Translational Control of Gene Expression

by Sonenberg, Nahum; Hershey, John W. B.; Mathews, Michael

• ISBN13: 9780879695682
• ISBN10: 0879695684
• Edition: 2nd
• Format: Hardcover
• Copyright: 2000-10-01
• Publisher: Cold Spring Harbor Laboratory Pr

Summary

McGill Univ., Montreal, Canada. Topics include: origins and principles of translational control, pathway and mechanism of initiation of protein synthesis, protein biosynthesis elongation cycle, interaction of mRNA translation and mRNA degradation in Saccharomyces cerecisiae, and more. For students and researchers.

Table of Contents

Preface	ix
Origins and Principles of Translational Control	1	(32)
M.B. Mathews
N. Sonenberg
J.W.B. Hershey
Pathway and Mechanism of Initiation of Protein Synthesis	33	(56)
Hershey
W.C. Merrick
The Protein Biosynthesis Elongation Cycle	89	(38)
W.C. Merrick
J. Nyborg
Comparative View of Initiation Site Selection Mechanisms	127	(58)
R.J. Jackson
Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes	185	(60)
A.G. Hinnebusch
Regulation of Ribosomal Recruitment in Eukaryotes	245	(50)
B. Raught
A.-C. Gingras
N. Sonenberg
Translational Control of Developmental Decisions	295	(76)
M. Wickens
E.B. Goodwin
J. Kimble
S. Strickland
M. Hentze
Viral Translational Strategies and Host Defense Mechanisms	371	(54)
T. Pe'ery
M.B. Mathews
Ribosomal Subunit Joining	425	(22)
T.V. Pestova
T.E. Dever
C.U.T. Hellen
Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A) Tail	447	(20)
A. Sachs
Translation Termination: It's Not the End of the Story	467	(20)
E.M. Welch
W. Wang
S.W. Peltz
Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae	487	(16)
T.F. Donahue
Double-stranded RNA-activated Protein Kinase PKR	503	(26)
R.J. Kaufman
Heme-regulated eIF2α Kinase	529	(18)
J.-J. Chen
PERK and Translational Control by Stress in the Endoplasmic Reticulum	547	(14)
D. Ron
H.P. Harding
Regulation of Translation Initiation in Mammalian Cells by Amino Acids	561	(20)
S.R. Kimball
L.S. Jefferson
Translational Control during Heat Shock	581	(14)
R.J. Schneider
Translational Control by Upstream Open Reading Frames	595	(20)
A.P. Geballe
M.S. Sachs
Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation	615	(22)
M.S. Carter
K.M. Kuhn
P. Sarnow
Translational Control and Cancer	637	(18)
J.W.B. Hershey
S. Miyamoto
Translational Control of Ferritin Synthesis	655	(16)
T.A. Rouault
J.B. Harford
Translational Control of TOP mRNAs	671	(24)
O. Meyuhas
E. Hornstein
S6 Phosphorylation and Signal Transduction	695	(24)
S. Fumagalli
G. Thomas
Control of the Elongation Phase of Protein Synthesis	719	(22)
C. Proud
Programmed Translational Frameshifting, Hopping, and Readthrough of Termination Codons	741	(22)
P.J. Farabaugh
Q. Qian
G. Stahl
Recoding UGA as Selenocysteine	763	(22)
M.J. Berry
Influence of Polyadenylation-induced Translation on Metazoan Development and Neuronal Synaptic Function	785	(22)
J.D. Richter
Interaction of mRNA Translation and mRNA Degradation in Saccharomyces cerevisiae	807	(20)
D.C. Schwartz
R. Parker
Destabilization of Nonsense-containing Transcripts in Saccharomyces cerevisiae	827	(22)
A. Jacobson
S.W. Peltz
Nonsense-mediated RNA Decay in Mammalian Cells: A Splicing-dependent Means to Down-regulate the Levels of mRNAs That Prematurely Terminate Translation	849	(20)
L.E. Maquat
Translation Initiation on Picornavirus RNA	869	(32)
G.J. Belsham
R.J. Jackson
Adenovirus Inhibition of Cellular Protein Synthesis and Preferential Translation of Viral mRNAs	901	(14)
R.J. Schneider
Reovirus Translational Control	915	(18)
A.J. Shatkin
Translational Reprogramming during Influenza Virus Infection	933	(18)
S.-L. Tan
M. Gale, Jr.
M.G. Katze
Translational Control in Poxvirus-infected Cells	951	(22)
B.L. Jacobs
Nontranslational Functions of Components of the Translational Apparatus	973	(26)
T.G. Kinzy
E. Goldman
Index	999