, Zinc, and Selenium Levels with Regard to Psychological Stress in Men	341	(2)
A. Pizent
J. Jurasovic
M. Pavlovic
S. Telisman
Urinary Iodine and Thyroid Status of New Zealand Residents	343	(2)
C. D. Thomson
S. Woodruffe
A. Colls
T. D. Doyle
Serum Silicon Concentration of Healthy Persons in the Antwerp Region (Belgium)	345	(2)
K. Van Dyck
H. Robberecht
R. Van Cauwenbergh
H. Deelstra
Trace Elements in Pregnancy, Lactation, Growth
Zinc and Human Pregnancy	347	(6)
Michael Hambidge
Nancy Krebs
Laura Caulfield
Trace Element Nutrition during Pregnancy and Lactation---Effect on Milk Trace Elements	353	(6)
Bo Lonnerdal
Glutathione Peroxidase is Not a Functional Marker of Selenium Status in the Neonatal Period	359	(6)
L. A. Daniels
R. A. Gisbon
K. Simmer
Trace Element Transfer from the Mother to the Newborn---Investigations on Triplets of Colostrum, Maternal, and Umbilical Cord Sera	365	(4)
Michael Krachler
Erich Rossipal
Dusanka Micetic-Turk
Relationship between Trace Elements, Activities of Antioxidant Enzymes in Maternal and Umbilical Cord Blood in Poland	369	(4)
W. Wasowicz
J. Gromadzinska
K. Szram
K. Rydzynski
P. Wolkanin
Zb Pietrzak
J. Tomczak
Compensatory Changes in Selenoenzymes in Full Term Human Placentae Induced by Environmental Conditions	373	(2)
P. Zagrodzki
L. Zamorska
M. Zadrozna
Maternal Anemia at Delivery, Outcome of Pregnancy and Infant Birth Weight, in a Group of Low Socioeconomic Level, in Greater Buenos Aires	375	(2)
M. L. de Portela
L. Lopez
S. H. Langini
S. Fleischman
A. Weisstaub
M. Garcia
O. Moreno
C. R. Ortega Soler
Trace Element and Vitamin Deficiencies in French Pregnant Women	377	(2)
I. Hininger
M. Favier
H. Faure
J. Arnaud
F. Khatir
J. Thoulon
E. Hariveau
A. Favier
A. M. Roussel
Vinegar Drink to Improve Iron Status during Pregnancy	379	(2)
U. Heins
C. Koebnick
C. Leitzmann
Evolution of Copper Contents from Colostrum to Transitional Human Milk	381	(2)
M. D. Silvestre
M. J. Lagarda
R. Farre
C. Martinez-Costa
J. Brines
G. Clemente
Ceruloplasmin Oxidase Expression in the Rowett Hooded Rat and Human Placenta during Pregnancy	383	(2)
L. Gambling
W. Bruce-Johnson
R. G. Lea
M. J. Bingham
H. J. McArdle
Anemia and Its Therapy with Peroral Antianemics in Pregnancy and Puerperium	385	(2)
M. Mara
V. Eretova
J. Zivny
J. Kvasnicka
A. Umlaufova
E. Marova
Requirements for the Essential Trace Elements Iron and Zinc during Pregnancy	387	(1)
Shahla M. Wunderlich
Urinary Selenium in Preterm Infants: Effect of Inorganic Versus Organic Selenium Intake	388	(2)
L. A. Daniels
R. A. Gibson
K. Simmer
Trace Element Balance Study in Very Low Birthweight Infants	390	(1)
Andrea Raab
Andrea Loui
Peter Bratter
Michael Obladen
Nutritional Status of Iron of Pre-School Children from the City of Juiz de Fora, MG, Brazil	391	(2)
E. L. Chicourel
A. F. Pinto
Ae. C. Lassance
M. Fisberg
S. M. F. Cozzolino
Trace Elements in Exercise and Extreme Conditions
Exercise Effects on Trace Element Metabolism	393	(6)
Richard A. Anderson
Altitude Related Changes in Red Blood Cell Membrane Lipids and Proteins. Possible Links with Redox	399	(6)
Claus Behn
Manuel Ivan Estrada
Eliseo Hibert Davila
Oscar Araneda
Max Gonzalez
Alejandro Carrasco
Rudy Soria
Mauricio Araos
Mercedes Villena
Wilma Tellez
Hilde Spielvogel
Enrique Vargas
Jorge Cajigal
Gloria Celedan
Gustavo Gonzolez
Effect of Supplementation with Brazil Nuts (CP, Bertholletia excelsa H. B. R.), in Capoeira Players on Selenium (Se) Concentration and Glutathione Peroxidase's Activity (GSH-Px, E.C.1.11.1.9)	405	(2)
V. F. Coutinho
V. B. Bittencourt
S. M. F. Cozzolino
Effects of Weight Loss and Weight-Bearing Exercise on Blood and Organ Concentrations of Lead and Some Essential Metals	407	(2)
Francis W. Kemp
Shenggao Han
Wenjie Li
David Tiber
Chenzang Wang
David Sepulveda
Justin Holmes
John D. Bogden
Trace Elements in Aging
Trace Element Deficiencies and Supplementations in the Elderly	409	(8)
Anne-Marie Roussel
Serum and Urine Selenium Changes in a Group of Elderly during One Year of Selenium Supplementation	417	(4)
J. Kvicala
V. Zamrazil
J. Jiranek
Blood and Skin Antioxidant Status in Werner Syndrome (4 patients)	421	(4)
M. T. Leccia
M. J. Richard
G. Borla Darve
J. C. Beani
A. Favier
P. Amblard
Effects of Aluminum on Glutamate Metabolism: A Possible Explanation for Its Toxicity in the Aged Rats and in an Experimental Model of Aluminum Overload	425	(4)
Cecile Struys-Ponsar
Olivier Guillard
Phillippe van den Bosch de Aguilar
Zinc-Induced Excessive Glutamate Release May Cause Accelerated Senescence with Defect in Learning and Memory in Senescence Accelerated Mouse	429	(4)
Takeshi Saito
Noriko Nakagawa
Kyoko Takahashi
Dan Li
Yuwako Yamamoto
Hiroko Sasaki
Nozomu Nakamura
Kazuhiro Ogawa
Hiroyoshi Fujita
Masaaki Kurasaki
Masaski Okabe
Toshiyuki Hosokawa
Serum Selenium and Glutathione Peroxidase Activity in Octogenarian and Nonagenarian Subjects in Belfast	433	(4)
I. M. Rea
D. McMaster
A. Murphy
C. Mercer
Long Term Tropical Antioxidant Treatment Provides Protection against Clinical Signs of Photoaging	437	(4)
L. Vaillant
L. Declercq
D. Malvy
J. C. Beani
J. Bazex
D. Maes
S. Hercberg
Lactulose Stimulates Calcium Absorption in Postmenopausal Women Dose-Dependently	441	(1)
E. G. H. M. van den Heuvel
Th. Muijs
W. van Dokkum
G. Schaafsma
Selenium and Cognitive Decline in the Elderly---The EVA Study	442	(1)
C. Berr
B. Balansard
J. Arnaud
A. M. Roussel
A. Alperovitch
Does Hormonal Replacement Therapy Influence Antioxidant Status and LDL Oxidizability in Post-Menopausal Women?	443	(1)
I. Bureau
F. Laporte
V. Ducros
H. Faure
Y. Rayssiguier
A. Favier
A. M. Roussel
Metallothionein Expression and Its Significance in the Brain Aging of Dog	444	(2)
Akinori Shimada
Masahiko Satoh
Chiharu Tohyama
Vitamin and Mineral Intakes and Biochemical Status in a Spanish Aged Women Group. Effects of Body Mass Index	446	(2)
P. Valera
P. Garcia-Garcia
R. M. Ortega
A. Lopez-Sobaler
A. M. Requejo
Biomarkers of Mouse Aging: Modifications of Minerals and Antioxidant Enzymes	448	(1)
Heng-Kuan Wong
Jacqueline Riondel
Alain Favier
Does Hormonal Replacement Therapy Influence Trace Element Status in Post-Menopausal Women?	449	(1)
I. Bureau
J. Arnaud
R. Anderson
M. J. Richard
F. Laporte
A. Favier
A. M. Roussel
Relationship between Serum Selenium and Red Cell and Plasma Glutathion Peroxidase Levels: Effect of Supplementation with Nutritional Doses of Antioxidants in Elderly and Adult Subjects	450	(3)
Paul Preziosi
Josiane Arnaud
Marie-Jeanne Richard
Pilar Galan
Denis Malvy
Serge Briancon
Anne-Marie Roussel
Alain Favier
Serge Hercberg
Epidemiology of Trace Elements
Intervention Studies on Antioxidant Trace Elements. Special Focus on Selenium	453	(10)
Serge Hercberg
Selenium Status in Northern Ireland and France: The Prime Study	463	(4)
Dorothy McMaster
Pedro Marques-Vidal
Pierre Ducimetiere
Phillipe Amouyel
Dominique Arveiler
Alun Evans
Determinants of Blood Selenium Concentrations in France (SU VI MAX Study)	467	(2)
J. Arnaud
A. M. Roussel
P. Preziosi
P. Galan
S. Hercberg
A. Favier
Selenium Status and Antioxidant Enzyme Activities in High School Children from an Endemic Goiter Area	469	(2)
B. Giray
T. Tezic
Y. Gedik
A. Oktem
F. Hincal
Iodine Content of Water and Selenium Level in Corn and Wheat Consumed in an Endemic Goiter Area	471	(2)
B. Giray
F. Hincal
Selenium Deficiency in South-West Bohemia	473	(2)
J. Kvicala
V. Zamrazil
V. Jiranek
Effect of Copper Supplementation in Middle Aged People on Plasma Anti-Oxidants and Red Blood Cell Oxidizability: Foodcue Study	475	(2)
E. Rock
A. Mazur
Y. Rayssiguier
C. Kehoe
J. M. O'Connor
M. P. Bonham
J. J. Strain
Plasma and Urine Selenium of Cows from Various Regions of the Czech Republic and Its Comparison with Corresponding Human Population Selenium Indexes	477	(2)
J. Kvicala
V. Kroupova
A Comparative Study of Blood Antioxidant Parameters in Two Portuguese Urban Populations	479	(2)
A. M. Viegas-Crespo
M. C. Santos
M. L. Pavao
P. A. Lopes
J. Neve
Comparison of Trace Elements and Macronutrients in Breast Milk of Women from Eight Different Geographical Locations	481	(1)
G. M. Radzanowski
J. Jackson
K. Pramuk
S. M. Kaup
Selenium Concentration in Human Milk and the Daily Se Intake by Breast-Fed Infants in the Western Part of Poland	482	(2)
B. A. Zachara
A. Pilecki
Effect on Biochemical Markers of Two-Years Supplementation with Antioxidants in the SU.VI.MAX Study: Interest of Nutritional Doses	484	(2)
Serge Hercberg
Henri Faure
Paul Preziosi
Josiane Arnaud
Marie-Jeanne Richard
Pilar Galan
Denis Malvy
Serge Briancon
Anne-Marie Roussel
Alain Favier
Iodine Nutrition of French Adults Issued from the SU.VI.MAX Cohort	486	(2)
Pierre Valeix
Marjorie Zarebska
Paul Preziosi
Bruno Pelletier
Pilar Galan
Dietary Iron Intake and Iron Status of French Adults Participating in the SU.VI.MAX Cohort	488	(3)
Pilar Galan
Paul Preziosi
Bernadette Fieux
Marjorie Zarebska
Serge Briancon
Denis Malvy
Anne-Marie Roussel
Alain Favier
Serge Hercberg
III. Trace Elements in Human Diseases
Diabetes
Insulin Enhancing Effects of Vanadium	491	(6)
John H. McNeill
Is Zinc Essential to Modulate Insulin Sensitivity?	497	(6)
Patrice Faure
Serge Halimi Sophie Bouvard
Olivier Ramon
Karine Lalane
Anne Marie Roussel
Alain Emile Favier
Role of Chromium in Glucose Intolerance, Diabetes, Total Parenteral Nutrition, and Body Composition	503	(8)
Richard A. Anderson
William Cefalu
Khursheed N. Jeejeebhoy
Gilbert R. Kaats
Evaluation of Zinc in Children with Type 1 Diabetes Mellitus	511	(4)
L. P. C. Pedrosa
A. Spinola-Castro
M. Matsumoto
J. Len
F. Schwartzman
L. P. Camargo
S. M. F. Cozzolino
Zinc Sulphate Induced Metallothionein in Pancreatic Islets of Mice and Protected from Streptozotocin-Induced Diabetes	515	(4)
Patricia Ohly
Claudia Dohle
Josef Abel
Helga Gleichmann
Water Content of Minerals Associated with Type 2 Diabetes Mellitus of Samples Collected on the Navajo Reservation	519	(4)
Judith Hallfrisch
Claude Veillon
Kristine Patterson
A. David Hill
Irene Benn
Bessie Holiday
Ruby Ross
Sylvia Zhonnie
Frances Price
Ann Sorenson
Dietary Copper Deficiency Causes Elevation of Early and Advanced Glycation End-Products	523	(4)
J. T. Saari
G. M. Dahlen
The Use of Stable Isotope Tracers to Explorate Zinc and Selenium Metabolism in Insulin Dependent Patients	527	(1)
M. Bertouze
P. Faure
V. Ducros
S. Halimi
A. Favier
Zinc Modulates the Glucose Induced Rat Aortic Smooth Cell Proliferation	528	(2)
S. Bouvard
P. Faure
A. Favier
M. Leconte
S. Halimi
Metabolic Effects of Dietary Chromium-L-Methionine in Horses and Beef Cattle	530	(2)
M. T. Socha
S. L. Ralston
R. Raub
E. B. Kegley
C. K. Swenson
A. B. Johnson
T. M. Fakler
Zinc Protects HeLa Cells against the Glucose Induced Cytotoxic Effect	532	(2)
P. Faure
S. Bouvard
A. Favier
S. Halimi
Oxidative Stress and Antioxidant Trace Element Status in Patients with Non Insulin-Dependent Diabetes	534	(2)
A. Kerkeni
A. M. Roussel
A. Othmane
S. Majhoub
N. Zouari
F. Najjar
J. Arnaud
A. Favier
R. A. Anderson
Zinc Deficiency Increases the Deleterious Effect of High Fructose Diet on Fetal Development and Free Radical Activity in Rats	536	(2)
B. Lachil
P. Faure
C. Ribuot
J. Arnaud
M. J. Richard
M. Seve
A. Favier
Zinc 100 ppm Does Not Improve Insulin Sensitivity of High Fructose Fed Rats Leading to Insulin Resistance	538	(1)
E. Rossini
S. Bouvard
M. J. Richard
S. Halimi
A. Favier
Design of New Oxovanadium (IV) Complexes for Treatment of Diabetes. Bioavailability, Speciation, and Tissue Targeting Considerations	539	(1)
K. H. Thompson
J. H. McNeill
C. Orvig
The Metallic Component of the Glucose Tolerance Factor, G. T. F.: Cobalt against Chromium	540	(3)
F. Silio
A. Santos
B. Ribas
Cardiovascular Diseases and Oxidative Stress
The Interaction between Dietary Copper and Excess Iron---Increases the Risk of Heart Disease	543	(4)
Meira Fields
Charles G. Lewis
Selenium and Chronic Heart Failure	547	(4)
Michel de Lorgeril
Patricia Salen
Michele Accominotti
Antioxidant Status of Patients with Unstable Angina Pectoris and Acute Myocardial Infarction	551	(4)
Momcilo B. Mihailovic
Zorana Vasiljevic
Sladjana Sobajic
Ivan B. Jovanovic
Olivera Pesut
Gordana Matic
The Effect of Zinc Deficiency on Parameters of Lipoprotein Metabolism and Lipolysis in Rats Fed Different Fats	555	(4)
K. Eder
S. Wild
M. Kirchgessner
Plasma Level of Antioxidant Minerals (Cu, Zn, Mn, and Se) and Fe: A Comparison of Patients with Cerebro-vascular Disease and Healthy Adults in Korea	559	(4)
I. S. Kwun
H. S. Jang
C. S. Kwon
Trace Elements as Determined by ICP-MS Analysis in Patients with Coronary Artery Disease	563	(2)
Ellen Burgess
Robert Audette
Merril Knudtson
George Wyse
The Effect of Zinc Deficiency on Some Key Enzymes of Lipid Metabolism in Rats Fed Olive Oil or Linseed Oil	565	(1)
K. Eder
K. Waldhauser
M. Kirchgessner
Lipid Concentrations of Low-Density Lipoproteins and Their Oxidative Susceptibility in Zinc-Deficient Rats	566	(2)
K. Eder
M. Kirchgessner
Comparative Evaluation of Trace Elements Contents in Aortic Wall and in Hair Samples of Young Males	568	(1)
A. V. Skalny
A. A. Zhavoronkov
A. L. Chernyaev
A. V. Koudrine
Heart Disease Risk in the UK as Influenced by Environmental Factors and Defined by Hair Calcium Concentration	569	(2)
A. MacPherson
J. Bacso
Regulation of Hepatic Cholesterol and Lipoprotein Metabolism in Copper-Deficient Rats	571	(2)
A. Mazur
C. Serougne
C. Moundras
B. Bayle
F. Millat
Y. Rayssiguier
Copper Body Status and Cardiovascular Diseases	573	(1)
G. Mielcarz
Increased Plasma Glutathione Peroxidase Activity in Patients with Acute Myocardial Infarction	574	(1)
B. A. Zachara
M. Ukleja-Adamowicz
J. Lecka
E. Nartowicz
Other Human Diseases
Selenium in Cancer Prevention	575	(6)
M. P. Rayman
L. C. Clark
Trace Elements in Hypertension	581	(6)
Gianfranco Vivoli
Margherita Bergomi
Paola Borella
Sergio Rovesti
Persistence of Goiter Despite Oral Iodine Supplementation in Goitrous Children with Iron-Deficiency Anemia in the Cote d'Ivoire	587	(4)
Michael Zimmermann
Pierre Adou
Toni Torresani
Christophe Zeder
Richard Hurrell
Trace Elements in Patients Treated by On-Line Hemodiafiltration. The Blood Chromium Behaviour	591	(6)
A. Baj
G. Bregante
R. D'Angelo
G. Bonforte
F. Toffoletto
M. Surian
Relationships between Trace Element Nutriture and Progression of Human Immunodeficiency Virus Infection	597	(4)
John D. Bogden
Joan H. Skurnick
Francis W. Kemp
Shenggao Han
Joan Lloyd
Herman Baker
Donald B. Louria
Iron and Manganese Homeostasis in Chronic Liver Disease: Relationship to Pallidal T1-Weighted Magnetic Resonance Signal Hyperintensity	601	(6)
Elise A. Malecki
Attila G. Devenyi
Todd F. Barron
Timothy J. Mosher
Paul Eslinger
Claire V. Flaherty-Craig
Lorenzo Rossaro
Effect of Depression and of Antidepressant Therapy on Serum Zinc Levels---A Preliminary Clinical Study	607	(4)
Malgorzata Schlegel-Zawadzka
Andrzej Zieba
Dominika Dudek
Miroslaw Krosniak
Maria Szymaczek
Gabriel Nowak
Abnormalities of Iron Homeostasis in the Pregnancy Syndrome Pre-Eclampsia	611	(6)
M. P. Rayman
J. Barlis
S. Sokari
R. W. Evans
C. W. G. Redman
L. J. King
Lipid Peroxidation in Patients with Diseases Known to Affect Trace Element Status	617	(6)
Mariana Vlad
P. J. Porr
G. Uza
Maria Zirbo
Selenium Status of Breast and Gastroinstestinal Cancer Patients in Turkey	623	(2)
B. Avsar
I. G. Gokmen
Zinc and Selenium Intake in Nondialysed Patients with Chronic Renal Failure	625	(1)
D. Mafra
D. I. T. Favaro
S. M. F. Cozzolino
Zinc Nutritional Status in Patients with Chronic Renal Failure, Residents in Sao Paulo, Brazil	626	(1)
D. Mafra
L. Cuppari
S. M. F. Cozzolino
Iron, Zinc, Copper Levels of Thalassemia Patients of Northern Cyprus	627	(2)
R. Oktekin
G. Gokmen
Blood Markers of Oxidative Stress in Patients with Amyotrophic Lateral Sclerosis	629	(2)
D. Bonnefont-Rousselot
M. C. Jaudon
L. Lacomblez
B. Bourely
V. Doppler
C. Bizard
F. Salachas
G. Bensimon
J. Delattre
V. Meininger
Glutathione Peroxidase Activity Is Reduced in Haemodialysis Patients	631	(2)
H. E. Roxborough
C. M. Loughrey
C. Mercer
D. McMaster
I. S. Young
Copper and Zinc Levels in Patients with Colorectal Polyps	633	(1)
K. Linke
G. Mielcarz
K. Zietek
Total Superoxide Dismutase Activity and Glutathione Peroxidase Activity in Plasma of Phenylketonuric Subjects Supplemented with Selenium	634	(2)
M. Calomme
P. Cos
V. Ramaekers
B. Francois
M. Van Caillie-Bertrand
D. Vanden Berghe
The Content of Selected Bioelements in Hair of Children with Infantile Cerebral Palsy (Paralysis Cerebralis Infantilis, Diplegia)	636	(2)
R. W. Wojciak
Z. Krejpcio
Serum Copper in Juvenile Rheumatoid Arthritis	638	(1)
O. M. S. Amancio
D. M. A. Chaud
M. O. E. Hilario
Serum Copper in Juvenile Rheumatoid Arthritis: Influence of Dietary Copper	639	(1)
D. M. A. Chaud
O. M. S. Amancio
Hilario M. O. E.
Gallium Nitrate and Zinc Content in Peripheral Blood Lymphocytes of Patients with Lung Cancer	640	(1)
A. V. Koudrine
A. V. Skalny
Antioxidant Systems in Normal and Preeclamptic Algerian Pregnant Women	641	(2)
Brahim Lachili
Josiane Arnaud
Henri Faure
Marie Jeanne Richard
Anwar Bouabsa
Anne Marie Roussel
Alain Favier
Effect of Erythropoietin Therapy and Selenium Supplementation on Some Antioxidant Parameters in Blood of Uremic Patients on Long-Term Hemodialysis	643	(2)
B. A. Zachara
A. Adamowicz
U. Trafikowska
A. Pilecki
A. Trafikowska
E. Nartowicz
J. Manitius
Trace Element Toxicity and Environmental Exposure
Arsenic Groundwater Contamination and Sufferings of People in West Bengal-India and Bangladesh	645	(6)
U. K. Chowdhury
B. K. Biswas
T. Roy Chowdhury
B. K. Mandal
G. Samanta
G. K. Basu
C. R. Chanda
D. Lodh
K. C. Saha
D. Chakraborti
S. C. Mukherjee
S. Roy
S. Kabir
Q. Quamruzzaman
Heavy Metals and Persistent Organic Pollutants in Newborn Correlated with Maternal Smoking	651	(4)
Bente Deutch
Jens C. Hansen
Copper and Early Childhood Cirrhosis (ECC)---A Retrospective Study in Germany	655	(8)
H. H. Dieter
W. Schimmelpfenning
E. Meyer
M. Tabert
Difference in Penetration of Metals into the Brain	663	(4)
Takeshi Minami
Yuko Sakita
Yuko Okazaki
Ryouhei Amano
Exposure to Platinum-Group Metals Released by Automotive Catalytic Converters: The Case of Urban Youngsters	667	(4)
S. Caroli
F. Petrucci
B. Bocca
M. Krachler
F. Forastiere
A. Alimonti
Urinary Copper and Mortality among Inhabitants Living in a Cadmium Polluted Area in Japan	671	(4)
M. Nishijo
H. Nakagawa
Y. Morikawa
M. Tabata
K. Miura
K. Higashiguchi
T. Seto
T. Kido
K. Nogawa
K. Mizukoshi
M. Nishi
Serum Selenium in Relation to Biomarkers of Lead in Men	675	(4)
J. Jurasovic
A. Pizent
S. Telisman
Hepatotoxic Effects Associated to Short and Long Term Exposure to Excess Dietary Copper in Rats	679	(6)
E. Aburto
A. Cribb
C. Fuentealba
The Biological and Medical Importance of the Interactions between Nickel and Zinc, Magnesium and Manganese in Vivo	685	(2)
M. Anke
A. Trupschuch
G. Gunstheimer
Effect of Aluminum on Manganese Superoxide Dismutase (MnSOD) Expression	687	(1)
C. Garrel
C. Carron
A. Favier
Indicators for Sensitisation to Ni, Co, and Cr, a Eu-Project	688	(2)
Olof Vesterberg
Fish Consumption and Mercury Speciation in Hair of Indigenous Population of the Amazon	690	(1)
Antonio C. Barbosa
Jose G. Dorea
Jurandir R. Souza
Glauce L. Oliveira
Metabolism of Phospholipids in Pituitary Gland: Effect of Ion Cadmium	691	(2)
Ana Maria Calderoni
Maria Sofia Gimenez
Investigations on the Elements Status Markers in Humans. Lead Significant Correlation between Pb Content in Milk Teeth and Blood of 6-Year-Old Children	693	(2)
H. Barton
Z. Zachwieja
M. Folta
Morphologic and Biochemical Assessment of the Role of Lipid Peroxidation in the Pathogenesis of Copper Toxicity in Copper-Loaded Rats	695	(2)
E. Aburto
A. Cribb
I. C. Fuentealba
Effect of Dolomite and Thiamine Supplementation on Tissue Trace Elements Concentrations in Lead-Intoxicated Rats	697	(2)
Z. Krejpcio
D. Olejnik
R. W. Wojciak
J. Gawecki
Acute Human Molybdenum Toxicity from a Dietary Molybdenum Supplement---A New Member of the ``Lucor Metallicum'' Family	699	(2)
Berislav Momcilovic
Effects of Lead on the Maturation of the Female Gamete and Fertility	701	(2)
B. Lefevre
J. Poupon
A. Pesty
V. Machelon
J. Testart
Rhamnogalacturonan II (RG-II), a Prectic Polysaccharide Present in the Vegetable-Derived Products, Strongly Decreases Lead Tissue Accumulation: Potential Interest in Chronic Lead Exposure	703	(2)
M. Tahiri
P. Pellerin
J. C. Tressol
T. Doco
Y. Rayssiguier
C. Coudray
Dietary Exposures to the Platinum Group Elements	705	(2)
G. E. Ysart
P. F. Miller
H. Crews
P. Robb
M. Baxter
C. De L'argy
S. Lofthouse
C. Sargent
N. Harrison
Acute and Chronic Effects of Acid Phenol Compounds on Aluminum Retention in Rats	707	(2)
Z. Deng
L. Gouzoux
C. Coudray
A. Mazur
Y. Rayssiguier
D. Pepin
Determination of Total and Soluble Titanium in Soft Tissues Covering Titanium Microplates in Stomatology: An Analytical Study	709	(2)
J. Poupon
J. P. Meningaud
C. Chenevier
M. Galliot-Guilley
J. Ch. Bertrand
IV. TRACE ELEMENTS IN ANIMALS
Tissue Selenium Levels in Laying Hens Are Influenced by Dietary Oils and Fatty Acids Including Trans Fatty Acids	711	(6)
Klaus Schafer
Dietary Mo as an Antagonist to Cu Absorption: Stable Isotope (65Cu) Measurements in Grazing Sheep	717	(6)
S. O. Knowles
N. D. Grace
J. R. Rounce
A. Litherland
D. M. West
J. Lee
Copper-Associated Cirrhosis in North Ronaldsay Sheep: A Possible Model for Idiopathic Copper Toxicosis	723	(6)
S. Haywood
T. Muller
W. Muller
Z. Dincer
Dietary Copper Affects Lipid and Cholesterol Metabolism in Finishing Steers	729	(4)
T. E. Engle
J. W. Spears
C. L. Wright
T. A. Armstrong
A Comparison of Two Methods of Copper Supplementation for Grazing Red Deer (Cervus Elaphus)	733	(4)
D. V. Illingworth
D. W. Jackson
N. R. Kendall
S. B. Telfer
Trace Elements and Vitamins in Blood of Alpacas (Lama pacos) and Sheep Grazing the Same Pasture	737	(4)
G. J. Judson
B. A. McGregor
A. M. Howse
A Comparison of the Efficacy of Proprietary Products in the Treatment of Molybdenum Induced Copper Deficiency	741	(8)
N. R. Kendall
C. Middlemas
H. Maxwell
F. Birch
D. V. Illingworth
D. W. Jackson
S. B. Telfer
The Effect of a Copper, Cobalt, and Selenium Bolus on Sheep from Three Upland Scottish Farms	749	(4)
A. M. Mackenzie
N. R. Kendall
D. V. Illingworth
D. W. Jackson
I. M. Gill
S. B. Telfer
Selenium and Fluoride Toxicology---Water Quality Guidelines for Dohne Merino Sheep in Southern Africa	753	(6)
J. A. Meyer
N. H. Casey
Effect of Dietary Copper Level and High Sulfate Water on Copper Metabolism and Growth in Cattle	759	(4)
C. L. Wright
J. W. Spears
T. E. Engle
T. A. Armstrong
Apparent Trace Element Absorption in Growing Pigs Fed Rations of Increasing Calcium Carbonate Content	763	(4)
Torben Larsen
Jose A. Fernandez
Ricarda M. Engberg
Heat Processing of Protein Sources on the Faecal Excretion of Their Selenium in Dairy Cows	767	(1)
J. B. J. van Ryssen
G. E. Schroeder
Dietary Antagonists to Copper Absorption: Stable Isotope Measurements in Grazing Ruminants	768	(1)
J. Lee
N. D. Grace
J. R. Rounce
S. O. Knowles
The Effect of a Zinc, Cobalt, and Selenium Bolus on Ram Semen Quality and Trace Element Status	769	(3)
N. R. Kendall
A. Green
S. McMullen
R. G. Rodway
The Effect of Lead on the Rate of Fermentation of Herbage by Rumen Micro-Organisms	772	(3)
S. T. Strojan
C. J. C. Phillips
Effects of Intraruminal Monensin and Selenium Capsules on Glutathion Peroxidase, Calcaemia, Phosphatemia, and Live Weight Gain in Heifers on Pasture with Solanum Malacoxylon	775	(2)
Bruna E. Ruksan
Laura Marangunich
L. Barry Lowe
Trace Element Content in Natural and Commercial Cat's Food and Trace Element Status of Cats Depending on Sex and Disease	777	(2)
S. Anke
H. Gurtler
M. Anke
Validation and Normal Ranges of Plasma Ceruloplasmin Concentration in Cats and Dogs	779	(2)
C. J. Charlton
S. L. Wattam
N. D. Skinner
Current AAFCO and NRC Recommendations for Selenium Are Too Low for Puppies	781	(1)
K. J. Wedekind
J. DeBraekeleer
G. F. Combs
The Effect of a Zinc, Cobalt, and Selenium Bolus on Sheep from Nine Upland Scottish Farms	782	(2)
N. R. Kendall
A. M. Mackenzie
D. V. Illingworth
D. W. Jackson
I. M. Gill
S. B. Telfer
Field Trials of A Copper, Cobalt, and Selenium Soluble Glass Bolus	784	(2)
N. R. Kendall
A. M. Mackenzie
S. B. Telfer
Evaluation of the Trace Mineral Status of Lactating Dairy Cattle in Trans NZOIA District Western Kenya	786	(1)
F. D. O. Oduor
I. O. Jumba
S. O. Wandiga
Canine Ferritin: Assay Validation and Normal Range for Serum	787	(2)
N. D. Skinner
C. J. Charlton
S. L. Ebbrell
V. INDIVIDUAL TRACE ELEMENTS
Iron
Iron in Infancy: Absorption, Erythrocyte Incorporation, Loss	789	(6)
Robert E. Serfass
Transport of Iron in Health and Diseases	795	(4)
Andreas Rolfs
Matthias A. Hediger
Benefits and Problems Associated with Iron Supplementation and Fortification	799	(10)
Serge Hercberg
Low Iron Diet and Cadmium Exposure Disrupt Steroidogenesis in the Rat	809	(4)
Martina Piasek
John W. Laskey
Krista Kostial
Maja Blanusa
Janet M. Ferrell
Peculiarities of Nonheme Iron Metabolism upon Experimental Modelling of Rat Glial Brain Tumour. Perspectives for Diagnosis and Treatment	813	(6)
Olga M. Mykhaylyk
Natalie A. Dudchenko
Eugene A. Lebedev
Bogdan S. Shurunov
Iron Bioavailability from Iron Amino Acid Chelate or Ferrous Sulfate for Treatment of Iron Deficiency Anemia	819	(1)
Oscar Pineda
H. DeWayne Ashmead
Alain Bourdonnais
The Effect of a High Intake of Whole Wheat Bread Produced with and without Phytase on Iron Status in Young Women	820	(1)
M. Hansen
B. A. Jorgensen
S. Sandstrom
Zinc Status in Pregnancy Assessed by Hair Analysis---Nutritional Influences	821	(2)
U. Heins
C. Koebnick
C. Leitzmann
In Vitro Properties of Ferrous and Ferric Ions with Phytate	823	(2)
D. Oberleas
Iron Metabolism in Rats Consuming Olive Oil or Sunflower Oil Unused or Used in Repeated Potato Frying	825	(2)
A. M. Perez-Granados
M. P. Vaquero
M. P. Navarro
The Ferritin Secreted by Cultured Hepatoma Cells in Response to Iron and Inflammatory Cytokines Strongly Resembles the Ferritin in Serum and Has Homology to Intracellular Ferritins as Well as Immunoglobulins	827	(2)
L. Butcher
M. Hazegh-Azam
A. Nguyen
P. Nguyen
K. Vu
L. Rezaee
C. Juska
K. Schaffer
M. Zamany
L. Estevez
M. Hallock
M. C. Linder
Two Levels of Iron Supplementation and Developmental Outcome, Iron Nutrition, and Adverse Results in Low Birth Weight Infants	829	(2)
J. K. Friel
P. F. Kwa
B. Simmons
K. Aziz
C. Mercer
A. MacDonald
W. L. Andrews
Selenium
Some Functions of the Essential Trace Element, Selenium	831	(6)
Thressa C. Stadtman
Characteristics and Function of Selenoprotein P	837	(6)
Raymond F. Burk
Kristina E. Hill
Some Biochemical Functions of Selenium in Animals and Man	843	(6)
J. R. Arthur
G. J. Beckett
The Secis Element in Selenoprotein mRNAS. A Rosetta Stone for Decoding the UGA Selenocysteine Codon and a Molecular Tag for Unveiling New Selenoproteins	849	(6)
Alain Lescure
Daniel Gautheret
Robert Walczak
Philippe Carbon
Alain Krol
Prolonged Stimulation of Rats with Adrenocorticotrophic Hormone (ACTH) Alters Concentration of Selenium in the Kidney: Reversibility and Possible Mechanism	855	(4)
B. Cheng
T. S. Srikumar
F. M. Al-Awadi
J. Thakkar
F. Sequeira
Dietary Selenium Intake and Antioxidant Defenses in Tissues of Peripuberal Rats	859	(6)
Maria Cristina Santos
Jean Neve
Maria Leonor Pavao
Ana Maria Viegas-Crespo
Selenoprotein P in Plasma in Relation to Cancer Morbidity in Middle-Aged Swedish Men	865	(4)
Marie Persson-Moschos
Lars Stavenow
Bjorn Akesson
Folke Lindgarde
Effect of Selenium Supplementation on Plasma Selenoprotein P of New Zealanders	869	(4)
Christine D. Thomson
Anna J. Duffield
Kristina E. Hill
Tracking the Metabolism and Excretion of Selenium in Real Time in Humans	873	(4)
G. Bellisola
M. Colombatti
G. Fracasso
F. Pasti
M. Valdes
A. Torboli
Changes in Indices of Selenium Status in Men on Low, Medium, and High Intakes	877	(6)
T. Fox
C. Atherton
S. Fairweather-Tait
J. Dainty
J. Lewis
M. Baxter
H. Crews
True Absorption, Excretion, and Tissue Retention of Selenium at Widely Varying Selenium Supply to Rats	883	(4)
W. Windisch
M. Kirchgessner
The Oral Intake of Antioxidant Nutrient Associated with Selenium Does Protect Skin against Actinic Exposure	887	(4)
Jean Pierre Cesarini
S. Demanneville
Bioavailability of Selenium from Untreated and Processed Selenomethionine-Enriched Fillets of Atlantic Salmon (Salmosalar)	891	(1)
R. Oernsrud
M. Lorentzen
Stability of Glutathione Peroxidase Activity during Storage and Heat Treatment of Whey	892	(1)
H. Lindmark Mansson
J. Chen
B. Akesson
Purification and Enzyme-Linked Immunoassay of Bovine Extracellular Glutathione Peroxidase	893	(2)
H. Lindmark Mansson
B. Akesson
Selenium Distribution in Liver of Hens Fed with Sunflower Oil	895	(2)
I. Falnoga
V. Stibilj
D. Mazej
M. Tusek Znidaric
Selenium and Lipoproteins: Preliminary in Vivo and in Vitro Observations in Humans	897	(2)
V. Ducros
F. Laporte
N. Belin
A. David
A.-M. Roussel
A. Favier
Transforming Growth Factor-β1 Inhibits Selenoprotein P Expression in Cultured Human Liver Cells	899	(2)
V. Mostert
I. Dreher
J. Kohrle
J. Abel
Experimentally Induced Selenium and Vitamin E Deficiency in Growing Rabbits	901	(2)
J. Pallauf
A. Muller
Erika Most
Identification of 5 Novel Selenoproteins Based on RNA Structural Tags	903	(1)
A. Lescure
D. Gautheret
P. Carbon
A. Krol
Tat Protein of HIV1 Decreases Selenoglutathione Peroxidase and Increases Uv-A Cytotoxicity Independently of Selenium Supplementation	904	(2)
M. J. Richard
P. Guiraud
A. Favier
Serum Selenium Concentrations and the Acute Phase Response	906	(3)
T. M. T. Sheehan
Aleha Khatun
Copper
Neurochemical Alterations following Perinatal Copper Deficiency in Rodents	909	(8)
Joseph R. Prohaska
Molecular Analysis of Wilson Disease Gene in French Patients	917	(6)
I. Ceballos-Picot
A. Nicole
B. Aral
C. Franvel
C. Soulie
H. Lassal
F. Woimant
M. Haguenau
P. Chappuis
Defining Optimal Copper Status in Humans: Concepts and Problems	923	(6)
J. J. Strain
Dietary Copper, Vanadate, Lysyl Oxidase Activity, and Lysine Tyrosyl Quinone Formation	929	(4)
Robert B. Rucker
Changtai Cui
Eskouhie H. Tchaparian
Alyson E. Mitchell
Michael Clegg
Janet Y. Uriu-Hare
Brian Rucker
Tracy Stites
Carl L. Keen
Copper Metabolism in the Rodent Kidneys	933	(4)
Masaaki Kurasaki
Masashi Okabe
Mika Suzuki-Kurasaki
Shigeru Saito
Toshiyuki Hosokawa
Osamu Yamanoshita
Takeshi Saito
Effect of Copper in the Food Chain on Human Health (FOODCUE: Fair Ct95-0813)	937	(6)
E. Rock
J. J. Strain
J. M. O'Connor
M. P. Bonham
Y. Rayssiguier
A. Mazur
B. Sandstrom
S. Hodjberg-Bugel
S. J. Fairweather-Tait
I. J. Harvey
G. Majsak-Newman
A. Flynn
K. Cashman
A. Baker
F. Ginty
J. H. Beattie
I. Bremner
M. D. Reid
G. Rotilio
M.-L. Scarino
Y. Sambuy
S. Ferruzza
M. R. Ciriolo
A. DeMartino
The Effect of Copper Supplementation on Putative Indices of Body Copper Status and on Oxidative and Inflammatory Measures (FOODCUE Project)	943	(4)
J. M. O'Connor
M. P. Bonham
E. Turley
C. Kehoe
J. S. Coulter
M. S. Faughnan
A. McKeown
V. J. McKelvey-Martin
E. Rock
Y. Rayssiguier
A. Mazur
A. Flynn
K. Cashman
A. Baker
J. J. Strain
Role of Ceruloplasmin in Fe Efflux from Placenta; Identification of an Endogenous Cu Oxidase in Human Placental Cells (BeWo)	947	(4)
Ruth Danzeisen
Harry J. McArdle
Dietary Molybdenum: Effect on Copper Absorption, Excretion, and Status in Young Men	951	(4)
Judith R. Turnlund
William R. Keyes
Identity and Regulation of the Copper Transport Protein, Transcuprein	955	(2)
N. Liu
L. Lo
T. Tran
L. Jones
M. C. Linder
Response of Diamine Oxidase and Other Copper Status Biomarkers to Modifications in Dietary Copper in the Rat	957	(2)
C. Feillet-Coudray
A. Mazur
C. Coudray
E. Rock
Y. Rayssiguier
Effect of Dietary Copper Intake on Biochemical Indices Associated with Copper Metabolism	959	(2)
L. Harvey
G. Majsak-Newman
S. Fairweather-Tait
A. Baker
K. Cashman
A. Flynn
Zinc
Metallothioneins: Their Cellular Function and Relationship with Zinc	961	(8)
John H. Beattie
Ian Bremner
Zinc as a Cellular Regulator of Apoptosis	969	(8)
Alain Favier
Zinc and Growth	977	(4)
Michael Hambidge
Nancy Krebs
Zinc Nutriture as Related to Brain	981	(6)
Harold H. Sandstead
Christopher J. Frederickson
James G. Penland
Zinc in Preterm and Term Infants---Parallel Studies on Metabolic Balances and Plasma Concentrations	987	(4)
E. Sievers
U. Schleyerbach
T. Arpe
D. Garbe-Schonberg
J. Schaub
Activity of Calmodulin-Regulated Enzymes in Tissues of Zinc-Deficient Rats	991	(4)
H.-P. Roth
S. Schmidmayer
M. Kirchgessner
Zinquin Ester---A Reagent for the Investigation of the Role of Available Zn(II) in Living Systems	995	(4)
David Ward
Stephen Lincoln
Henry Betts
Peter Zalewski
Ian Forbes
Indumathy Mahadevan
Marc Kimber
Kym Hendrickson
Cognitive Effects of Adaptation to a Low Zinc Diet in Healthy Men	999	(4)
M. J. Kretsch
A. K. H. Fong
J. G. Penland
B. Sutherland
J. C. King
Intracellular Zinc Chelation Induces Apoptosis, Caspases Activation, and Transcription Factors Degradation in Jurkat and HeLa Cells	1003	(6)
Seve Michel
Chimienti Fabrice
Richard Sandrine
Mathieu Jacques
Favier Alain
Effect of Zinc Supplementation on Biological Parameters of Bone Turnover in Healthy Men	1009	(4)
Anne Peretz
Pierre Bergmann
Theodore Papadopoulos
Vania Siderova
Jean Neve
Betaine-Homocysteine S-Methyltransferase is an Abundant Zinc Metalloenzyme in Liver	1013	(4)
Andrew P. Breska III
Timothy A. Garrow
Nourishment: To Moderate Constantly or to Indulge Occasionally---The Message of Zinc Dose-Rate Idiorrhythm to the Needy	1017	(4)
Berislav Momcilovic
Concentration of Growth Hormone, IGF-1, Insulin and C-Peptide in Rat Serum during Development of Alimentary Zinc Deficiency	1021	(4)
H.-P. Roth
M. Kirchgessner
Moderately High Zinc Intake Impairs Verbal Memory of Healthy Postmenopausal Women on a Low Copper Diet	1025	(6)
James G. Penland
David B. Milne
Cindy W. Davis
Identification of the Zinc Binding Protein in a Child with Hyperzincaemia as Calprotectin (MRP8/MRP14)	1031	(4)
B. Sampson
P. Richmond
B. E. Golden
M. K. Fagerhol
J. H. Beattie
I. Z. Kovar
Characterisation of the Different Steps during Zinc Chelation Induced Apoptosis in Jurkat and HeLa Cells	1035	(1)
F. Chimienti
M. Seve
S. Richard
J. Mathieu
A. Favier
Effect of Ion Zinc on the Metabolism of Phosphatidylcholine and Sphingomielin in Lung of Rat	1036	(2)
N. N. Gomez
M. R. Fernandez
M. S. Ojeda
M. S. Gimenez
Metallothionein, Calmodulin, and Trace Elements in Healing Skin Wounds	1038	(1)
B. Sampson
A. Lansdown
A. Rowe
Zinc Modulation of Macrophages Interleukin 1 Gene Expression and Secretion	1039	(1)
A. E. Aguilar
R. Pastelin
S. Perez
M. D. Lastra
Assessment of Zn Role in Murine Experimental Cysticercosis Caused by Taenia crassiceps	1040	(3)
M. D. Lastra
E. Sciutto
R. Pastelin
A. E. Aguilar
G. Fragoso
Boron
The Dogged Path to Acceptance of Boron as a Nutritionally Important Mineral Element	1043	(6)
Forrest H. Nielsen
Homing in on the Molecular Basis of Boron Essentiality Using Differential Display, Gene Arrays, and Northern Blots	1049	(4)
C. D. Eckhert
A. Bennett
K. Becker
D. Luo
Estimation of Dietary Boron Intake in Six Countries: Egypt, Germany, Great Britain, Kenya, Mexico, and the United States	1053	(4)
Charlene Rainey
Leslie Nyquist
Jennifer Casterline
Dena Herman
Nutritional Essentiality of Boron for Development, Maturation, and Reproduction in Frogs---A Review	1057	(4)
D. J. Fort
R. L. Rogers
E. L. Stover
P. L. Strong
F. J. Murray
Effects of Boron in Wound Healing: Experiments on Nude Mice	1061	(6)
Brigitte Dousset
Mohamed Benderdour
Ketsia Hess
Rosine Mayap-Nzietchueng
Francine Belleville
Andre Duprez
Effect of Dietary Boron on Bone Characteristics and Plasma Parameters in Young Pigs	1067	(4)
T. A. Armstrong
J. W. Spears
T. E. Engle
C. L. Wright
Dietary Boron Is a Physiological Regulator of the Normal Inflammatory Response	1071	(6)
Curtiss D. Hunt
Boron Stimulated Yeast Differential Gene Expression	1077	(1)
A. Bennett
V. Gilman
N. Soch
D. Luo
C. D. Eckhert
Identification by Gene Arrays of Boron Responsive Genes in Yeast	1078	(1)
K. Becker
A. Bennett
C. D. Eckhert
Limb Teratogenesis Induced by Chronic Boron or Copper Deficiency in Xenopus	1079	(1)
D. J. Fort
E. L. Stover
F. J. Murray
P. L. Strong
An Assessment of Fertility in Boron-Exposed Turkish Subpopulations: An Epidemiological Approach	1080	(2)
M. Col
B. S. Sayli
Y. Genc
E. Ercevik
A. H. Elhan
A. Keklik
Photoreceptor Dystrophy in Boron Depleted Zebrafish	1082	(1)
S. Dohs
C. D. Eckhert
Adverse in Vitro Development of Preimplantation Mouse Embryos Exposed to Low Boron Diet and Low Boron	1083	(2)
L. Lanoue
F. J. Murray
P. L. Strong
C. L. Keen
The Temporal Effects of Low Dietary Boron (B) on Tissue B Concentrations in Rats	1085	(2)
J. Y. Uriu-Adams
B. J. Horwath
F. J. Murray
G. Downing
P. Strong
C. L. Keen
Boron Stimulates Yeast Growth	1087	(1)
A. Bennett
N. Soch
R. Rowe
C. D. Eckhert
Does Boron Act on Transcription and Translation of Proteins?	1088	(3)
M. Dzondo-Gadet
R. Mayap Nzietchueng
K. Hess
P. Nabet
F. Belleville
B. Dousset
VI. TRACE ELEMENT ANALYSIS
New Sensitive Methods in the Determination of Trace Elements	1091	(8)
P. Schramel
Distribution of Selenium, Arsenic, Iron, and Scandium in Selenium-Deficient Rats Using the Multitracer Technique	1099	(4)
Rieko Hirunuma
Shuichi Enomoto
Shizuko Ambe
Fumitoshi Ambe
Separation of Metallothionein Isoforms and Identification of Complexed Metals by Capillary Zone Electrophoresis Using Diode Array Detection	1103	(4)
V. Virtanen
G. Bordin
A.-R. Rodriguez
Inductively Coupled Plasma Time of Flight Mass Spectrometry for Trace Element---and Speciation Analysis	1107	(4)
Hakan Emteborg
Xiaodan Tian
Monika Heisterkamp
Freddy C. Adams
Silicon Absorption from Stabilized Orthosilicic Acid and Other Supplements in Healthy Subjects	1111	(4)
M. Calomme
P. Cos
P. D'Haese
R. Vingerhoets
L. Lamberts
M. De Broe
C. Van Hoorebeke
D. Vanden Berghe
Preparation and ICP-MS Measurements of Magnesium Stable Isotopes in Human Samples	1115	(1)
M. Sabatier
W. R. Keyes
M. J. Arnaud
J. R. Turnlund
Characterization of Zinc Metallothioneins Using Electroanalytical Methods	1116	(1)
M. Dabrio
A. R. Rodriguez
Hepatic Metallothionein Isoforms Induction by Cadmium and Its Detection Using Capillary Electrophoresis	1117	(2)
B. Ribas Ozonas
O. Garcia Arribas
M. Perez Calvo
Recent Developments in HPLC-ICP-MS for the ``Difficult'' Elements	1119	(1)
F. Abou-Shakra
P. Booker
Determination of Heavy Metals in Calcium and Herbal Supplements Utilizing Inductively Coupled Plasma Mass Spectrometry (ICP-MS)	1120	(1)
Elzbieta (Ela) Bakowska
Overview of Biomedical Applications of Inductively Coupled Plasma Mass Spectrometry (ICP-MS)	1121	(1)
Elzbieta (Ela) Bakowska
Determination of Serum Cobalt at the Nanomolar Level by Direct Electrothermal Atomic Absorption Spectrometry	1122	(3)
J. Poupon
V. Gleizes
G. Saillant
M. Galliot-Guilley
List of Participants	1125	(24)
Author Index	1149	(8)
Subject Index	1157