Transfusion Microbiology

by Edited By John A. J. Barbara, Fiona A. M. Regan, Marcela Contreras

• ISBN13: 9780521453936
• ISBN10: 0521453933
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-07-07
• Publisher: Cambridge University Press

Summary

Extensive measures are taken to ensure that blood transfusion poses a minimal microbiological hazard to recipients. Transfusion Microbiology is the definitive text on all aspects of transfusion transmitted infections. This comprehensive text covers all medical, scientific, technical and developmental aspects of this critically important sector of transfusion medicine. A detailed discussion of all infective agents, donor issues, testing and pathogen inactivation is provided. Agents causing major concern recently, such as vCJD, are considered in the context of historical experience with agents such as HIV. All aspects of risk assessment, regulation, cost benefit analysis and quality management are reviewed. Relevant to blood transfusion centres, hospital transfusion laboratories, haematologists and microbiologists, medical, scientific and technical staff, universities and general training programmes worldwide, Transfusion Microbiology provides an up-to-date resource for all practitioners and researchers involved in transfusion medicine.

Table of Contents

Foreword

Preface

Acknowledgements

Glossary

Introduction

Agents

Hepatitis viruses

Anti-HBc

Herpes viruses Eleftherios

Retroviruses

Parvovirus B19 (human erythroviruses)

Emerging viruses in transfusion

Bacterial contamination in blood and blood components

Annexe

The protozoan parasites

Prion diseases

Annexe, Testing for prions

Selection and Testing

Blood donor selection and qualification

Current serological methods of testing and automation

Confirmatory testing and donor readmission

The strategy for applications of nucleic acid testing

Nucleic acid testing, general view

Nucleic acid testing, the US approach

Nucleic acid testing, the English approach

Quality in the screening of donations for transfusion transmissible infections

Microbiological blood testing and new technologies

Processing and components, Leucodepletion and pathogen reduction Rebecca Cardigan

Fractionated products

Surveillance, Risk and Regulation

Serious hazards of transfusion (SHOT), Haemovigilance

Investigation of post transfusion infection Patricia

Notification of donors with significant microbiological test results Patricia

Researching the natural history of transfusion transmitted infections, the UK hepatitis C national register

How to assess risk, prospective studies and calculations

Risk management

The regulatory environment in Europe

Blood safety in developing countries

Index

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