9781936113880

Transplantation

by ;
  • ISBN13:

    9781936113880

  • ISBN10:

    1936113880

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2013-12-31
  • Publisher: Cold Spring Harbor Laboratory Press

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Supplemental Materials

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  • The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.
  • The Rental copy of this book is not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

Summary

The transplantation of organs such as the heart, kidney, and lungs is an important means of replacing seriously damaged or diseased body parts. However, a transplanted organ may fail if the recipient's immune system mounts a response to it. Transplant patients are usually prescribed a life-long course of immunosuppressive medication, but these drugs can have adverse effects, including increased risk of infection and cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a current and comprehensive review of the molecular mechanisms behind graft rejection and how they may be overcome. Contributors discuss immunosuppressive drug therapies and tolerance induction strategies, including the use of regulatory T cells, mesenchymal stromal cells, and lymphodepletion. They describe how mouse and non-human primate models have been used to gain insight into the immunobiology of transplantation and to test therapeutic approaches. Clinical considerations, such as donor selection, organ preservation, surgery, and post-operative care, are also covered.

This volume provides historical background to the field and includes discussion of the emerging field of regenerative medicine and the bioethical issues surrounding organ transplantation. It is an essential reference for immunologists, pharmacologists, clinicians, and all who are working to improve this remarkable medical procedure.

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