Treatment-Resistant Mood Disorders

by Edited by Jay D. Amsterdam , Mady Hornig , Andrew A. Nierenberg

• ISBN13: 9780521593410
• ISBN10: 0521593417
• Format: Hardcover
• Copyright: 2001-07-16
• Publisher: Cambridge University Press

Summary

While antidepressants have helped millions worldwide, a substantial proportion of patients fail to respond or remit. There is little published information available to clinicians for diagnosis and management of treatment-resistant depression, so they have had to make difficult decisions about treatment options with very limited data. The editors and their internationally distinguished team of contributors have set out to address this problem, giving a critical assessment of all aspects of treatment-resistant depression: causes, epidemiology, comorbidity, evaluation and treatment. This timely book will be invaluable to clinicians, neuroscientists, researchers and graduate students.

Table of Contents

List of contributors	x
Preface	xv
Part I The clinical problem	1	(46)
The characterization and definition of treatment-resistant mood disorders	3	(27)
Daniel Souery
Olivier Lipp
Isabelle Massat
Julien Mendlewicz
Overview of treatment-resistant depression and its management	30	(17)
John P. O'Reardon
Jay D. Amsterdam
Part II Biological Basis	47	(110)
Psychoneuroendocrine aspects of treatment-resistant mood disorders	49	(31)
Owen M. Wolkowitz
Victor I. Reus
Estrogen and depressive illness in women	80	(16)
Barbara B. Sherwin
Sleep abnormalities in treatment-resistant mood disorders	96	(15)
Martin P. Szuba
Antonio T. Fernando
Geralyn Groh-Szuba
Structural and functional brain imaging in treatment-resistant depression	111	(31)
Terence A. Ketter
Christopher J. Bench
Mark S. George
Tim A. Kimbrell
Robert M. Post
Immunologic factors in treatment-resistant depression	142	(15)
Anna Sluzewska
Janusz Rybakowski
Mady Hornig
Jay D. Amsterdam
Part III Treatment approaches	157	(114)
Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in treatment-resistant depression	159	(21)
William Boyer
Richard Bunt
Conventional and second generation monoamine oxidase inhibitors in treatment-resistant depression	180	(14)
David Bakish
Cynthia L. Hooper
Drug combination strategies	194	(29)
Lawrence H. Price
Linda L. Carpenter
Steven A. Rasmussen
Electroconvulsive therapy in medication-resistant depression	223	(16)
Max Fink
Thyroid augmentation	239	(13)
Russell T. Joffe
Cognitive therapy and psychosocial interventions in chronic and treatment-resistant mood disorders	252	(19)
Jan Scott
Robert J. DeRubeis
Part IV Special patient populations	271	(218)
Chronic and refractory mood disorders in childhood and adolescence	273	(15)
Adelita Segovia
Kelly N. Botteron
Barbara Geller
Treatment-resistant depression in the elderly	288	(33)
Paul A. Newhouse
Jaskaran Singh
Management of treatment-resistant depression during pregnancy and the postpartum period	321	(29)
Zachary N. Stowe
Pamela McCreary
Amy Hostetter
Claudia Baugh
Alexis Llewellyn
Preliminary algorithms for treatment-resistant bipolar depression	350	(55)
Robert M. Post
Mark A. Frye
Kirk D. Denicoff
Andrew M. Speer
Susan R.B. Weiss
Gabriele S. Leverich
Medical disorders and treatment-resistant depression	405	(25)
John P. O'Reardon
Jay D. Amsterdam
Psychiatric comorbidity in treatment-resistant depression	430	(49)
Jonathan E. Alpert
Isabelle T. Lagomasino
Suicide in treatment-refractory depression	479	(10)
Jan Fawcett
Stanley G. Harris, Sr.
Part V Economic and ethical issues	489	(28)
The economic impact of treatment non-response in major depressive disorders	491	(13)
Jeffrey S. McCombs
Glen L. Stimmel
Rita L. Hui
T. Jeffrey White
Ethical issues in research and treatment of patients with mood disorders	504	(13)
Paul Root Wolpe
Arthur Caplan
Index	517