Tumor-Induced Immune Suppression

by Gabrilovich, Dmitry I.; Hurwitz, Arthur A.

• ISBN13: 9780387691176
• ISBN10: 0387691170
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-12-12
• Publisher: Springer Verlag

Summary

There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in more or less cohesive structure and how they can help to improve immune response to tumors. This monograph will, for the first time, present a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It will discuss a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance.

Table of Contents

Immune-Suppressive Mechanisms and Cancer: Understanding the Implications, Paradoxes, and Burning Questions	p. 1
Mechanisms of Tumor-Associated T-Cell Tolerance	p. 7
Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer	p. 29
Regulatory T Cells in Cancer	p. 41
Cancer-Induced Signaling Defects in Antitumor T Cells	p. 69
Immunobiology of Dendritic Cells in Cancer	p. 101
Macrophages and Tumor Development	p. 131
Myeloid-Derived Suppressor Cells in Cancer	p. 157
Signaling Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance	p. 197
Arginine Availability Regulates T-Cell Function in Cancer	p. 219
Protein-Glycan Interactions in the Regulation of Immune Cell Function in Cancer: Lessons from the Study of Galectins-1 and -3	p. 235
Role of Reactive Oxygen Species in T-Cell Defects in Cancer	p. 259
Tumor Stroma and the Antitumor Immune Response	p. 281
Subject Index	p. 295
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