Summary

Organ transplantation is now an established treatment for patients with organ failure. Transplantation is taught on all medical student curricula and is part of specialty training in medicine and surgery. In addition nursing staff spend time on transplant wards during their training and pharmacists both in hospital and outside deal with transplant patients and immunosuppressants regularly. Transplantation at a Glance provides a succinct overview of both the scientific and clinical principles of organ transplantation which will appeal to this wide-ranging market.

Author Biography

Menna Clatworthy is at the University of Cambridge and Addenbrooke's Hospital

Christopher Watson is at the School of Clinical Medicine, University of Cambridge

Michael Allison is at Cambridge University Hospitals NHS Foundation Trust

John Dark is Professor of Cardiothoracic Surgery at the Regional Cardiothoracic Centre, The Freeman Hospital, Newcastle upon Tyne

Preface 7

List of abbreviations 8

1 History of transplantation 10

Organ donors

2 Diagnosis of death and its physiology 12

3 Deceased organ donation 14

4 Live donor kidney transplantation 16

5 Live donor liver transplantation 18

Organ preservation

6 Organ preservation 20

Immunology of organ transplantation

7 Innate immunity 22

8 Adaptive immunity and antigen presentation 24

9 Humoral and cellular immunity 26

Histocompatibility in transplantation

10 Tissue typing and HLA matching 28

11 Detecting HLA antibodies 30

12 Antibody-incompatible transplantation 32

Organ allocation

13 Organ allocation 34

Immunosuppression

14 Immunosuppression: induction vs maintenance 36

15 Biological agents 37

16 T cell-targeted immunosuppression 38

Complications of immunosuppression

17 Side effects of immunosuppressive agents 40

18 Post-transplant infection 42

19 CMV infection 44

20 Post-transplant malignancy 46

Kidney transplantation

21 End-stage renal failure 48

22 Complications of ESRF 50

23 Dialysis and its complications 52

24 Assessment for kidney transplantion 54

25 Kidney transplantation: the operation 56

26 Surgical complications of kidney transplantation 58

27 Delayed graft function 60

28 Transplant rejection 62

29 Chronic renal allograft dysfunction 64

Pancreas and islet transplantation

30 Transplantation for diabetes mellitus 66

31 Pancreas transplantation 68

32 Islet transplantation 70

Liver transplantation

33 Causes of liver failure 72

34 Assessment for liver transplantation 74

35 Liver transplantation: the operation 76

36 Complications of liver transplantation 78

Intestinal transplantation

37 Intestinal failure and assessment 80

38 Intestinal transplantation 82

Heart transplantation

39 Assessment for heart transplantation 84

40 Heart transplantation: the operation 86

41 Complications of heart transplantation 88

Lung transplantation

42 Assessment for lung transplantation 90

43 Lung transplantation: the operation 92

44 Complications of lung transplantation 94

Composite tissue transplantation

45 Composite tissue transplantation 96

Xenotransplantation

46 Xenotransplantation 98

Index 100

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