Transplant-Associated Coronary Artery Vasculopathy

by Kulkarni,Rohit N.

• ISBN13: 9781587060052
• ISBN10: 1587060051
• Format: Hardcover
• Copyright: 2014-09-16
• Publisher: CRC Press

Summary

Imperial College School of Medicine, Middlesex, UK. Reviews recent knowledge and findings in the field. Designed to aid in the management and further understanding of this disease. For researchers and clinicians. Hardcover. NOTE: Softcover is only available as a reprint when the hardcovers are depleted. DNLM: Heart Transplantation.

Table of Contents

Coronary Arterial Disease in the Cardiac Allograft	1	(26)
Nicholas R. Banner
Terminology	1	(1)
Characteristics of Transplant-Related Coronary Disease	2	(5)
Incidence and Prognosis	7	(2)
Methods of Detecting Transplant-related Coronary Disease for Clinical Diagnosis and Research	9	(7)
Therapeutic Approaches to Transplant-Related Coronary Disease	16	(2)
Conclusions	18	(8)
Atherosclerosis: Response to Injury	26	(45)
Nick Gall
Robin Poston
Introduction	26	(1)
General Pathology	26	(4)
Important Molecules in Atherogenesis	30	(11)
Mechanisms in Atherogenesis	41	(16)
Risk Factors for Atherosclerosis	57	(3)
The Positive Feedback Hypothesis	60	(11)
The Immune Response to Endothelial Cells	71	(19)
Marlene L. Rose
Basic Mechanism of Rejection	71	(6)
Endothelial Cells as Antigen Presenting Cells	77	(13)
Role of Hemostasis, Anticoagulation, Fibrinolysis and Endothelial Activation	90	(28)
Carlos A. Labarrere
David R. Nelson
Patients and Methods	91	(2)
Myocardial Fibrin and Transplant-Associated CAD	93	(5)
Vascular Antithrombin and Transplant-Associated CAD	98	(4)
Arterial and Arteriolar Endothelial Activation and Transplant-Associated CAD	102	(4)
Arteriolar Tissue Plasminogen Activator and Transplant-Associated CAD	106	(2)
Relationship of all Immuno-histochemical Measures with Transplant-Associated CAD	108	(4)
Conclusions and Future Directions	112	(6)
Nonimmune Factors in the Etiology of Graft Coronary Arteriosclerosis	118	(11)
Hiroaki Nagano
Nicholas L. Tilney
The Cadaver Donor and Early Organ Injury	119	(2)
Late Influences on Graft Arteriosclerosis	121	(2)
The Common Pathway	123	(2)
Conclusions	125	(4)
Tissue Remodeling and Extracellular Matrix Proteins	129	(12)
Marlene Rabinovitch
Fibronectin and Smooth Muscle Cell Migration	129	(9)
Conclusions	138	(2)
Abbreviations	140	(1)
Insights Regarding the Pathogenesis of Transplant Arteriopathy from Experiments with Animals	141	(25)
Paul S. Russell
Catharine M. Chase
Robert B. Colvin
Experimental Systems	142	(3)
Quantification of Vascular Changes	145	(1)
Some Findings from Animal Experiments	146	(8)
Involvement of Cytokines, Adhesion Molecules and Growth Factors	154	(4)
Pathogenesis of Transplant Arteriopathy	158	(1)
Some Approaches to the Control of Transplant Vasculopathy	159	(2)
Summary	161	(5)
Cytomegalovirus as a Contributing Factor in Transplant Vascular Sclerosis	166	(15)
W. James Waldman
Deborah A. Knight
Adriana Zeevi
Overview	166	(1)
Biology of Human Cytomegalovirus	166	(2)
CMV as a Contributing Factor in TVS: Clinical Observations and Animal Studies	168	(3)
Graft Endothelial Activation and Host Inflammatory Responses	171	(1)
CMV as a Catalyst of TVS Development: Potential Mechanisms	172	(3)
Epilogue	175	(6)
Lipids and Lipid Lowering Therapy	181	(9)
Jon A. Kobashigawa
Potential Causes of Hyperlipidemia	181	(1)
Clinical Course	182	(1)
Treatment of Hyperlipidemia	183	(3)
Summary	186	(4)
Immunosuppressive Drugs for the Prevention and Treatment of Transplant Coronary Artery Vasculopathy	190	(19)
Norman P. Briffa
C.R. Gregory
Randall E. Morris
Biology	190	(1)
Studies of Chronic Rejection	191	(1)
Mechanisms	191	(3)
Azathioprine	194	(1)
Cyclosporine	194	(1)
In Vitro Studies	194	(1)
Preclinical Studies	195	(1)
Tacrolimus	196	(2)
Mycophenolate Mofetil	198	(1)
Pharmacokinetics and Mechanism of Action	198	(1)
Sirolimus (Rapamycin)	199	(2)
Leflunomide/Malononitrilamides	201	(1)
Future	201	(1)
Conclusion	202	(7)
Index	209