Transition Metal-Catalyzed Carbene Transformations

by Wang, Jianbo; Che, Chi-Ming; Doyle, Michael P.

• ISBN13: 9783527347995
• ISBN10: 3527347992
• Edition: 1st
• Format: Hardcover
• Copyright: 2022-05-16
• Publisher: Wiley-VCH

Summary

Presents an up-to-date overview of the rapidly growing field of carbene transformations

Carbene transformations have had an enormous impact on catalysis and organometallic chemistry. With the growth of transition metal-catalyzed carbene transformations in recent decades, carbene transformations are today an important compound class in organic synthesis as well as in the pharmaceutical and agrochemical industries. Edited by leading experts in the field, Transition Metal-Catalyzed Carbene Transformations is a thorough summary of the most recent advances in the rapidly expanding research area.

This authoritative volume covers different reaction types such as ring forming reactions and rearrangement reactions, details their conditions and properties, and provides readers with accurate information on a wide range of carbene reactions. Twelve in-depth chapters address topics including carbene C-H bond insertion in alkane functionalization, the application of engineered enzymes in asymmetric carbene transfer, progress in transition-metal-catalyzed cross-coupling using carbene precursors, and more. Throughout the text, the authors highlight novel catalytic systems, transformations, and applications of transition-metal-catalyzed carbene transfer.

• Highlights the dynamic nature of the field of transition-metal-catalyzed carbene transformations
• Summarizes the catalytic radical approach for selective carbene cyclopropanation, high enantioselectivity in X-H insertions, and bio-inspired carbene transformations
• Introduces chiral N,N'-dioxide and chiral guanidine-based catalysts and different transformations with gold catalysis
• Discusses approaches in cycloaddition reactions with metal carbenes and polymerization with carbene transformations
• Outlines multicomponent reactions through gem-difunctionalization and transition-metal-catalyzed cross-coupling using carbene precursors

Transition Metal-Catalyzed Carbene Transformations is essential reading for all chemists involved in organometallics, including organic and inorganic chemists, catalytic chemists, and chemists working in industry.

Author Biography

Jianbo Wang is full professor at Peking University. He received his Ph.D. from Hokkaido University (under the supervision of Prof. Hiroshi Suginome) in 1990. He was postdoctoral associate at the University of Geneva from 1990 to 1993 with Prof. Charles W. Jefford, and at the University of Wisconsin-Madison from 1993 to 1995 with Prof. Howard E. Zimmerman.
Prof. Wang's research interests is focused on catalytic metal carbene transformations. He has published over 300 articles in peer-reviewed journals, including >50 papers published in Nat. Chem., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Rev., and Acc. Chem. Res. These papers have been cited >11000 times. He serves as associate editor of the Journal of Physical Organic Chemistry (Wiley) and Chinese Journal of Organic Chemistry. He is on the editorial advisory board of Organic Letters and Tetrahedron/Tetrahedron Letters.

Table of Contents

INTRODUCTION

DEVELOPMENTS OF NEW CATALYSTS FOR METAL CARBENE TRANSFORMATIONS

CYCLOPROPANATIONS, CYCLOPROPENATIONS, AND RELATED REACTIONS

C-H INSERTION REACTIONS WITH CARBENE

HETEROATOM-HYDROGEN INSERTIONS WITH CARBENE

YLIDE FORMATION AND RELATED REACTIONS

CARBENE DIMERIZATION FOR OLEFIN SYNTHESIS

TRANSITION-METAL-CATALYZED CROSS-COUPLING WITH CARBENE

TRANSITION-METAL-CATALYZED TRANSFORMATION WITH VINYL DIAZOACETATES

TRANSITION-METAL-CATALYZED CARBENE TRANSFER IN POLYMERIZATION

APPLICATION OF TRANSITION-METAL-CATALYZED REACTIONS IN TOTAL SYNTHESIS

TRANSITION-METAL-CATALYZED CARBENE TRANSFER REACTION IN FLOW CHEMISTRY