Transgenic Models in Pharmacology

by Offermanns, Stefan; Hein, Lutz; Bader, M.; Basile, A. S. (CON); Berger, S. (CON); Bernhardt, G. (CON); Biel, M. (CON)

• ISBN13: 9783540001096
• ISBN10: 3540001093
• Format: Hardcover
• Copyright: 2003-12-01
• Publisher: Springer Verlag

Summary

The aim of this volume is to give up-to-date information on animal models generated by transgenic or gene targeting techniques. Naturally, the focus is on the mouse system. Each chapter has been written by leading experts in the field and gives an overview on existing animal models. This is facilitated by tables, which list the most important genetically engineered animal models and their phenotypes. This book aims at illustrating the impact of transgenic animal models in the field of Experimental Pharmacology and Toxicology, which includes their role in the understanding of basic cellular mechanisms, the evaluation of potential drug targets or the testing for drug effects.

Table of Contents

Part 1. Transgenic Techniques
Inducible Transgene Systems	3	(30)
S. Berger
H. Bujard
Part 2. Molecular Systems
Adrenergic System	33	(32)
S. Engelhardt
L. Hein
Muscarinic Acetylcholine Receptor Knockout Mice	65	(30)
J. Wess
W. Zhang
A. Duttaroy
J. Gomeza
Y. Cui
C. Deng
A. S. Basile
M. Yamada
F. P. Bymaster
D. L. McKinzie
C. C. Felder
T. Miyakawa
Mouse Models of NO/ Natriuretic Peptide/ cGMP Kinase Signaling	95	(36)
F. Hofmann
M. Biel
R. Feil
T. Kleppisch
Transgenic Models for the Study of Protein Kinase A-regulated Signal Transduction	131	(34)
C. M. Niswender
G. S. McKnight
G-Protein-Mediated Signalling Pathways	165	(28)
S. Offermanns
Analysis of Integrin Function by Gene Targeting in Mice	193	(36)
O. Brandau
R. Fassler
Part 3. Nervous System
Transgenic Mouse Models in the Analysis of Neurotransmitter Release Mechanisms	229	(32)
N. Brose
J. Rettig
Analysis of GABA Receptor Assembly and Function in targeted mutant mice	261	(24)
U. Rudolph
Neurotrophic Factors	285	(26)
M. Sendtner
Genetic Analysis of the Endogenous Opioid System	311	(34)
J. E. Pintar
B. L. Kieffer
Part 4. Cardiovascular System
Transgenic Mouse Models of Cardiovascular Function and Disease	345	(24)
B. C. Blaxall
W. J. Koch
Renin-Angiontensin-System/Blood Pressure Control	369	(28)
M. Bader
Lipoprotein Transport	397	(28)
H. H. Bock
P. May
J. Herz
Part 5. Immunology/Hematology/Inflammation
Transgenic Animals of Enzymes and Receptors in Prostanoid Synthesis and Actions; Phenotypes and Implications in Drug Development	425	(44)
S. Narumiya
Coagulation and Fibrinolysis in Genetically Modified Mice	469	(40)
B. Isermann
H. Weiler
Transgenic Animals in Primary Hemostasis and Thrombosis	509	(36)
C. Gachet
B. Hechler
C. Leon
J.-P. Cazenave
F. Lanza
Chemokine Receptors	545	(30)
G. Bernhardt
O. Pabst
H. Herbrand
R. Forster
Part 6. Endocrinology
Steroid Receptors	575	(32)
E.F. Greiner
T. Wintermantel
G. Schutz
Reproductive System	607	(32)
M. Poutanen
F.-P. Zhang
S. Rulli
S. Makela
P. Sipila
J. Toppari
I. T. Huhtaniemi
Part 7. Toxicology
Understanding Molecular Mechanism of Toxicity and Carcinogenicity Using Gene Knockout and Transgenic Mouse Models	639	(22)
G. Elizondo
F. J. Gonzalez
Subject Index	661