Transcription Factors Normal and Malignant Development of Blood Cells

by Ravid, Katya; Licht, Jonathan D.

• ISBN13: 9780471350545
• ISBN10: 0471350540
• Edition: 1st
• Format: Hardcover
• Copyright: 2000-12-29
• Publisher: Wiley-Liss

Summary

Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In additionto updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors im

Author Biography

Katya Ravid is the editor of Transcription Factors: Normal and Malignant Development of Blood Cells, published by Wiley. Jonathan D. Licht is the editor of Transcription Factors: Normal and Malignant Development of Blood Cells, published by Wiley.

Table of Contents

Introduction	ix
Katya Ravid
Jonathan D. Licht
Contributors	xiii
I. TRANSCRIPTION FACTORS AND THE MEGAKARYOCYTIC AND ERYTHROID LINEAGES	0	(85)
The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation	1	(12)
Alice P. Tsang
John D. Crispino
Stuart H. Orkin
Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2	13	(18)
Sang-We Kim
Ramesh A. Shivdasani
Transcription Factors Involved in Lineage-Specific Gene Expression During Megakaryopoiesis	31	(20)
Yulia Kaluzhny
Mortimer Poncz
Katya Ravid
Role of TAL1/SCL Transcription Factor in Normal and Leukemic Hematopoiesis	51	(20)
Stephen J. Brandt
EKLF and the Development of the Erythroid Lineage	71	(14)
James J. Bieker
II. TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE	85	(96)
RUNX1(AML1) and CBFB: Genes Required for the Development of All Definitive Hematopoietic Lineages	87	(16)
Nancy A. Speck
Elaine Dzierzak
PU.1 and the Development of the Myeloid Lineage	103	(14)
Daniel G. Tenen
CCAAT/Enhancer-Binding Proteins in Myeloid Cells	117	(16)
Dong-Er Zhang
Homeobox Gene Networks and the Regulation of Hematopoiesis	133	(16)
Guy Sauvageau
R. Keith Humphries
H. Jeffrey Lawrence
Corey Largman
The Role of Retinoic Acid Receptors in Myeloid Differentiation	149	(14)
Steven J. Collins
Barton S. Johnson
Louise E. Purton
Transcriptional Targets of the Vitamin D3 Receptor During Myeloid Cell Differentiation	163	(18)
V. Carrie Bromleigh
Jeremy Ward
Leonard P. Freedman
III. TRANSCRIPTION FACTORS AND THE LYMPHOID LINEAGE	181	(144)
The Role of Ikaros Family Genes in Lymphopcyte Differentiation and Proliferation	183	(18)
Nicole Avitahl
Susan Winandy
Katia Georgopoulos
The Role of PU.1 in B-Lymphocyte Development and Function	201	(16)
Sridhar Rao
M. Celeste Simon
The Role of Pax5 (BSAP) in Early and Late B-Cell Development	217	(12)
Markus Horcher
Dirk Eberhard
Meinrad Busslinger
Janus Kinases and STAT Family Transcription Factors: Their Role in the Function and Development of Lymphoid Cells	229	(26)
Tammy P. Cheng
Jerome Galon
Roberta Visconti
Massimo Gadina
John J. O'Shea
E2A and the Development of B and T Lymphocytes	255	(16)
Barbara L. Kee
Cornelis Murre
The Role of BCL-6 in Normal Lymphoid System and non-Hodgkin's Lymphomas	271	(20)
B. Hilda Ye
The Role of Octamer Factors and Their Coactivators in the Lymphoid System	291	(22)
Eric Bertolino
Ralph Tiedt
Patrick Matthias
Harinder Singh
The Role of Early B-Cell Factor in B-Lymphocyte Development	313	(12)
Mikael Sigvardsson
IV. TRANSCRIPTION FACTORS INVOLVED IN LEUKEMIAS DUE TO CHROMOSOMAL TRANSLOCATION	325	(194)
The Role of RARa and Its Fusion Partners in Acute Promyelocytic Leukemia	327	(52)
Ari Melnick
Jonathan D. Licht
The Leukemogenic Function of the inv(16) Fusion Gene CBFB-MYH11	379	(14)
P. Paul Liu
Lucio H. Castilla
Neeraj Adya
EVI1 Rearrangements in Malignant Hematopoiesis	393	(16)
Giuseppina Nucifora
t(8;21) AML and the AML1/ETO Fusion Gene: From Clinical Syndrome to Paradigm for the Molecular Basis of Acute Leukemia	409	(16)
Richard C. Frank
Stephen D. Nimer
TEL/ETV6 Gene Rearrangements in Human Leukemias	425	(22)
Ema Anastasiadou
Michael H. Tomasson
David W. Sternberg
Todd R. Golub
Gary Gilliland
MLL in Normal and Malignant Hematopoiesis	447	(18)
Paul M. Ayton
Michael L. Cleary
Coactivators and Leukemia: The Acetylation Connection with Translocations Involving CBP, p300, TIF2, MOZ, and MLL	465	(18)
Vandana Chinwalla
Nancy J. Zeleznik-Le
The LMO2 Master Gene; Its Role as a Transcription Regulator Determining Cell Fate in Leukemogenesis and in Hematopoiesis	483	(14)
Yoshihiro Yamada
Terence H. Rabbitts
The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations	497	(22)
Gerd A. Blobel
V. ONCOGENESIS AND HEMATOPOIESIS	519	(52)
The Roles of the c-myc and c-myb Oncogenes in Hematopoiesis and Leukemogenesis	521	(30)
Marcello Arsura
Gail E. Sonenshein
NF-kB in Cell Life and Death	551	(20)
Winnie E. Tam
Jyoti Sen
Ranjan Sen
VI. SUMMARY OF TRANSCRIPTION FACTORS IMPLICATED IN HEMATOPOIESIS: IN VIVO STUDIES	571	(28)
Transcription Factors Implicated in Hematopoiesis: In Vivo Studies	573	(20)
Yulia Kaluzhny
Katya Ravid
Chromosomal Translocations Associated with Disruption of Transcriptional Regulators in Leukemia and Lymphoma	593	(6)
Jonathan D. Licht
Index	599