Treatment-resistant Mood Disorders

by Edited by Jay D. Amsterdam , Mady Hornig , Andrew A. Nierenberg

• ISBN13: 9780521041812
• ISBN10: 0521041813
• Edition: 1st
• Format: Paperback
• Copyright: 2007-10-08
• Publisher: Cambridge University Press

Summary

While antidepressants have helped millions worldwide, a substantial proportion of patients fail to respond or remit. There is little published information available to clinicians for diagnosis and management of treatment-resistant depression, so they have had to make difficult decisions about treatment options with very limited data. The editors and their internationally distinguished team of contributors have set out to address this problem, giving a critical assessment of all aspects of treatment-resistant depression: causes, epidemiology, comorbidity, evaluation and treatment. This timely book will be invaluable to clinicians, neuroscientists, researchers and graduate students.

Table of Contents

List of contributors

Preface

The Clinical Problem

The characterization and definition of treatment-resistant mood disorders Daniel Souery, Olivier Lipp, Isabelle Massat and Julien Mendlewicz

Overview of treatment-resistant depression and its management John P. O'Reardon and Jay D. Amsterdam

Biological Basis

Psychoneuroendocrine aspects of treatment-resistant mood disorders Owen

Estrogen and depressive illness in women

Sleep abnormalities in treatment-resistant mood disorders

Structural and functional brain imaging in treatment-resistant depression Terence

Immunologic factors in treatment-resistant depression

Treatment Approaches

Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in treatment-resistant depression

Conventional and second generation monoamine oxidase inhibitors in treatment-resistant depression

Drug combination strategies Lawrence

Electroconvulsive therapy in medication-resistant depression Max Fink

Thyroid augmentation

Cognitive therapy and psychosocial interventions in chronic and treatment-resistant mood disorders

Special Patient Populations

Chronic and refractory mood disorders in childhood and adolescence Adelita Segovia

Treatment-resistant depression in the elderly Paul A. Newhouse

Management of treatment-resistant depression during pregnancy and the postpartum period

Preliminary algorithms for treatment-resistant bipolar depression

Medical disorders and treatment-resistant depression

Psychiatric comorbidity in treatment-resistant depression

Suicide in treatment-refractory depression

Economic and Ethical Issues

The economic impact of treatment non-response in major depressive disorders

Ethical issues in research and treatment of patients with mood disorders

Index

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