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Summary

Treatment resistant schizophrenia (TRS) is common, affecting approximately a third of patients diagnosed. Despite the prevalence of TRS, the best approach to practical management is often unclear to clinicians and patients.

Treatment Response and Resistance in Schizophrenia offers a practical, clinically focused guide to TRS and the real-world challenges faced by those impacted. Over 14 chapters this resource covers the principles and practice of TRS, from the definition, epidemiology, and clinical assessment, to the pharmacological, physical, and psychological management of treatment resistance.

All chapters have been written by internationally leading experts in the field to ensure busy clinicians have high-quality, applicable content that is rooted in real clinical experiences. A chapter of case studies is included to link real-life scenarios to each of the instructive chapters, illustrating approaches to practical management and application.

Part of the Oxford Psychiatry Library, this useful pocket book is an invaluable resource and quick reference for psychiatrists, psychiatry trainees, and other mental health practitioners, as well as clinical psychologists, primary care physicians, and specialist nurses.

Author Biography

Oliver Howes, King's College London, London, Professor of Molecular Psychiatry

1. Introduction, Oliver Howes
2. Treatment response and resistance in schizophrenia: principles and definition, Robert McCutcheon, Christoph Correll, Oliver Howes, and John Kane
3. Maximizing response to first-line antipsychotics in Schizophrenia, Robert C. Smith, Stefan Leucht, and John M. Davis
4. Epidemiology, impact and predictors of treatment resistant schizophrenia, John Lally and James H. MacCabe
5. The neurobiology of antipsychotic treatment response and resistance, Stephen J. Kaar, Steven Potkin, and Oliver Howes
6. Pharmacological management of TRS: Fundamentals of clozapine, Yvonne S. Yang, and Stephen R. Marder
7. Managing common adverse-effect of clozapine, Christopher Rohde and Jimmi Nielsen
8. Pharmacological management of treatment-resistant schizophrenia: advanced use of clozapine, Siobhan Gee and David Taylor
9. Pharmacological management of TRS: alternatives to clozapine, Thomas R. E. Barnes
10. Psychosis and the family: the role of family interventions, Juliana Onwumere and Elizabeth Kuipers
11. Cognitive behavioral therapy for psychosis, Majella Byrne, Suzanne Jolley & Emmanuelle Peters
12. Ultra treatment resistance, Gary Remington, Ofer Agid, Hiroyoshi Takeuchi, Jimmy Lee, Araba Chintoh
13. Illustrative case studies, Ofer Agid, Thomas Barnes, Majella Byrne, Araba Chintoh, Christoph Correll, Siobhan Gee, Oliver Howes, Suzanne Jolley, John Lally, Jimmy Lee, John Kane, James MacCabe, Stephen R. Marder, Robert McCutcheon, Jimmi Nielsen, Emmanuelle Peters, Gary Remington, Christopher Rohde, Hiroyoshi Takeuchi, David Taylor, and Yvonne S. Yang
14. Novel treatments and future directions, Seiya Miyamoto and Nobumi Miyake

Supplemental Materials

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